A 19-year-old male Siberian tiger was presented with inappetence and paralysis of hind limbs. In a computed tomography (CT) scan, intervertebral disk disease at L3–L4 was detected. Cardiac arrest occurred during the surgery. At autopsy, myxomatous mitral valve degeneration (MMVD) and eccentric hypertrophy of the left heart were noted. The diagnosis was congestive heart failure caused by MMVD. Microscopically, myocardial and pulmonary fibrosis were observed in addition to the disintegration of the fibrosa layer and accumulation of glycosaminoglycans and proteoglycans in the spongiosa layer of the mitral valve. This is the first case of congestive heart failure with MMVD in a Siberian tiger.

Smart factories can be defined as intelligent factories that produce products through IoT-based data. In order to build and operate a smart factory, various new technologies such as CPS, IoT, Big Data, and AI are to be introduced and utilized, while the implementation of a MES system that accurately and quickly collects equipment data and production performance is as important as those new technologies. First of all, it is very essential to build a smart factory appropriate to the current status of the company. In this study, what are the essential prerequisite factors for successfully implementing a smart factory was investigated. A case study has been carried out to illustrate the effect of implementing ERP and MES, and to examine the extensibilities into a smart factory. ERP and MES as an integrated manufacturing information system do not imply a smart factory, however, it has been confirmed that ERP and MES are necessary conditions among many factors for developing into a smart factory. Therefore, the stepwise implementation of intelligent MES through the expansion of MES function was suggested. An intelligent MES that is capable of making various decisions has been investigated as a prototyping system by applying data mining techniques and big data analysis. In the end, in order for small and medium enterprises to implement a low-cost, high-efficiency smart factory, the level and goal of the smart factory must be clearly defined, and the transition to ERP and MES-based intelligent factories could be a potential alternative.

유방조직 확장기(BTE)는 MR 금기로 분류되고 있으나 이전 연구들에서 제한적인 조건에서 MRI 검사가 가능함을 발표하였다. 본 연구는 미국재료시험 협회에서 권고하는 변위력과 토크뿐 만 아니라 뒤틀림을 측정하여 MR 안전성을 평가하였다. 3.0 T MRI 장치와 350 ㎖, 650 ㎖ BTE를 사용하였다. 변위력은 자기장이 가장 큰 지점에서 측정 기구에 BTE를 매달고 발생된 최대 변위각을 3회씩 측정하였다. 토크는 원형 용기에 생리식염수를 단계적으로 채운 BTE를 놓고 자기장에 의해 발생된 회전력을 45˚ 간격에서 정성적으로 측정하였다. 뒤틀림은 생리식염수를 최대로 채운 뒤 자성 밸브의 뒤틀림 각도를 포켓 경사계를 이용하여 두부, 어깨, 유방, 간, 골반이 중심일 때 유방 위치에서 각각 측정하였다. 측정 결과 변위각 은 350 ㎖의 경우 0 ㏄, 150 ㏄에서 각각 125˚, 54.3˚, 650 ㎖은 0 ㏄에서만 123.3˚로 MR 금기 기준을 초과했다. 토크는 350 ㎖의 경우 모두 +4로 측정되었고, 650 ㎖의 경우 450 ㏄ 생리식염수 미만에서는 모두 +4, 550 ㏄ 이상에서는 +1∼+4로 나타났으며, 일부를 조건을 제외하고 모두 MR 금기 조건을 초과했다. 뒤틀림은 350 ㎖의 경우 5˚∼80˚ 를 나타냈으며. 650 ㎖는 15˚∼90˚를 나타내어 환자에게 통증 유발 가능성을 확인했다. BTE의 변위각, 토크, 뒤틀림을 측정하여 MR 금기로 평가하였으며, 어떠한 조건하에서도 MR 환경에서 환자의 안전을 보장할 수 없다.

RAM represents reliability, availability, and maintenance, and is a key performance indicator that is utilized throughout the life cycle of the weapon system from the stage of requesting to disposal. If the RAM target value is set to a too high value, development may be delayed or development cost may be increased. If it is set to a too low value, frequent failures may occur during training, or a problem may arise that the number of available weapon systems is insufficient. The currently most used method to set the RAM target value is to write an operation mode summary and calculate it through an equation. However, as the definition of the operation mode is not standardized, different RAM target values may be set depending on the authoring organization. This study aims to analyze the current situation and suggest an alternative to this problem.

When considering military operations that require rapid response time, forward supply operation of various type of ammunition is essential. Also, t is necessary to supply ammunition in a timely manner before an ammunition shortage situation occurs. In this study, we propose a mathematical model for allocation of ammunition to ammunition storehouse at the Ammunition Supply Post (ASP). The model has several objectives. First, it ensures that the frequent used ammunition is stored in a distributed manner at a high workability ammunition storehouses. Second, infrequent used ammunition is required to be stored intensively at a single storehouse as much as possible. Third, capacity of the storehouse and compatible storage restriction required to be obeyed. Lastly, criticality of ammunition should be considered to ensure safety distance. We propose an algorithm to find the pareto-based optimal solution using the mathematical model in a reasonable computation time. The computational results show that the suggested model and algorithm can solve the real operational scale of the allocation problem.

본 연구는 다양한 항생제 내성을 갖는 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 19585 (STWT), S. Typhimurium KCCM 40253 (STKCCM), ciprofloxacininduced S. Typhimurium ATCC 19585 strains (STCIP), and S. Typhimurium CCARM 8009 (STCCARM)에 대한 phage의 흡착 및 용균 특성을 평가하였다. PBST-10, PBST-13, PBST-32, PBST-35, P-22, P-22 B1 phages는 narrow host range를 보였다. 숙주인 STWT, STKCCM, STCIP에 대한 phage 의 흡착률은 각각 47-85%, 58-95%, 61-93%였지만, STCCARM 에 대한 phage의 흡착률은 14-36%의 낮은 수준을 보였다. STWT, STKCCM, STCIP, STCCARM에 대한 phage burst size는 각 각 43-350, 37-530, 66-500, 24-500 plaque-forming unit (PFU)으로 다양하게 관찰되었다. P-22 B1을 제외한 모든 phage는 배양 초기에 STCIP숙주를 효과적으로 저해하였다. 이러한 결과는 항생제 내성균을 저해하기 위해 phage control system 개발에 유용한 정보로 활용될 것이다.

We determine the observing sites for eclipses of large magnitude recorded in ancient Chinese chronicles from 200 BCE to 900 CE, by adopting the difference between terrestrial time and universal time, ΔT, given by Morrison & Stephenson (2004). The records of solar eclipses with large magnitude are divided into four groups in accordance with the historical variations of the capital cities of ancient Chinese dynasties. We determine areas in which all the eclipses in each group, with an eclipse magnitude larger than a certain threshold value, could be observed. We find that these areas coincide with the historical capitals, which agrees with the general idea that the solar eclipses were observed at the capital of each dynasty. This result also veries the ΔT values during the period from 100 BCE to 400 CE, during which historical records of eclipses are so rare that the ΔT values can only be obtained by interpolating the long-term data. Moreover, we show that the eclipses described by the term Ji in East-Asian history are not all total eclipses; their mean magnitude is 0:96 ± 0:04. We find that complementary expressions, such as dark daytime and appearance of stars during the eclipse, strengthen the possibility that eclipses described by the term Ji were total. We also provide quantitative definitions for expressions such as `being not complete and like a hook', `being almost complete', `visibility of stars during the eclipse', and `darkness during an eclipse.' The literal meanings of these expressions are in agreement with the recent physical modeling of sky brightness during total eclipses provided by K¨onnen & Hinz (2008).

We report a massive outbreak of human Q fever cases, which occurred at totally 11 humans. The occurrence was related to a goat farm where Coxiella burnetii infection was diagnosed from goat tissues and environmental specimens. From January of 2018, continuous abortions from 6 goats occurred. Laboratory tests from 77 goat specimens for C. burnetii showed that 54 (70.1%) and 63 (81.8%) goats were positive by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The infection was also confirmed from the farmer, his wife and 9 persons from all 16 veterinary officials who had visited the farm for protective measures and preparing goat specimens for laboratory tests. The farm was found to be extensively contaminated with C. burnetii from the examination to the environmental specimens and epidemiological inspections, which might be the main source of C. burnetii infection to humans. The extensive contamination to the farm was derived from the uncareful handling of postpartum animal tissues or discharges by the farm owner. This report will contribute to the establishment of educational system on the biosecurity to novice farmers.

Background: Forward head posture (FHP) is common postural malalignment. FHP is described relatively extension to upper cervical and lower cervical is relatively flexion. Although several researchers mentioned the lower cervical flexion posture in FHP, most of the studies related to FHP is focused on the deep cervical flexor function. Objects: The purposes of present study is to compare the cervical strength (upper cervical extension [UCE], lower cervical extension [LCE], upper cervical flexion [UCF], lower cervical flexion [LCF]) between individuals with and without FHP. Methods: Fifty-one participants are recruited. Participants who have the craniovertebral angle (CVA) less than 48 degree were classified to the FHP group (n = 24) and the others were included in without FHP group (n = 27). The cervical strength (UCE, LCE, UCF, LCF) were measured using Smart KEMA strength sensor and the strength data was normalized by body weight. All strength measurement conducted at head and neck neutral position in sitting. Independent t-test was used to compare the cervical strength between individuals with and without FHP. Results: The mean value of CVA was greater in without FHP group than with FHP group (p < 0.000). The strength value of UCF (p < 0.002) and LCE (p < 0.001) was significant less in FHP group than without FHP group. But no significant differences were seen in the LCF and UCE strength between two groups. Conclusion: UCF and LCE weakness in FHP group should be considered to evaluate and manage the individuals with FHP.

The present study investigated the participation of D-serine and NR2 in antinociception produced by blockade of central erythropoietin-producing hepatocellular carcinoma (Eph) A4 (EphA4) signaling in rats with trigeminal neuropathic pain. Trigeminal neuropathic pain was modeled in male Sprague-Dawley rats using mal-positioned dental implants. The left mandibular second molar was extracted under anesthesia, and a miniature dental implant was placed to induce injury to the inferior alveolar nerve. Our current findings showed that nerve injury induced by malpositioned dental implants significantly produced mechanical allodynia; additionally, the inferior alveolar nerve injury increased the expression of D-serine and NR2 subunits in the ipsilateral medullary dorsal horn (trigeminal subnucleus caudalis). Intracisternal administration of EphA4-Fc, an EphA4 inhibitor, inhibited nerve injury-induced mechanical allodynia and upregulated the expression of D-serine and NR2 subunits. Moreover, intracisternal administration of D-amino acids oxidase, a D-serine inhibitor, inhibited trigeminal mechanical allodynia. These results show that D-serine and NR2 subunit pathways participate in central EphA4 signaling after an inferior alveolar nerve injury. Therefore, blockade of D-serine and NR2 subunit pathways in central EphA4 signaling provides a new therapeutic target for the treatment of trigeminal neuropathic pain.

이 연구는 위선의 실재와 그것이 우리의 ‘좋은 삶’에 대한 끊임없는 갈망과 갖는 연관성을 알아보고자 다음과 같은 세 가지 질문을 중심으로 다룬다: ‘위선 이란 무엇인가?,’ ‘위선과 연관된 문제에는 어떤 것들이 있는가?,’ 그리고 ‘위선 의 해결책은 무엇이며 어떻게 그것을 이룰 수 있는가?.’ 첫째로 최근 대중 문화 속 슈퍼히어로에 대한 관심이 급증한 사회적 현상의 맥락에서 덕과 위선의 언어가 우리의 현재 사회에 어떻게 위치해 있는지 알아본다. 둘째로, 플래너리 오코너의 두 작품을 통해 ‘위선적이지 않은 사람은 없으므로 누구나가 은총을 필요로 한다’는 개념이 어떻게 내러티브에 드러나는지 살펴본다. 셋째로 위선자들의 공통적인 특징으로 자아로부터의 분리와 자기 이해의 부족을 제시하고, 문학 작품에서 자주 표현되는 것처럼 특히 지성인들과 종교인들이 그러한 특징에 취약한 원인을 알아본다. 마지막으로 위선의 해결책으로 자신의 불완전함을 드러낼 수 있는 용기를 제안하며 자신과의 관계를 회복하는 데 있어 타인들과의 관계가 필수적임을 주장한다. 이것은 곧, 진정한 자아는 그 존재의 갈림이 전적으로 타인에게 맡겨질 때 비로소 드러난다는 것이다.

본 연구는 항생제 내성 Salmonella Typhimurium CCARM 8009을 저해하기 위한 phage와 항생제 조합처리의 효과를 평가하였다. 디스크 확산법과 액체배지 희석법에 의해 phage와 항생제의 상승 저해효과를 측정하였고 배양을 통한 항생제 내성 유도를 평가하였다. Phage를 처리한 cefotaxime, chloramphenicol, ciprofloxacin, erythromycin의 디스크의 저해 구역은 각각 13.6%, 19.3%, 12.7%, 78.8% 로 증가되었다. Phage와 항생제 조합 처리에 의해 tetracycline, chloramphenicol, ciprofloxacin, erythromycin, streptomycin의 최소생육억제농도는 각각 64, 4, 0.0078, 64, 256 mg/mL으로 감소되었다. Phage와 항생제의 조합 처리는 항생제 내성 S. Typhimurium CCARM 8009을 효과적으로 저해하였다 (4 log reduction). 본 결과는 phage와 항생제의 조합처리는 항생제 내성균을 제어하기 위한 방법으로 충분히 응용가치가 높음을 보여주고 있다.

As consumers have transformed into the influential entities in the recent consumption environment, it needs a new concept to describe their characteristics. Drawn on the notion of smart consumer experience, this study views the multiple traits of new consumers as consumer smartness. Therefore, elaborating the concept of consumer smartness, this study aims to develop its measurement and validate it by examining the relationship with external variables. Two online surveys were conducted by a professional survey company that had nationwide consumer panels. A total of 531 adult consumers who had purchased fashion goods online completed a self-administered questionnaires. A series of exploratory and confirmative factor analysis generated 21 measuring items with six underlying constructs of consumer smartness such as innovativeness, opinion leadership, self-disclosure, marketing literacy, dissatisfaction, and technology sophistication. In order to validate the measurement, this study conducted a Pearson’s correlation test and structural equation modeling analysis with consumer smartness and external constructs. The result shows that there was a significant positive relationship between consumer smartness and behavioral intentions online. In addition, consumer smartness influenced their shopping and sharing intention which supported the validity of new measurement of consumer smartness. This study provides a theoretical and empirical ground of understanding consumer smartness as new consumer characteristics in the changing environment of fashion retailing.

긴바수염반날개[Atheta (Bessobia) occulta (Erichson)] (신칭)를 한반도에서 처음으로 보고한다. 이 종에 대한 재기재, 체형사진 및 식별형질에 대한 삽화를 제시한다.

이 연구는 마릴린 로빈슨의 네 번째 소설 『라일라』에서의 주인공의 내적인 변화 과정을 살펴본다. 라일라가 깊은 고독과 궁핍, 그리고 버려짐의 아픔을 겪으며 묻게 되는 존재론적인 질문—“사는 게 왜 이런 식이지요?”—은 신학적인 의미를 내포한다. 한 인간이 그러한 질문을 던지게 되는 존재론적 조건을 고찰 하는 데 있어, “앎으로서의 무지(unknowing as knowing)”, “부재 속의 실재 (presence in absence)”와 같은 모순적인 개념을 적극 포용했던 크리스천 신비주 의자들의 전통을 되짚고, 그들의 기도의 삶과 라일라의 경험 간 유사성을 제안 한다. 이를 통해 라일라의 질문이 가진 새로운 의미의 가능성을 제시하고 “어 둠”의 경험이 “빛”을 경험하는 데에 필수적으로 전제됨을 주장한다. 또한 존 칼 뱅이 주창한 “하나님의 극장(the theatre of God)”으로서의 인간의 인식을 적극 차용하여 과거의 경험에 대한 기억, 중재 없는 성경 읽기, 에임스 목사와의 관계, 그리고 한 이방인과의 만남을 통해 그녀의 인식에 일어나는 미묘하나 점진적인 변화를 분석한다. 이 문학작품의 이러한 신학적 읽기는 몇몇 비평가들과 다르게 라일라의 변화에서 깊은 낙관론을 발견하게 하며, 인간의 고통과 무지 속에서도 삶을 긍정할 수 있는 가능성을 제시한다.