이상의 결과를 종합하면, 혼합유산균 2종(Bifidobacterium animalis ssp. Lactis Bf141와 Lactobacillus rhamnosus Lb102)의 섭취는 고지방식이 유도 비만 마우스에서 체중, 체지방, 제지방, 골밀도 등 주요 체성분에 영향을 주지 않았다. 혼합유산균은 식욕 조절 효과를 위해 측정한 사료 섭취량에도 영향을 주지 않았으며, 간 조직 무게에도 영향을 미치지 않았다. 인슐린저항성과 포도당신생합성의 주요 지표인 공복혈당량 또한 혼합유산균 급여에 의해 변화 하지 않았다. 또한 혼합유산균은 심혈관질환의 지표로 사용되는 혈중 중성지방 및 총 콜레스테롤에 영향을 주지 않았으며, 체내 지방의 소화 및 흡수율에서도 영향을 미치지 않았다. 결론적으로, 고지방식이유도 비만 마우스를 이용하여 혼합유산균(Bf141 + Lb102)의 항비만 생리활성 을 검증한 결과, 유의미한 물리적, 대사적 표현형 개선은 검증되지 않았다. 따라서, 추후 개별 보다 다양한 혼합 조건 및 농도로 연구를 설계하여 혼합유산균의 항비만 효과를 검증할 필요성이 있다.

Dyslipidemia, defined as elevated triglyceride (TG), total- and LDL-C, and/or decreased HDL-C levels, is considered a principal risk factor for cardiovascular disease. The low-density lipoprotein receptor (LDLR) family has been considered a key player in the prevention of dyslipidemia. The LDLR family consists of cytoplasmic membrane proteins and plays an important role not only in ligand–receptor binding and uptake, but also in various cell signaling pathways. Emerging reports state that various functional ingredients dynamically modulate the function of the LDLR family. For instance, oats stimulated the LDLR function in vivo, resulting in decreased body weight and improved serum lipid profiles. The stimulation of LRP6 by functional ingredients in vitro activated the Wnt/β-catenin pathway, subsequently suppressing the intracellular TG via inhibition of SREBP1, PPARγ, and C/EBPα. Furthermore, the extract of Cistanchetubulosa enhanced the expression of the mRNA of VLDLR, followed by a reduction in the serum cholesterol level. In addition, fermented soy milk diminished TG and total cholesterol levels while increasing HDL-C levels via activation of LRP1. To summarize, modulating the function of the LDLR family by diverse functional ingredients may be a potent therapeutic remedy for the treatment of dyslipidemia and cardiovascular diseases.

High fructose corn syrup (HFCS) is a liquid sweetener of glucose-fructose monomer mixture, commonly known as replacement for sucrose (table sugar). HFCS was first applied to food companies in the early 1970s ever since there was a huge increase of its use worldwide, especially in beverage and processed food. While the metabolic and nutritional characteristics of HFCS have been widely studied, only recently has the role of HFCS in metabolic syndrome and other health issues emerged. Studies in many laboratories worldwide have built the evidence that excessive consumption of HFCS plays a crucial role in insulin resistance, dyslipidemia, obesity, hypertension, and kidney disease. This manuscript reviews the history, manufacturing process, and nutritional and metabolic traits of HFCS and describes its involvement in the pathogenesis of metabolic syndromes and obesity.

The Space structures may have large freedom in scale and form. And especially Hybrid structures are received much attention from the view points of their light weight and aesthetics. Hybrid systems are stable structures which are reticulated spatial structures composed of compressive straight members, struts and cables and Membranes. In this paper, The Hybrid Unit System are suggested using the Membrane and Cable elements based on the Tensegrity Unit system. Also, The Hybrid System of double-layered single curvature is presented. We analyze the force density method allowing form-finding for Tensegrity systems. And We analyze the shape analysis by the LARSH which is the program for nonlinear analysis.

Tensegrity systems are stable structures which are reticulated spatial structures composed of compressive straight members, struts and cables. But there are some difficulties concerning surface stability, surface formation and construction method. One of the ways to solve this problem reasonably is combination of tesile members and rigid members. This structure is a type of flexible strutural system which is unstable initially because the cable material has little initial rigidity. Therefore tensegrity structure need to be introduced to the Initial stress for the self-equilibrated system having stable state. The rigidification of tensegrity systems is related to selfstress states which can be achieved only when geometrical and mechanical requirements are simultaneously satisfied. In this paper, for the stabilization of tesnsegrity structure it is proposed the modified self-equilibrated equation and the range of the various geometrical parameter about unit system. And we generate the model of double layed single curvature arch using the new squew quadruplex unit system.

The basic systems of spatial structures such as shells, membranes, cable-nets and tensegrity structures have been developed to create the large spaces without column. But there are some difficulties concerning structural stability, surface formation and construction method. Tensegrity systems are flexible structures which are reticulated spatial structures composed of compressive members and cables. The rigidification of tensegrity systems is related to selfstress states which can be achieved only when geometrical and mechanical requirements are simultaneously satisfied. In this paper, the force density method allowing form-finding for tensegrity systems is presented. And various modules of unit-structures are investigated and discussed using the force density method. Also, a model of double-layered single curvature arch with quadruplex using supplementary cable is presented.