다양한 동물 모델이 인간 질병, 의약품의 효능 및 작용 메커니즘을 연구하는 데 사용되고 있다. Zebrafish(Danio rerio)는 여러 가지 장점이 있어 인간 질병에 대한 중개 연구의 모델로 점점 더 폭넓게 활용되고 있다. 본 논문은 Pubmed, Google Scholar, Scopus에서 2020년 12월까지 최근 10년간 zebrafish 모델, 천연물(한약), in vivo 스크리닝의 키워드를 사용하여 저널에 게재된 논문을 검토하여 필 요한 정보를 얻었다. 이 리뷰에서 우리는 천연물(한약) 연구에 대한 다양한 제브라피쉬 질병 모델의 최 근 경향에 대해 논의하였다. 특히, 암, 안질환, 혈관 질환, 당뇨병 및 합병증, 피부질환에 중점을 두었고, zebrafish 배아를 사용하여 이들 질병에 대한 의약품의 분자 작용 메커니즘에 관해 언급하였다. Zebrafish는 실험실에서 임상 연구까지의 격차를 줄이는 데 중추적 역할을 할 수 있는 중요한 동물 모 델이다. Zebrafish는 의약품이나 화장품 개발, 질병의 병인론을 이해하기 위해 사용되고, 이로 인해 생의 학 연구에서 설치류의 사용을 줄이는 데 크게 기여하고 있다.

The goal of this study was to develop a curriculum based on practice and job competency, reflecting opinions on the required job competence of nail practitioners and professionals related to nail beauty. Through in-depth interviews with nail experts, the research focuses on developing nail beauty competency-based curriculum and curriculum profiles that reflect practitioners’ needs of job competence in the field. In-depth interviews with 11 field experts and surveys of 154 people were conducted to develop a competency-based curriculum for beginner nail hairdressers. The results of this study show that the existing 38 National Competency Standards (NCS) job competencies were reduced to 21 job competencies. In addition, based on the common opinions of experts who reflect the current trend, two tasks on “eyelashes” and “waxing” were added, and they were modified and supplemented with 23 core competencies. The development of a competency-based curriculum and educational programs for nail beauty was performed based on the requirements of the core competencies investigated and the development of a systematic map for the core competencies of beginner nail technicians and hairdressers. In conclusion, the need for professional education and training for nail hairdressers is growing, and it can be seen that a curriculum building multi-faceted abilities is needed for their qualifications as experts. This study found that it is necessary to develop interpersonal communication skills that include marketing elements other than practical skills such as personality and customer response methods in the nail beauty curriculum.

This study aims to develop the designs and patterns of yoga tops that are better adjusted to suit females in their 30s and 40s. After conducting a comparative analysis of three different popular yoga garments, one yoga top currently on the market was selected. Subsequently, a fit evaluation was conducted on Trail 1-garment α, which was developed body analysis performed based on selected yoga top C, followed by the production of the Trial 2 garment after making adjustments according to the comparative observation results. Based on these results, garment C with the longest top length was evaluated as the best. The results of the evaluation of appearance and fit conducted of Trial 1-garment α compared to those of C showed that Trial 1-garment α was superior in both evaluations. Trial 2-garment β was produced after making improvements on Trial 1-garment α and then placed under identical comparative evaluation condition as Trial 1-garment α. Results showed a significant improvement compared to Trial 1-garment α, and the Trial 2 garment with an additional arm pattern was shown to be superior in shoulder strap width stability, shoulder strap pressure, chest stability, degree of waist pressure, waist comfort, general fitting, and supportiveness.

The purpose of this study is to develop Korean clothing designs that can satisfy future consumer’s needs based on the elements extracted through the content analysis method in a study on the design elements expressed in traditional outfits in the 2010s. To this end, data analyzing Hanbok in wedding magazines were used, and after extracting design elements, research methods for empirical design development were used. After subclassifying the major design elements, factors with a steady increase in frequency and appearance rate were identified. Through this, five elements capable of aesthetic sampling were extracted by complex expression methods and expressed in a total of seven combinations. The types extracted from the design elements are items, silhouette, top shape, skirt shape, skirt length, mixed items with increasing frequency. In the element of color, the adjacent color harmony, which showed the highest frequency of color, and the white-blue harmony, which showed an increase among them, were extracted. When using materials, top and skirt have similar usage rates of the same and different materials, so both contents were extracted, and many patterns were arranged in the top and the whole, but these three were extracted because there were increasing cases where there were no patterns. In the case of decoration, embroidery, pintuck, sakdong, applique, lace, ribbon on the top, silver foil and print on the skirt were extracted. Through this study, it was possible to propose a future Korean costume design model.

On October 22, 2021, the Ministry of Commerce of the People’s Republic of China (PRC) promulgated the Development Plan for the Utilization of Foreign Capital during the 14th Five-Year Period. The plan has attracted wide attention from investors and scholars at home and abroad. The global economic recovery is full of unpredictable challenges due to the spread of Covid-19, so absorbing foreign investment is critical to the economic development in most countries. The plan was based on the 14th Five-Year Plan for National Economic and Social Development and the Outline of Long-term Objectives for 2035. China is changing the direction of attracting investment from manufacturing industry to service industry. This article discusses China’s current utilization of foreign capital and analyzes the newly promulgated plan, including its key features, overall objectives, and basic tasks. It also examines the opportunities and challenges China faces in its future utilization of foreign capital.

This paper aims to examine the progressive development process of the ASEAN under the UN 2030 Agenda for sustainable development. As of 2022, the ASEAN Member States have a total population of 622 million people and a combined GDP of USD 3.2 trillion. The ASEAN’s main focus is integration by connectivity which has been facilitated by “the ASEAN Way.” The ASEAN connectivity was upgraded into a single community through the ASEAN Vision 2020 comprehensively formalized by the Bali Concord II in 2003. The ASEAN has been geographically expanding towards Northeast Asia (ASEN+3) and then Oceania with India (ASEAN+6). It was also connected to the Regional Comprehensive Economic Partnership (RCEP) which is the biggest mega FTA in the contemporary world. With the Vision 2025, furthermore, the ASEAN Community reset its direction to sustainable development goals which are the main objective to attain for the Association under the Master Plan 2025.

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is an N6-methyladenosine (m6A) RNA modification regulator and a key determinant of premRNA processing, mRNA metabolism and transportation in cells. Currently, m6A reader proteins such as hnRNPA2/B1 and YTHDF2 has functional roles in mice embryo. However, the role of hnRNPA2/B1 in porcine embryogenic development are unclear. Here, we investigated the developmental competence and mRNA expression levels in porcine parthenogenetic embryos after hnRNPA2/B1 knock-down. HhnRNPA2/B1 was localized in the nucleus during subsequent embryonic development since zygote stage. After hnRNPA2/B1 knock-down using double stranded RNA injection, blastocyst formation rate decreased than that in the control group. Moreover, hnRNPA2/B1 knock-down embryos show developmental delay after compaction. In blastocyste stage, total cell number was decreased. Interestingly, gene expression patterns revealed that transcription of Pou5f1, Sox2, TRFP2C, Cdx2 and PARD6B decreased without changing the junction protein, ZO1, OCLN, and CDH1. Thus, hnRNPA2/B1 is necessary for porcine early embryo development by regulating gene expression through epigenetic RNA modification.

Sperm cryopreservation is a fundamental process for the long-term conservation of livestock genetic resources. Yet, the packaging method has been shown, among other factors, to affect the frozen-thawed (FT) sperm quality. This study aimed to develop a new mini-straw for sperm cryopreservation. In addition, the kinematic patterns, viability, acrosome integrity, and mitochondrial membrane potential (MMP) of boar spermatozoa frozen in the developed 0.25 mL straw, 0.25 mL (minitube, Germany), or 0.5 mL (IMV technologies, France) straws were assessed. Postthaw kinematic parameters were not different (experiment 1: total motility (33.89%, 32.42%), progressive motility (19.13%, 19.09%), curvilinear velocity (42.32, 42.86), and average path velocity (33.40, 33.62) for minitube and the developed straws, respectively. Further, the viability (38.56%, 34.03%), acrosome integrity (53.38%, 48.88%), MMP (42.32%, 36.71%) of spermatozoa frozen using both straw were not differ statistically (p > 0.05). In experiment two, the quality parameters for semen frozen in the developed straw were compared with the 0.5 mL IMV straw. The total motility (41.26%, 39.1%), progressive motility (24.62%, 23.25%), curvilinear velocity (46.44, 48.25), and average path velocity (37.98, 39.12), respectively, for IMV and the developed straw, did not differ statistically. Additionally, there was no significant difference in the viability (39.60%, 33.17%), acrosome integrity (46.23%, 43.23%), and MMP (39.66, 32.51) for IMV and the developed straw, respectively. These results validate the safety and efficiency of the developed straw and highlight its great potential for clinical application. Moreover, both 0.25 mL and 0.5 mL straws fit the present protocol for cryopreservation of boar spermatozoa.

With the continuous prosperity and development of the marine industry, the number of ships is increasing while greenhouse gas emissions are rising. In order to meet the relevant international ship emission regulations, the solution of developing electric ships is proposed. As the core device of the electric ship propulsion system, the maturity and applicability of power battery technology play a key role in the development of the electric ship. This article introduces the principles and advantages of the fuel cell, lithium-ion battery as well as supercapacitor battery, respectively, and analyzes the application status and challenges of power batteries in existing electric ships. The development direction and problems to be solved of power battery in current and future ship applications are put forward, which can provide a reference for further research.

This study intends to present a traffic node-based and link-based accident prediction models using XGBoost which is very excellent in performance among machine learning models, and to develop those models with sustainability and scalability. Also, we intend to present those models which predict the number of annual traffic accidents based on road types, weather conditions, and traffic information using XGBoost. To this end, data sets were constructed by collecting and preprocessing traffic accident information, road information, weather information, and traffic information. The SHAP method was used to identify the variables affecting the number of traffic accidents. The five main variables of the traffic node-based accident prediction model were snow cover, precipitation, the number of entering lanes and connected links, and slow speed. Otherwise, those of the traffic link-based accident prediction model were snow cover, precipitation, the number of lanes, road length, and slow speed. As the evaluation results of those models, the RMSE values of those models were each 0.2035 and 0.2107. In this study, only data from Sejong City were used to our models, but ours can be applied to all regions where traffic nodes and links are constructed. Therefore, our prediction models can be extended to a wider range.

국제해사기구(IMO)는 국제해운 분야의 온실가스(Green House Gas, GHG) 감축을 위하여 각국의 기술 개발 및 에너지 효율성 제 고에 관한 정책 시행을 적극적으로 권장하고 있다. 이러한 IMO의 환경규제와 관련된 정책들은 해운 분야 전반에 큰 영향을 미치고 있으 며, 선주들에게도 막대한 부담으로 작용하고 있다. 선박에서 발생하는 GHG 배출을 억제하기 위한 가장 합리적인 방안은 탄소제로배출 (Zero Emission) 선박의 개발로 귀결된다. 즉 친환경 연료로 추진하는 연료전지선박(Fuel Cell Ship, FCS)의 개발이 IMO의 규제를 벗어날 수 있는 대안인 것이다. 아시아, 북미, 유럽 등의 각국에서는 독자적으로 PEMFC를 개발 및 생산하여 국제공인등록 기관으로부터 형식승인 인증을 획득함으로써 국제표준화의 선점을 추구하고 있다. 현재 다양한 연료전지(Fuel Cell, FC) 중에서 선박용으로 권장하는 것은 크게 고 분자전해질 연료전지(PEMFC), 용융 탄산염 연료전지(MCFC) 및 고체산화물형 연료전지(SOFC) 등의 세종류가 있다. 본 연구에서는 글로벌 FC 시장에서 지속적인 성장이 예상되는 PEMFC를 대상으로 하여 국내외 개발 동향, 제조업체별 규격, 성능 및 선박에 적용한 실증적 사례 를 분석하였다. 그리고 PEMFC를 선박에 적용할 경우, 고려해야 할 사항과 개발 방향에 관하여 제안하고자 하였다.

해양사고의 감소를 위하여 국제해사기구(IMO) 체약국 정부에서 IMO 협약 및 규정에 대한 이행은 필수적이다. IMO 협약이행코 드(III Code)에서는 각 주관청에게 협약이행을 주기적으로 점검 및 평가하여 개선하는 체계를 갖추도록 요구하고 있으며 성과지표를 평가방 법에 포함하도록 요구하고 있음에 따라 회원국은 자국의 협약이행 평가를 위한 성과지표를 개발할 필요가 있다. 이에, 본 논문의 목적은 주관청의 협약이행 수준을 계량화하여 평가할 수 있도록 대표적인 평가측정 기법인 균형성과표(BSC) 및 핵심성과지표(KPI)를 활용한 평가 모델을 개발하여 제시하는 것이다. 논문의 결과로서, III Code 요건에 BSC 개념을 적용한 III-BSC 관점에서 수립된 비전의 달성을 위해 반드 시 확보해야 하는 핵심성공요인(CSF)을 도출하고, 도출된 CSF를 측정할 수 있도록 평가영역별 후보 KPI를 개발하여 4계층의 초기 연구모형 을 설계하였으며, SMART 기법을 활용한 조사설계를 통해 KPI의 타당성을 검증하여 연구모형을 완성하였다. 또한, 개발한 연구모형을 기반 으로 AHP 분석을 통해 각 계층별 요소의 가중치를 도출하여 BSC 기반 IMO 협약이행에 대한 평가모델을 개발하여 제시하였다. 개발된 평 가모델이 정량적으로 IMO 협약이행 수준을 파악하는 도구로 활용될 수 있으며, 이를 통해 IMO 회원국들의 협약이행 수준 개선에 기여할 수 있을 것으로 기대한다.

This thesis relates to developing an index drilling automation system that quickly and efficiently processes a hole in a product by a rotating robot arm and transfer devices. Static structural analysis was performed using the ANSYS Mechanical program to evaluate the structural stability of the system. According to the research, the equivalent stress value is low overall, and the minimum safety factor is 4.42, so it seems structurally safe. This system will significantly help improve productivity through unmanned work as it can control and set the drill and index simultaneously on the control panel in conjunction with the training.

자율운항선박이 상용화되어 연안을 항해하기 위해서는 해상의 장애물을 탐지할 수 있어야 한다. 연안에서 가장 많이 볼 수 있 는 장애물 중의 하나는 양식장의 부표이다. 이에 본 연구에서는 YOLO 알고리즘을 이용하여 해상의 부표를 탐지하고, 카메라 영상의 기하 학적 해석을 통해 선박으로부터 떨어진 부표의 거리와 방위를 계산하여 장애물을 시각화하는 해상물체탐지시스템을 개발하였다. 1,224장 의 양식장 부표 사진으로 해양물체탐지모델을 훈련시킨 결과, 모델의 Precision은 89.0 %, Recall은 95.0 % 그리고 F1-score는 92.0 %이었다. 얻 어진 영상좌표를 이용하여 카메라로부터 떨어진 물체의 거리와 방위를 계산하기 위해 카메라 캘리브레이션을 실시하고 해상물체탐지시 스템의 성능을 검증하기 위해 Experiment A, B를 설계하였다. 해상물체탐지시스템의 성능을 검증한 결과 해상물체탐지시스템이 레이더보 다 근거리 탐지 능력이 뛰어나서 레이더와 더불어 항행보조장비로 사용이 가능할 것으로 판단된다.

EPS(Electric Power Steeing) has been a popular system in the automotive industry since 2000 after the technology and safety was validated. The Korean Refrigerated Carts like Hankook Yogurt Coco was developed for the first time in the world. However this carts system and other small tranporting carts has no EPS. Thus the drivers of carts needed a EPS to avoid the burden when steeing a big weighted cart with 750Kgf as many women drivers complain the pain on their shoulders. This paper describes the application of EPS on Korean refrigerated carts with simulation results and experimental data shows the improvement of steering efforts.

This study described a way of developing a resin for deviceizing quantum dots. Furthermore, the following conclusions were obtained by developing light curable syrup and UV curable syrup. First, The viscosity of the mixed resin decreased as the content of the diluent increased, and the value was bewteen 4,310 and 1,473cps. Second, haze was measured by using NDH 5000, and all of the synthesized syrups were obtained a haze value of 1% or less with a transmittance of 95% or more in the visible light region. Third, the viscosity of the mixed resin decreased as the temperature increased, and at this point, the viscosity showed a value of 4,219 to 1,128cps. Lastly, As a result of measuring the viscosity of the resin before and after mixing the quantum dot nanoparticles, it appears to be little change.

Bellows product is an important part in the area of plant engineering, shipbuilding and petrochemistry. For safety and durability it is necessary to consider lots of factors when designing it. This research developed a metal bellows design software based on EJMA 10th Edition manual. This Bellows software was developed by using Excel software and can be able to design U type of bellows which are Unreinforced Single Bellows, Unreinforced Double Bellows, Reinforced Single Bellows and Reinforced Double Bellows. The already proven bellows model were designed to verify this software. This software would predict the life cycle of a product and produce a company report to be provided to the demanding company. This suggested updated software will be helpful for design engineers to save time and effort.

본 연구는 급속하게 성장하는 시설농업과 동시에 증가하는 에너지 사용량 및 탄소배출량을 저감하기 위해, 온실의 에너 지 부하를 동적으로 분석하기 위한 작물에너지의 다중 회귀 모델 개발을 수행하였다. 온실은 연중 안정적인 대량 생산을 위한 적절한 환경을 조성하기 위해 에너지 투입이 필요하다. 도시농업의 일종인 옥상온실 플랫폼을 통해 건물에서 버려지 거나 활용되지 않는 에너지를 옥상온실에서 사용할 수 있다. 옥상온실의 효율적인 운영을 위해서는 다양한 환경 조건에 대 한 동적 에너지 분석이 선행되어야 하며, 온실에 도입되는 태 양 에너지의 40－75%가 작물을 위한 에너지 교환이므로 필수적으로 고려되어야 한다. 한국기계연구원 내 옥상온실에서 여름철에 청경채를 재배하며 생장단계에 따른 에너지 교환을 분석하였다. 작물을 중심으로 미기상 및 양액 환경 분석과 생 장 특성 조사를 수행하였다. 정식일수에 따른 엽면적지수를 추정하였으며, 개발된 수식은 결정계수 0.99로 분석되었다. 또한 작물에너지 흐름에 지배적인 잎 표면온도로부터의 현열 부하와 증발산에 의한 잠열부하로 나누어 모델을 개발하였다. 엽온과 증발산량을 각각 다중 회귀모델을 이용하여 추정하고 실측한 값을 비교해 보았을 때, 평균 결정계수 0.95, 0.71로 분 석되었으며, 이 모델을 이용하여 옥상온실의 에너지 부하를 동적으로 산정하기 위한 모델에 입력값으로 사용할 수 있을 것으로 판단된다.

The South Korea government has set a development goal of attracting 200,000 students from around the world to study in Korea by 2023. As the main exporter of Korean students, the number of Chinese students in Korea has been declining year by year. According to the official data released by the Ministry of Education of South Korea, this paper focuses on the analysis and evaluation of Chinese international students in school and regional selection, education level and distribution of disciplines and majors, and the development trend of the number of students. Based on the push-pull theory, the pull factor of studying in Korea and the push factor of China are summarized. The purpose of the study is to put forward practical countermeasures and suggestions on the development of Chinese students in South Korea, in order to reverse the current downward trend of the number of Chinese students in South Korea. The results show that the quality of cultivation can be improved through scientific policy making. We should balance educational advantages, rationally allocate resources, optimize professional structure, and expand the scale of overseas study. Strengthen the publicity of studying abroad and shape the ecology of studying abroad. The number of Chinese students in Korea is expected to increase.