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동물모델에서 인삼(Panax ginseng)의 비떨림 열발생과 미토콘드리아 기능 강화효과: 체계적 문헌고찰과 메타분석 KCI 등재

Panax Ginseng: A Promising Ally in Enhancing Non-Shivering Thermogenesis and Mitochondrial Function in Animal Models (A Systematic Review and Meta-Analysis)

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  • URLhttps://db.koreascholar.com/Article/Detail/436494
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산업식품공학 (Food Engineering Progress)
한국산업식품공학회 (Korean Society for Food Engineering)
초록

Obesity is the cause of many diseases, and its severity continues to increase. Promoting non-shivering thermogenesis is attracting attention as a new treatment strategy for obesity. This study summarized the studies that evaluated the effect of Panax ginseng on promoting non-shivering thermogenesis in animal models. A total of 7 studies were included according to the selection criteria, of which five were judged to have a high risk of bias. Indicators of UCP1 mRNA, UCP1 protein, and PGC- 1a were used in the meta-analysis, and the certainty of evidence progressed for each indicator, with UCP1 protein showing the highest certainty of evidence. Meta-analysis was conducted on 5 works of literature with standard indicators. As a result of meta-analysis, UCP1 protein level and PGC-1a mRNA level were significantly increased statistically. In addition, the protein levels of PRDM16 and TFAM increased in several studies (not a meta-analysis). These findings suggest that Panax ginseng could be a potential therapeutic agent for obesity. However, further research is needed to understand its mechanisms and possible side effects fully. Thus, it is concluded that Panax ginseng in animal models can promote non-shivering thermogenesis and improve mitochondria function in animal models, opening up new avenues for research and potential clinical applications.

목차
서 론
재료 및 방법
    핵심질문 설정
    문헌검색 및 선택
    비뚤림 위험 평가(risk of bias)
    근거 수준 평가
    메타분석
결과 및 고찰
    문헌의 검색 및 선정 결과
    비뚤림 위험 평가
    근거 수준 평가
    메타분석
    UCP1
    PGC-1a
요 약
References
Author Information
저자
  • 오채현(한양대학교 식품영양학과) | Chaehyun Oh (Department of Food and Nutrition, Hanyang University)
  • 이보경(한양대학교 식품영양학과) | Bogyeong Lee (Department of Food and Nutrition, Hanyang University)
  • 강수민(한양대학교 식품영양학과) | Sumin Kang (Department of Food and Nutrition, Hanyang University)
  • 김하윤(한양대학교 식품영양학과) | Hayoon Kim (Department of Food and Nutrition, Hanyang University)
  • 이하늘(한양대학교 식품영양학과) | Haneul Lee (Department of Food and Nutrition, Hanyang University)
  • 강경옥(부경대학교 식품영양학과) | Gyoungok Gang (Department of Food Science and Nutrition, Pukyong National University)
  • 이상길(부경대학교 식품영양학과) | Sang Gil Lee (Department of Food Science and Nutrition, Pukyong National University) Corresponding author
  • 고광웅(한양대학교 식품영양학과) | Gwang-woong Go (Department of Food and Nutrition, Hanyang University) Corresponding author