Oral bacterial infections substantially affect the development of various periodontal diseases and oral cancers. However, the molecular mechanisms underlying the association between Fusobacterium nucleatum (F. nucleatum ), a major periodontitis (PT)-associated pathogen, and these diseases require extensive research. Previously, our RNAsequencing analysis identified a few hundred differentially expressed genes in patients with PT and peri-implantitis (PI) than in healthy controls. Thus, in the present study using oral squamous cell carcinoma (OSCC) cells, we aimed to evaluate the effect of F. nucleatum infection on genes that are differentially regulated in patients with PT and PI. Human oral squamous cell carcinoma cell lines OSC-2O, HSC-4, and HN22 were used. These cells were infected with F. nucleatum at a multiplicity of infection of 100 for 3 hours at 37℃ in 5% CO2. Gene expression was then measured using reverse-transcription polymerase chain reaction. Among 18 genes tested, the expression of CSF3, an inflammation-related cytokine, was increased by F. nucleatum infection. Additionally, F. nucleatum infection increased the phosphorylation of AKT, p38 MAPK, and JNK in OSC-20 cells. Treatment with p38 MAPK (SB202190) and JNK (SP600125) inhibitors reduced the enhanced CSF3 expression induced by F. nucleatum infection. Overall, this study demonstrated that F. nucleatum promotes CSF3 expression in OSCC cells through p38 MAPK and JNK signaling pathways, suggesting that p38 MAPK and JNK inhibitors may help treat F. nucleatum-related periodontal diseases by suppressing CSF3 expression.

본 연구는 방사형 K-공간 획득 기법 중 하나인 JET 기법을 적용하여 어깨관절 자기공명영상 검사에서의 움직임 인공물과 노이즈를 감소 효과를 평가하였다. 2023년 2월 1일부터 3월 31일까지 어깨관절 자기공명영상 검사를 받 은 35명을 대상으로 선정하여 후향적으로 분석하였다. 평가는 JET 기법 적용 여부에 따라 신호 대 노이즈 비, 평균 대 표준편차 비, 움직임 인공물 발생 여부에 대한 영상 평가를 수행하였다. JET 기법을 적용한 그룹에서는 신호 대 노이즈 비, 평균 대 표준편차 비, 움직임 인공물 발생 여부에 대한 영상 평가 값이 통계적으로 유의하게 높게 나타났다(p<0.05). 본 연구를 통해 어깨관절 자기공명영상 검사 시 JET 기법의 도입은 움직임 인공물의 감소뿐만 아니라 신호 대 노이즈 비와 평균 대 표준편차 비가 향상된 영상을 얻을 수 있음을 확인하였다. 이러한 결과는 JET 기법이 어깨관절 영상 취득에 유용하게 활용될 수 있을 것으로 판단되며, 더 나아가 다양한 부위에 적용되는데 있어 서도 기여할 수 있을것으로 예상된다.

This study explored the changes in senescence patterns and vase life of cut roses grown in summer and autumn, aiming to identify the relationship between harvest seasons and flower longevity. We analyzed gene expression profiles associated with lignin, pectin, ethylene, auxin, and sucrose transport to understand the molecular mechanisms underlying senescence symptoms, such as the bent neck, petal abscission, and petal wilting in cut rose flowers. Our results revealed season-dependent occurrences of bent neck and petal abscission, with higher incidence rates in autumn-harvested rose flowers. These increases in bent neck and petal abscission contributed to a shortened vase life for the cut flowers. Gene expression analysis indicated that elevated levels of ethylene biosynthesis genes and reduced expression of lignin, pectin biosynthesis, auxin response factor, and sucrose transport genes accelerated the increased senescence symptoms. Notably, the incidence rates of the bent neck were highly negatively correlated with the transcript levels of key genes involved in lignin and pectin biosynthesis, RhPRXPX and RhGAUT1, in pedicels. These findings contribute to our understanding of the molecular factors influencing the mechanical strength of flower pedicels and provide insights for postharvest strategies to enhance the ornamental value of cut flowers across seasons.

This study analyzed the impact of Higher-order resources on profit sustainability for domestic companies using a mathematical statistical model. Higher-order resources refer to resources that do not directly affect profits but influence other resources that directly contribute to profits. As a result of analysis using 30 years of actual data from more than 650 domestic companies, the average duration of competitive advantage including high-order resources was found to be about twice as long as the period suggested by the autoregressive model excluding high-order resources. Through this, if companies want to earn more profits over a long period of time than their competitors, they must not only possess resources that are more valuable, rare, difficult to imitate, and non-substitutable compared to their competitors, but also that higher-order resources can contribute to changes in these resources over time. It was confirmed that it must lead the long-term profit difference. High-level resources include strategic planning, mergers and acquisitions (M&A) capabilities, and good forecasting.

본 논문에서는 빙하가 녹아 갈라져서 떠내려 온 새끼 펭귄이 다시 펭귄 무리로 되돌아가기 위 해서 길을 찾아 나서는 퍼즐 어드벤처 게임을 제안한다. 플레이어 40명의 로그 기록과 설문지 를 분석한 결과를 바탕으로 제안하는 게임의 특징을 살펴보고자 한다. 첫째, 제안하는 게임은 새끼 펭귄이 얼음 덩어리를 밀어서 길을 만들어 이동하는 직관적인 규칙을 제공한다. 로그 기 록에서 플레이 평균 시간은 19분이며, 이를 19개의 리스폰 지점으로 나누면, 구간별 플레이 평균시간은 1분이다. 설문에서 게임 목표 명확성은 4.45점, 게임 난이도는 4.16점을 받았다. 둘째, 제안하는 게임은 가마우지가 새끼 펭귄에게 도움말을 제시하는 등 유용한 정보를 친절 하게 제공한다. 전체 플레이 평균 시간은 baseline이 24분이고, kinder UI가 19분이다. kinder UI에서 새끼 펭귄이 얼음 덩어리를 덜 밀고, 게임 재시작을 덜 하고, 더 빨리 상호작 용하여, 문제를 빨리 해결한다. 설문에서 게임 스토리 이해는 4.15점, 유용한 정보는 4.45점을 받았다. 셋째, 제안하는 게임은 남극과 유사한 환경을 제공하여 몰입도를 상승시킨다. baseline에 비해서 kinder UI에서 다양한 게임 오브젝트와 더 적극적으로 상호작용을 시도하 고, 미션 완료 후 더 오랫동안 오로라를 지켜봤다. 설문에서 게임 캐릭터 선호도는 4.56점, 게 임 환경 만족도는 4.22점을 받았다.

Background: Various treatments are being tried for lumbar neuropathy. Among them, neural mobilization aims to reduce peripheral nerve sensitivity by stimulating them directly. Similarly, applying kinesiotape stimulates skin and joint receptors around the nerves, thereby affecting nerve function and movement. Objectives: To investigated the effect of low back pain on the neural mobilization and kinesiotaping. Design: Randomized controlled trial. Methods: Thirty patients with chronic low back pain were randomly allocated to three groups: the neural mobilization exercise with kinesiotaping group (NEKTG, n=10), the neural mobilization exercise group (NEG, n=10), and the kinesiotaping group (KTG, n=10). Each group performed six intervention sessions over two weeks. The results were analyzed by measuring the numeric pain rating scale (NPRS) and straight leg raise (SLR) before and after the intervention in each group. Results: NEKTG, NEG, and KTG all indicated a significant decrease in the back pain index before and after the intervention. However, there were no differences observed between the three groups. The SLR angles before the experiment were identical across the three groups. The SLR angles before and after the intervention were as follows: the SLR angle significantly increased in NEKTG. Furthermore, there was a significant increase in the SLR angle in NEKTG compared to both NEG and KTG. Conclusion: Neural mobilization combined with kinesiotaping provided better therapeutic effects regarding pain reduction and neurodynamic improvement compared to alone kinesiotaping and mobilization with chronic low back pain.

Background: Mobilization with movement (MWM) is an effective intervention for increasing range of motion (ROM) and function without pain. Objectives: The purpose of this study is to comprehensively characterize the functional effects of MWM applied to the ankle joint in patients with stroke. Design: Systematic Review and Meta-analysis. Methods: International electronic databases, CINAHL, Embase, MEDLINE, PubMed, and Google scholar were included and identified after review by two investigators in July 2023 according to PRISMA guidelines. Data were synthesized using software provided by Cochran and analyzed using a random effects model with reweighting to account for heterogeneity between participants. Results: After excluding duplicate studies, 14 of the 19 articles screened through the abstracts were excluded, resulting in a total of five studies involving 109 participants with stroke. MWM showed significant differences in ankle ROM [overall effect (Z=3.27, P=0.00)], gait speed [overall effect (Z=3.33, P=0.00)], and cadence [overall effect (Z=2.49, P=0.01)]. Conclusion: The results of the meta-analysis confirmed that MWM is effective in improving ankle ROM and gait parameters in patients with stroke.

Background: The forward head posture acts as a factor that can cause various neurovascular and musculoskeletal dysfunctions. But searching for a study on quality of life for patient with forward head posture was challenging. Therefore, this study aims to find the factors that most affect the quality of life in patients with forward head posture. Objectives: The purpose of this study was to investigate the correlations between the cranio-vertebral angle (CVA), neck disability index (NDI), pain, and sternocleidomastoid (SCM) thickness of patients with forward head posture and the quality of life of the patients and to figure out important factors that affect the quality of life of the patients with forward head posture. Design: Cress-sectional study. Methods: To measure the CVA, the angle at which the visible protrusion of C7 and the ear bead were connected was measured, and the neck disorder index was evaluated using the Korean version of NDI. The degree of pain of the subject was measured using a visual-analog scale (VAS). The SCM thickness was measured using an ultrasound imaging device, and the quality of life was evaluated using the Korean version of the World Health Organization quality of life questionnaire (WHOQL-BREF). Results: A significant predictive model showing 88% explanatory power for the dependent variable was confirmed, with an appropriate regression equation being found. The factor that most affected patients' quality of life in the forward head posture was confirmed by the SCM thickness. Conclusion: When applying an intervention to improve a patient's quality of life for patient with forward head posture, an intervention method that improves the SCM thickness should be recommended.

Background: Self-myofascial release using a foam roller has short-term effects for improving muscle function and joint range of motion (ROM) and reducing delayed onset muscle soreness (DOMS) after exercise. Objectives: The purpose of our study was to examine the muscle physiological changes for each set in self-myofascial release of the hamstring muscles using a foam roller in order to provide basic data for the most effective program composition for improving muscle tension, stiffness, and flexibility of the hamstring muscles. Design: A quasi-experimental clinical trial. Methods: To confirm the effect of self-myofascial release of the hamstring muscles using a foam roller, muscle tone and stiffness of the hamstring muscles were measured. As an intervention method, the study subject performed four sessions of self-myofascial release by moving a foam roller back and forth on the posterior thigh muscle of the right leg. Results: There were statistically significant changes in the stiffness of the biceps femoris and the flexibility of the hamstring muscles. Conclusion: Self-myofascial release with foam rolling is an effective intervention method for increasing hamstring flexibility and ROM, and it is recommended as effective to perform self-myofascial release for three to four sessions to maintain normal muscle tone and stiffness of the hamstring muscles.

Background: The reduction in physical activity in stroke patients weakens their health and lowers their quality of life. There is a need for the development of effective exercise programs to enhance the physical activity of chronic stroke patients. Objectives: The purpose of this study is to investigate the effects of a rehabilitation sports program using Proprioceptive Neuromuscular Facilitation (PNF) on the body composition, physical function, and quality of life of stroke. Design: Single group study. Methods: This study was conducted on 9 chronic stroke patients. The exercise program, which applied PNF, was carried out in group sessions twice a week for 50 minutes each over 8 weeks. Participants were assessed before and after the exercise program using InBody, Fugl-Meyer Assessment for Upper Extremity (FMA-UE), Grip Strength, 10-Meter Walk Test (10MWT), Timed Up and Go Test (TUG), Functional Reach Test (FRT), and completed the 36-Item Short Form Health Survey (SF-36) questionnaire. Statistical analysis was performed using paired t-tests for pre- and post-exercise comparisons and the Wilcoxon signed-rank test for evaluating the effects of the exercise program. Results: The results of this study showed differences in weight (P>.05), BMI(P>.05), body fat (P>.05), FMA-UE (P<.05), Grip Strength (P<.05), 10MWT (P<.05), TUG (P<.05), FRT (P<.05), SF-36 (P<.05). Conclusion: This suggests that the rehabilitation sports program using PNF can be used as an exercise program to enhance physical activity, improving physical function and quality of life in chronic stroke patients.

Background: Among the various rehabilitation methods for stroke patients, one method involves the use of vibration. Recently, vibration foam rollers, combining vibration with foam rolling, have been developed and are widely used. Objectives: The purpose of this study was to investigate the effects of vibration foam rolling on ankle range of motion (ROM), and gait speed in patients with stroke. Design: A randomized controlled trial. Methods: Thirty stroke patients volunteered to participate and were randomly assigned to the vibrating foam roller group (n=15) and the non-vibrating foam roller group (n=15). Active dorsiflexion ROM, and 10-meter walk (10MW) were used to evaluate ankle ROM, and gait speed before and after each exercise. The two groups performed a 30-minute foam roller exercise program. The non-vibrating foam roller group performed the same exercise program as the vibrating foam roller group, but without vibration. Results: The within-group change in active dorsiflexion ROM after the exercise was significant for both the vibrating foam roller group and the non-vibrating foam roller group (P<.05). The within-group change in 10MW after the exercise was significant for the vibrating foam roller group (P<.05), while it was not significant for the non-vibrating foam roller group (P>.05). Additionally, there was no significant difference in active dorsiflexion ROM and 10MW between the vibrating foam roller group and the non-vibrating foam roller group (P>.05). Conclusion: This study confirmed that a vibrating foam roller exercise program immediately improves ankle ROM and gait speed in stroke patients.

Background: Interventions for acute low back pain include exercise therapy such as stretching, aerobic exercise, and sling exercise. Another treatment method for back pain is soft tissue release. Soft tissue release is a relaxation method that improves balance while allowing tension tissues to relax as much as possible. Objectives: To investigated the effect of acute low back pain on the massage ball exercise. Design: Randomized controlled trial. Methods: The twenty-eight subjects were randomly allocated to the Massage ball exercise with TENS group (MBETG, n=14) and the transcutaneous electrical nerve stimulation group (TG, n=14). For MBETG, massage ball exercise (BALLance Dr. Tanja Kühne method) was applied for 25 minutes followed by TENS for 15 minutes. The TG group applied TENS for 40 minutes. Each group conducted the intervention three sessions. The results were analyzed by measuring the numeric pain rating scale (NPRS), surface electromyography (%MVIC), and Oswestry disability index (ODI) before and after the intervention in each group. Results: Significant reduction was observed for NPRS and ODI in the MBETG (P<.05). And Significant higher was observed for %MVIC of the Erector spinae in the MBETG (P<.05). The NPRS and ODI in the MBETG were decreaed than the TG (P<.05). Conclusion: Massage ball exercise to patients with acute back pain will be effective in reducing pain, increasing muscle activity, and improving functional disability.

Since the decrease of skid resistance of the road surface due to the effects of hydroplaning increases the ratio of vehicle crashes significantly, it is important to predict water film thickness (WFT). Tined is one of the widely used textures for concrete pavements. Since previous WFT models have been developed based on the asphalt pavement texture and broom concrete, it may not give reliable predictions for Water film thickness for tinned concrete. Furthermore, surface flow on tined texture may show hydraulically different characteristics due to the geometric characteristics of tined texture. This study aims to propose a reliable water film thickness prediction model for tined concrete. Three test slabs including a smooth surface, a tined surface with 16mm spacing, and a tined surface with 25mm spacing were prepared. WFTs of the test slab were measured for various conditions such as pavement slope (0-10%), rainfall intensity (0-130mm/h), and drainage path length (0-5m). A statistical model was proposed to predict water film thickness (WFT) as a function of pavement slope, rainfall intensity, drainage path length, and mean texture depth. This model exhibits strong agreement with the experimental test results. The GWNU prediction model consistently provides reliable predictions with the actual WFT for tined concrete pavement. Conversely, the previous equation consistently underestimated the water film thickness, notably on tined surfaces with 16 mm and 25 mm spacing, due to the occurrence of viscous flow along the tined lines.

The strength criteria is the acceptable strength for allowable a vehicle start on a concrete pavement at an early age without causing significant damage. The different agencies have provided the strength criteria based on empirical judgement. To make more comprehensive, the ACI specification provided strength criteria by consideration traffic conditions, slab thicknesses, and slab support based on the concept of damage. However, its neglected to consider the damage caused by curling stress due to temperature gradient in concrete pavement. This research aims to provide a strength criteria for opening traffic on concrete pavements while taking into account the damage caused by curling stress and traffic loading. The tensile stress at critical locations was determine due to curling and traffic loads every hour of early age throughout different seasons. The fatigue damage taken throughout early age was assessed. After this procedure, the strength criteria was established as the evaluated damage that did not exceed an acceptable limit. Accordingly, the strength criteria for opening traffic was determined to ensure that the specified damage level existed subject to the construction season, construction period, traffic type, slab thickness, and slab support of concrete pavement.

본 논문의 목적은 한국이 직면한 뉴테러리즘 양상과 위협 요인을 분석해보고, 선제적으로 대응할 수 있는 과제에 대해 제시해 봄에 있다. 현재 한국은 포괄적 안보상황 하에서 대중과 다중이용시설 대상 무차별적 공격의 사전 차단 및 대량살상 등 전방위적으로 테러위협에 대응하고 있다. 이에 이 논문에서는 테러 수단의 첨단화 및 고도화되고 있는 뉴테러리즘에 대해 선제적으로 국가 및 국민적 인식을 강화하고 취약점 보완을 위해 법률적, 제도적 대응 방안을 제시했다. 또 포괄적 안보 상황을 반영하여 국내 테러 양상을 분석하고, 테러예방시스템 구축을 위한 통합방위법 및 테러방지법의 상호 연계성과 사법집행 강화를 위한 근거를 마련해야 한다. 특히 AI 기반의 테러예방 및 대응 시스템 등 4차 산업혁명의 신기술 적용을 토대로 테러위협을 선제적 으로 차단하고 이 같은 기술을 활용하는 대테러업무 담당자를 대상 으로 교육훈련을 강화할 수 있는 방안 역시 마련해야 한다.

본 연구는 한국어 학습자들이 자신들의 언어학습 신념이 그들의 전반 적인 언어학습과 새로운 환경에 적응하는 것에 어떠한 관계가 있는지를 찾기 위함이 목적이다. 여섯 명의 한국대학교에 재학 중인 외국인 유학 생들을 대상으로 그들의 언어학습 신념에 대한 인터뷰가 진행되었다. Horwitz의 BALLI 문항을 기반으로 한 반구조적 인터뷰가 진행되었으며, 그들의 답변은 외국어 능력, 언어학습의 어려움, 언어학습의 본성, 학습 과 소통전략, 동기와 기대 등의 주제를 기반으로 비슷한 패턴을 보이는 항목별로 구분되어졌다. 연구 결과는 외국인 유학생들은 그들의 한국어 실력이 향상될수록 자신감을 가졌으며, 그들은 문화에 대한 학습이 언어 학습에 중요한 부분이라는 것을 인지했다. 또한, 가장 효과적인 학습법은 실제적인 상황과 사람들과 어울리는 것을 꼽았으며, 그들은 대학 졸업 이후에도 한국에 남아 있기를 희망했다.

본 연구는 중국 무용 전공 대학생의 유년시절 신체활동 태도가 무용 전공 선택동기와 무용 지속의도에 미치는 영향을 면밀히 살펴보고자 하 였다. 이를 위해 중국 산시성(陕西省) 시안(西安) 지역의 무용 전공 대학 생 500명을 통해 설문지를 수집하였다. 수집된 설문지는 SPSS 25.0 이 용하여 경향 분석, T-test 분석, Scheffe 분석, Pearsn의 상관관계분석, 단계적 중다회귀분석을 수행하였다. 본 연구결과 무용전공 대학생의 유 년시절 신체활동태도는 무용전공 선택동기 및 무용지속의도에 유의미한 영향력이 있는 것으로 나타났다. 이를 통해 아동의 신체발달을 지원하는 프로그램을 개발하는데 필요한 기초정보를 제공하고자 하며 무용 전공 대학생의 무용 지속의도를 높일 수 있는 교육과정을 개발하는 데에도 도 움을 주고자 한다.

In order to assess the relative importance of providing rural life services for the sustainability of rural communities and determine their prioritization, this study employed Analytic Hierarchy Process (AHP) to derive the relative importance of sectors and items in the realm of life services influencing the quality of rural life. A survey was conducted with three groups of experts. Group I consisted of experts in rural life services and rural environmental research (22 individuals), Group II included government officials responsible for implementing rural agreements in pilot areas (18 individuals), and Group III comprised executives from the Rural Life Improvement Association and 4-H organization working towards improving rural life and society (20 individuals). The analysis results revealed the following facilities as top priority in their respective categories: ‘National and Public Childcare Centers’ for ‘Childcare,’ Elementary and Middle Schools for ‘Education,’ Senior Welfare Facilities for ‘Welfare,’ Cultural Centers and Local Cultural Facilities for ‘Culture,’ Public Sports Facilities for ‘Sports,’ Emergency Medical Services for ‘Healthcare,’ Commercial Facilities in daily routines for ‘Commercial and Residential Services,’ Emergency Safety Agencies for ‘Administration and Security,’ and rural village Shelter for ‘Leisure and Rest.'

Nanoparticles are commonly used to avoid the opaque white color of TiO2 based sunscreen. However, a dispersing agent is typically required because of the tendency of the nanoparticles (NPs) to agglomerate. Stearic acid is one kind of dispersing agent often used for sunscreen products. However, according to the MSDS data sheet on stearic acid, stearic acid is highly hazardous to aquatic life and causes irritation on human skin. To avoid this problem, in this study a safer organic dispersing agent extracted from Korean seaweed has been studied to disperse TiO2 nanoparticles, and further use as an active agent in sunscreen products. The presence of phytochemicals in seaweed extract, especially alginate, can disperse TiO2 nanoparticles and improve TiO2 dispersion properties. Results show that seaweed extract can improve the dispersion properties of TiO2 nanoparticles and sunscreen products. Reducing the agglomeration of TiO2 nanoparticles improves sunscreen properties, by making it less opaque white in color, and increasing UV protection value. It was also confirmed that adding seaweed extract into sunscreen products had no irritating effects on the human skin, making it more desirable for cosmetics application.

Plants synthesize antioxidant compounds as a defense mechanism against reactive oxygen species. Recently, plant-derived antioxidant compounds have attracted attention due to the increasing consumer awareness in the heath industry. However, traditional methods for measuring the antioxidant activity of these compounds are time-consuming and costly. Therefore, our study constructed a quantitative structure-activity relationship (QSAR) model that can predict antioxidant activity using graph convolutional networks (GCN) from plant structural data. The accuracy (Acc) of the model reached 0.6 and the loss reached 0.03. Although with lower accuracy than previously reported QSAR models, our model showed the possibility of predicting DPPH antioxidant activity in a wide range of plant compounds (phenolics, polyphenols, vitamins, etc.) based on their graph structure.