Tenebrio molitor beetles have been widely used in traditional and folklore medicines to treat various human diseases worldwide. Alzheimer’s disease (AD) is a neurodegenerative disorder and the most prevalent form of dementia in developed and developing countries. The human β-amyloid cleaving enzyme (BACE-1) is a target for AD treatments. This study was performed to determine BACE-1 inhibitory activity of 12 compounds that were extracted from T. molitor adults and their 65 related compounds using a fluorescence resonance energy transfer-based enzyme assay. The results were compared with those of two positive controls for BACE-1, the cell-permeable isophthalamide BACE-1 inhibitor IV and the natural BACE-1 inhibitor, epigallocatechin gallate (EGCG). Based on IC50 values, linoleic acid, ergosterol, palmitoleic acid, and tryptopol (28.41‒46.16 μM) were the most potent BACE-1 inhibitors and the anti-BACE-1 activity of these compounds was lower than either inhibitor IV (13.13 μM) or EGCG (1.12 μM). Multiple regression analysis of the anti-BACE-1 activities of compounds was examined using their IC50 values and the values of the physical parameters (molecular weight (MW), log P, and molecular refraction (MR)) for the 41 fatty acids (R2 = 0.674 (P = 0.044)) and 29 flavonoids (R2 = 0.587 (P = 0.063)). Correlation coefficient (r) analysis showed that MW, log P, and MR may be positively correlated with IC50 of the fatty acids (MW, r = 0.658; log P, r = 0.471; and MR, r = 0.713) and IC50 of the flavonoids (MW, r = 0.547; log P, r = 0.644; and MR, r = 0.591). Further studies will warrant possible applications of T. molitor adults as therapeutic BACE-1 blocker.

Tenebrio molitor beetles have been widely used in traditional and folklore medicines to treat various human diseases worldwide. This study was performed to determine radical scavenging activity of nine compounds that were extracted from T. molitor adults and their 64 related compounds using a 2,2-diphenyl-1-picrylhydrazyl assay. The results were compared with those of three positive controls, ascorbic acid, butylated hydroxytoluene (BHT), and epigallocatechin gallate (EGCG). Based on IC50 values, linolenic acid (77.65 μM) was the most potent antioxidant and the antioxidant activity of this compound was higher than that of either ascorbic acid, BHT or EGCG. The antioxidant activity of protocatechuic acid (IC50, 153.68 μM) and ascorbic acid did not differ significantly. The antioxidant activity of catechin (IC50, 192.32 μM) was higher than that of either BHT or EGCG. Multiple regression analysis of the antioxidant activities of compounds was examined using their IC50 values and the values of the physical parameters (molecular weight (MW), log P, and molecular refraction (MR)) for the 41 fatty acids (R2 = 0.729 (P = 0.031)) and 29 flavonoids (R2 = 0.521 (P = 0.054)). Correlation coefficient (r) analysis showed that MW, log P, and MR may be positively correlated with IC50 of the fatty acids (MW, r = 0.743; log P, r = 0.642; and MR, r = 0.815) and IC50 of the flavonoids (MW, r = 0.642; log P, r = 0.495; and MR, r = 0.643). Further studies will warrant possible applications of T. molitor adults as an antioxidant.

미국선녀벌레(Metcalfa pruinosa)는 외래 침입해충으로 조사가 시작된 2009년 이후 발생지역과 발생면적이 계속 증가하여 2018년에는 123개 시군구의 21,154ha에서 발생이 보고되고 있다. 미국선녀벌레는 농경지와 그 주변 산림지에서 활동하기 때문에 정부와 지자체간 협업을 통해 농림지 동시방제를 5월하순경(부화약충 대상)과 7월 중순경(성충 대상) 2회 실시하고 있다. 농촌진흥청에서는 미국선녀벌레의 기생천적인 선녀벌레집게벌(Neodryinus typhlocybae)의 안정적인 도입과 미국선녀벌레에 대한 생물적 방제원으로서 국내 정착을 위해 이탈리아 파도바대학과 국제협력사업을 2017년부터 수행하고 있다. 선녀벌레집게벌은 완주에서 월동이 가능하였으며 6월 초에 50%이상 우화를 하였다. 2018년도에 온실(완주)과 야외(수원, 태안)에서 증식하여 1,000여 개체 이상을 확보하였으며 도입천적의 안정적인 국내 정착과 확산 및 활용 방안에 대해 논의하고자 한다.

대한민국 첫 상업원전인 고리1호기는 40년간의 성공적인 운전을 끝내고 2017년 6월 18일 영구정지 되었다. 고리1호기는 본격적인 해체에 앞서 터빈건물에 폐기물처리시설 건설을 계획하고 있다. 각종 방사성폐기물은 폐기물처리시설에서 제염, 해체, 절단, 용융되어 자체처분 되거나 방사성폐기물 처분장으로 보내 진다. 해체폐기물 중 대형금속방사성폐기물은 주로 1차 계통측 기기들로 높은 방사능을 띄고 있어 해체활동 중 작업자의 피폭관리가 필요하다. 본 논문에서는 대형금속방사성폐기물 중 크기가 가장 크고 형상이 복잡한 증기발생기를 선정하여 RESRAD-RECYCLE 코드를 이용하여 작업자 피폭선량을 평가하고 저감화 방안을 수립 하고자 한다.

The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5% formalin-induced nociceptive behavioral responses was used as the pain model. Subcutaneous injection of 5% formalin significantly produced nociceptive responses by increasing the licking time during nociceptive behavior. Subsequent intraperitoneal injection of 100 mg/kg of eugenol led to a significant decrease in the licking time. However, low dose of eugenol (50 mg/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. Intrathecal injection of 30 μg of naloxone, an opioid receptor antagonist, significantly blocked antinociceptive effects produced by intraperitoneal injection of eugenol. Neither intrathecal injection of methysergide (30 μg), a serotonin receptor antagonist nor phentolamine (30 μg), an α-adrenergic receptor antagonist influenced antinociceptive effects of eugenol, as compared to the vehicle treatment. These results suggest that central opioid pathway participates in mediating the antinociceptive effects of eugenol.

본 논문에서 온라인 쇼핑몰에 적용을 목적으로 2차원 이미지에 기반한 가상 의상 착용 알고리즘을 설계하고 개발하였다. 기존의 가상착용 시스템은 3차원 의상 및 사용자 정보에 기반하여 비용과 시간이 많이 들어가는 문제를 가지고 있다. 본 시스템은 최근 급격히 발전된 딥러닝기술과 컴퓨터 그래픽스 기술을 활용한다. 우선, 패션영상을 시멘틱 분할 네트워크를 사용하여 옷과 신체를 영상분할하고, 자세 네트워크를 사용하여 의상과 사용자의 골격정보를 확보한다. 이 두 가지 정보를 바탕으로 의상의 골격위치와 사용자의 골격위치를 일치시킴으로서 변형에 필요한 변수를 확보하고 이를 바탕으로 영상 변형을 하여 가상착용을 수행한다. 실험결과 단순한 기하형태의 옷과 선 자세를 유지하는 패션사진과 사용자사진의 경우 만족스러운 변형 결과를 얻을 수 있었으나 다양한 의상의 형태나 자세를 갖는 경우 원만한 착용결과를 얻을 수 없었다. 완벽한 시스템은 존재할 수 없으므로 현재 기술로 적용 가능한 의상의 범위와 문제 상황을 자세히 분석하여. 이를 바탕으로 추후 연구를 방향을 설정할 수 있도록 하였다.

Hydraulic and drainage properties play an important role in the serviceability of a permeable block pavement system. A serious impediment to its performance is the accumulation of sediments over time. The deposition of these particles in block pavement joints reduces infiltration rate and drainage capacity, which, in the long run, decreases the system’s life span. In this study, laboratory experiments were conducted in order to investigate the influence of particle deposition on the hydraulic conductivity of a type of block pavement system, permeable stone paver, without maintenance or cleaning. Coefficients of permeability before and after addition of fine particles were evaluated using a developed permeability equipment with constant head frame. Three gradations of silica sand were used to simulate road clogging particles. An equivalent of eight years of sediment loading was applied to three identical permeable pavement samples. Laboratory test results showed an average of 77% reduction on the permeability due to particle accumulation.

With interconnecting voids, porous asphalt provides drainage of rainwater in vertical and lateral direction during rainfall. In addtition, it also offers remarkable advantages compare to traditional asphalt: reduce vehicle splash and spray behind, reduce night time surface glare in wet season and increase tire-pavement friction...On the other hand, the following aspects are recognized as disavantages: reduced performance, winter maintenance issues and high construction cost. For flexible pavement, dynamic modulus master curve is an important parameter in the mechanistic-empirical pavement design guide. In this study, the results of experiment of dynamic modulus test of porous asphalt are discussed for understanding well about the viscoelastic characteristics of porous asphalt.

Adenomyosis is a benign gynecological disease frequently affecting women of reproductive age. It has a negative impact on the quality of life, causing bleeding disorders, dysmenorrhea, chronic pelvic pain, and infertility. However, the molecular mechanisms involved in adenomyosis development remain unclear. This paper summarizes the reports found in the MEDLINE database on the molecular mechanisms involved in the development and progression of uterine adenomyosis. The literature search included the following terms: “adenomyosis,” “adenomyoma,” “pathogenesis,” “molecular mechanisms,” and “gynecological disorders.” Only peer-reviewed, English-language journal articles were included. This review focuses on the molecular genetics, epigenetic modifications, and pivotal signaling pathways associated with adenomyosis development and progression, which will provide insights into and a better understanding of its underlying pathophysiology.

과실파리류는 국내 60종의 검역 해충 가운데 42종을 차지하고 있다. 이들 대부분은 자연계 산물인 methyl eugenol (ME) 또는 raspberry ketone에 특이적으로 유인된다. 이들 유인물질을 파라핀 왁스를 이용하여 제형화하였고, 이를 대만에서 야외 유인 효과를 검증하였다. 이들 왁스 제형은 모두 델타트랩에 설치하고 8월 말경에 모니터링 한 결과 ME 왁스 제형은 오리엔탈과실파리(Bactrocera dorsalis)를 매일 60-80 마리 포획하 였다. 반면에 Cuelure 왁스제형은 오이과실파리(Bactrocera cucurbitae)와 B. tau를 유인하였다. 이러한 결과는 본 왁스제형이 이들 검역 해충에 대 한 국내 모니터링에 응용될 수 있다는 것을 제시하고 있다.

붉은뾰족반날개[Tachinus (Tachinus) javanus Cameron]를 한반도에서 처음으로 보고한다. 기재문, 외형사진과 식별형질의 그림 및 북방뾰 족반날개속의 검색표를제시한다. 큰갈색뾰족반날개[Tachinus (Tachinus) yezoensis Li]의 수컷형질을 추가하여 재기재한다.