Alzheimer's disease (AD) is one of the most common forms of dementia, affecting more than 50 million people globally. The onset of AD is linked to age, smoking, obesity, hypercholesterolemia, physical inactivity, depression, gender, and genetics of an individual. The accumulation of Aβ peptides and neurofibrillary tangles (NFTs) in the brain is one of the critical factors that lead to AD, which is known to disrupt neuronal signaling and causing neurodegeneration. As per the current understanding, inhibiting the accumulation of Aβ peptides and NFTs is crucial in the management/treatment of AD. Latest research studies show that nanoparticles have the potency of improving drug transport across the blood–brain barrier easily. Specifically, graphene quantum dots (GQDs), a type of semiconducting nanoparticles, have been established as effective inhibitors for blocking the aggregation of Aβ peptides. The small size of GQDs allows them to pass through the blood– brain barrier with ease. Moreover, GQDs have fluorescence properties, which can be used to detect the concentration of Aβ in vivo. In recent years, compared to other carbon materials, the low cytotoxicity and high biocompatibility of GQDs, give them an advantage in the suitability and clinical research for AD. In this manuscript, we have discussed the role of different types of nanoparticles in the transportation of encapsulated or co-assembled compound drugs for the treatment of AD and importantly, the role of GQDs in the diagnosis and management/treatment of AD.

The current study was conducted to facilitate appropriate hygiene and safety management in children’s food service stations, with the ultimate objective of providing sanitary and safe food service to children. In order to develop questionnaire items, literature review was conducted, in addition to detailed interview of working-level personnel at a children’s food service management support center. This resulted in a total of thirty questions on personal hygiene management, food materials hygiene management, and facilities hygiene management. Using the questionnaire, seventy-one food service stations for children in District A in Seoul that serve less than one hundred children were surveyed to analyze the reliability, construct validity, and correlation in the developed measurement tool. The developed measurement tool consisted of ten task and environmental hygiene management questions, five personal and cooking hygiene management questions, four food ingredient and storage hygiene management questions, and four food service operation and management question; with a total of twenty-three questions, in four factors stated above. The cumulative distribution of the four factors was 54.698%, and Cronbach’s α value was 0.672~0.853, which indicated that the study was reliable. The results of the analysis indicated that each of the factors were correlated, the study was satisfactory, and the tool was valid for evaluating hygiene and safety management practices in children’s food service stations. Finally, in order to enhance practical utility of the developed measurement tool, the significance and limitations were described.

With the introduction and implementation of the National Research and Development Innovation Act in 2021, researchers are required to have a greater understanding of research ethics and to comply more strictly. The range of misconduct in research and the standards for sanctions have been expanded with the introduction of the National Research and Development Innovation Act. In addition, researchperforming institutions and specialized agencies have been obligated to establish their own research management systems and standards according to the changed criteria. The Korea Institute of Nuclear Nonproliferation and Control (KINAC), a nuclear regulatory authority that is conducting national R&D in related fields, has sought to strengthen research ethics by revising related regulations, introducing a plagiarism detection system, and expanding related education in accordance with these policies. In this study, we analyzed the effectiveness of the plagiarism detection system as a basic quality control measure for research results and a tool for enhancing research ethics, which was introduced. KINAC did not simply introduce a plagiarism detection program but established institutional improvements and other regulatory measures to support it, with the aim of more effectively managing research results. To analyze the effectiveness of this system, we calculated the plagiarism rate by sampling 30 papers each year for the three years before the introduction of the plagiarism detection system. When comparing the plagiarism rates before and after the introduction of the plagiarism detection system, no exceptional cases of high plagiarism rates were found in papers published after the introduction of the system. Although most of the papers before the introduction of the system showed a satisfactory plagiarism rate, some cases showed high plagiarism rates. We analyzed the cause of such cases in detail. Some exceptional cases were also found to be included in the range of misconduct regulated by the National Research and Development Innovation Act. As no such cases were found after the introduction of the system, we could infer that the system is effectively functioning as a tool for basic quality control and enhancing research ethics. In the future, we plan to expand the sample qualitatively and quantitatively by including other forms of outcomes published by the institution, not just papers, and conduct a more detailed analysis. Based on the results, we will develop various improvement plans for enhancing the quality and research ethics of the institution’s research results.

A portable device which calculate and analysis the SOC structure data. This device can be used to estimate the building prior to install the sensing system. This sensing tools can help the system engineers to analyze the large SOC structure’s responses.

In this study is to develop hydrological and geotechnical analysis module and risk analysis and assessment tool for the development of the dam safety management decision-making support tool D-SMART. Analysis module is composed of two parts. One is the initial load probability result part to the hydrological and an earthquake characteristic, the other is system response probability result part.

The purpose of in this study to develop of the dam safety management assessment tool based risk assessment for the dam safety management paradigm shift. Therefore in this study is to develop hydrological and geotechnical analysis module and risk analysis and assessment tool for the development of the damsafety management decision-making support tool D-SMART.