With the fast pace of technological change, the role of innovation on a firm’s survival has received increased scholarly attention. This study investigates the relationship between a firm’s strategic orientations, exploration and exploitation, on innovation activity. Also, the synergy effects of four types of innovation: product, process, marketing, and organizational innovation are examined with the consideration of the level of innovativeness and the firm’s industrial category. The OECD Oslo Manual (2005) and the standard of OECD (2011) classification are used as a main source to define four different types of innovation and the industry category into high-tech and low-tech. This study uses data from 856 firms taken from the Korea Innovation Survey (KIS) 2014 which is the Korean version of the Community Innovation Survey (CIS). Since most of the measures are composed of multiple items, their reliability and the underlying dimensions of each measure are tested by principal component analysis (PCA). Structural equation modeling (SEM) is then used to carry out a simultaneous test the relationships among the constructs. The moderating effects of marketing and organizational innovation are examined through multi group analysis. Results indicate that exploration and exploitation have positive impacts on the product innovation and process innovation respectively. Also, a new process encourages firms to develop radical product innovation. In case of the moderating effect of marketing and organizatioanl innovation, there are some differences between high-tech and low-tech industry. For high-tech firms, the positive relationship between a new product and firm performance is increased with the introduction of marketing innovation. In case of low-tech firms, process innovation has direct and positive impacts on a firm’s performance with organizational innovation. The findings show that the synergy effect of innovation exists and its significance could be changed depending on an industrial category.

Bacillus thuringiensis subsp. kurstaki KB100 isolated from the domestic soil have the most effective activity against the beet armyworm, Spodoptera exigua larva. The tannic acid as protease inhibitor might be increased the efficacy of sublethal concentrations of B. thuringiensis. The tannic acid was identified as a protease inhibitor that could increased the efficacy of sublethal concentrations of B. thuringiensis. Mixture of B. thuringiensis and tannic acid was investigated the mortality of S. exigua larva in the laboratory and field. When B. thuringiensis treated to 2nd larva of S. exigua, mortality was shown 54.4%. However, mixtures of B. thuringiensis with 4 and 40 mM tannic acid were increased mortalities to 2nd larva of S. exigua as 64.0 and 95.5%, respectively. Also, synergy effect of mixture of B. thuringiensis and 40 mM tannic acid was increased the mortality of S. exigua 3rd larva to 93.3%, even though 60.0% mortality with only B. thuringiensis treatment. On the other hand, the mortality of mixture with B. thuringiensis and 80 mM tannic acid was 53.3% lower than B. thuringiensis single treatment. In the welsh onion field, the accumulated mortalities of 3 times replicated with mixture of B. thuringiensis and 40 mM tannic acid were 83.9, 89.4 and 66.8% compare with 61.8, 80.4 and 47.3% as only B. thuringiensis treatment, respectively.

Background : Turmeric (Curcuma longa L.) and black pepper (Piper nigrum L.) have traditionally been used as Asian medicinal and culinary herb. Curcumin, a major compound of turmeric, has been known to have antitumor activity. However, curcumin is bioavailable because it is rapidly metabolized and released from the body. Therefore, the addition of adjuvants such as piperine, a potent inhibitor of drug metabolism, is one of the ways to increase the bioavailability of curcumin. Methods and Results : The yields of turmeric and black pepper ethanolic extracts (TM and BP) are 18.2 and 8.2% (w/w), respectively. The EC50 values of A549 and NCI-H292 cells exposed to TM were 77.8 ㎍/㎖ and 92.0 ㎍/㎖, respectively. No significant cytotoxicity was observed up to the 400 ㎍/㎖ in the A549 and NCI-H292 exposed to BP. Based on the central composite design, the co-treatment of TM and BP enhanced the cytotoxicity of A549 and NCI-H292 cells. The optimal combination concentration (optimal EC50 value) of TM and BP calculated by the response surface methodology assay were 48.5 and 241.7 ㎍/㎖. The conbination index assay confirmed that the cytotoxic effect at optimal combinatino concentration was due to the synergistic effect. Conclusion : We hypothesized that co-treatment of TM and BP enhanced cytotoxicity more than single treatment of TM against lung cancer cells, and cell death at this time may synergetic cytotoxicity effects associated with curcumin metabolism.