Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Being pleomorphic, its histologic characteristics can be considerably varied, showing epithelial (ductal and non-ductal) cells and mesenchyme-like tissues (chondroid, myxoid, and osseous). Here, we present a rare case of a 76-year-old female presenting with a 2.0 cm PA with an epidermoid cyst of minor salivary glands on the soft palate.

Extramedullary plasmacytomas (EMPs) are rare soft tissue malignant neoplasms composed of plasma cells. They are sometimes found in soft tissues. The majority of primary EMPs occur in the head and neck region, especially in the upper respiratory tract and oral cavity. We present a case of a 52-year-old female with an EMP. The patient’s initial chief complaint was swelling of the soft palate. An excisional biopsy was performed under general anesthesia. Final pathologic diagnosis was EMP of the soft palate with partial involvement of the resection margin. In order to exclude the possibility of multiple myeloma, a bone marrow exam with chromosomal study was completed. The patient was also referred to the Department of Radiation Oncology for postoperative radiation therapy (PORT); however, the patient refused to undergo PORT. The patient is currently under close observation for signs and symptoms of recurrence or metastases through regular follow-up visits and imaging studies.

Clear cell adenocarcinoma (CCA) is a rare malignant neoplasm of salivary gland that represents only 1% of all salivary gland tumors. CCA is histopathologically characterized by monotonous, glycogen-rich, round to ovoid clear cells intermixed with hyalinized stroma. However, other salivary gland tumors such as mucoepidermoid carcinoma, acinic cell adenocarcinoma, oncocytoma, epithelial-myoepithelial carcinoma, and myoepithelial carcinoma should be ruled out to diagnosis CCA. We herein report a case of CCA involving the soft palate in a 56-year-old female. It is essential to consider CCA in the differential diagnoses of clear cell tumors.