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        검색결과 79

        61.
        2019.03 KCI 등재 서비스 종료(열람 제한)
        본 연구는 번 슈미트의 전략적 체험 모듈을 기반으로 한 챗봇 마케팅이 브랜드 강화와 서비스 운영에 어떻게 적용되고 있는 지에 대하여 서비스 분야를 중심으로 구체적인 활용 사례를 살펴보고 국내 챗봇의 CUI(대화형 사용자 인턴페이스)가 제공하 는 체험 기반 서비스 운영 사례 분석을 통해 챗봇을 도입, 활용하고자 하는 브랜드 및 유관 기관의 효과적인 서비스 강화를 목적으로 하고 있다. 이에 따라 국내 챗봇의 CUI가 제공하는 체험 유형을 분류하고, 각 체험 유형들이 서비스 운영에 어떠한 방식으로 적용되고 있는지 분석하고자 하였으며, 이를 위해 평판이 높은 브랜드의 챗봇에서 나타나는 감각, 감성, 인지, 행동, 관계의 다섯 가지 체험요소를 분석하였다. Robert K. Yin의 질적연구방법을 근거로 5단계의 사례분석을 진행하였으며 Bernd Schmitt의 체험 마케팅 이론을 토대로 분석 모델을 설계, 챗봇 사례와 CUI 환경의 이용방법에 따른 특징을 파악하여 전략적 모듈별 체험을 통해 향 후 챗봇 CUI 환경의 체험적 연구와 총체적 체험에 대한 이해 및 활용 방안을 제시하고자 하였다. 연구결과, 금융 분야의 경우 인지와 행동 체험 효과가 높고 감각과 감성 체험이 전체적으로 낮게 나타난 반면, 유통 분야에 있어서는 다섯 가지 체험 요소가 모두 높게 나타나는 특징을 보였다. 의료 분야의 경우 관계 체험을 제외한 나머지 요소들이 타 분야에 비해 낮게 나타나고 있는데 이는 의료 분야의 구조적 특수성이 반영된 것으로 서비스 완성도를 위한 노력이 상대적으로 높게 요구되고 있다는 것을 의미한다. 또한 법률 정보의 접근과 해석, 결론 도출의 특수성을 가진 법률 분야의 경우, 인지 체험 효과가 높고 상대적으로 감성 체험이 낮은 것으로 나타났으며, 사용자의 감성과 행동에 기능의 초점 을 맞추고 있는 엔터테인먼트 분야의 경우 관계에 이를수록 모든 체험 요소의 효과가 높게 나타나는 것으로 분석되었다. 이와 같이 분야의 특수성이나 운영 중인 CUI의 완성도에 따라 각 요소의 체험도가 다르게 나타나고 있으나 챗봇 운영을 통한 소비자와의 커뮤니케이션 실효성을 보다 향상시키기 위해서는 체험 마케팅의 다섯 가지 요소를 포괄적으로 활용하여 소비자들에게 총체적 체험 제공이 가능한 서비스를 개발하는 것이 중요할 것이며, 본 사례 연구가 다양한 챗봇 마케팅의 확장을 통한 브랜드 서비스 강화에 있어 효율적 방안 마련의 시사점과 기초를 제공해 줄 것으로 기대한다.
        62.
        2018.10 서비스 종료(열람 제한)
        In this study, the development of gravity type collecting device for nuclear dismantling through CFD simulation is shown as follows. As a result of investigating the dust removal efficiency according to the treatment air velocity of 5 m/s (low speed) ~ 30 m/s (high speed), large dusts (80 ~ 100 ㎛) As the wind speed increases, the damping efficiency decreases and the particle size of the dust behavior increases with the increase of the wind speed. As a result, the wind speed (wind speed) 5 m/s is considered to be suitable for improving the vibration damping efficiency.
        63.
        2017.05 서비스 종료(열람 제한)
        Background : Methicillin-Resistant Staphylococcus aureus (MRSA) is a multidrug-resistant (MDR) strain. Especially, MRSA is developing resistance to available antibacterial agents and causing complications in the treatment of infections related to skin, soft tissue, respiratory, bone, joint, and endovascular disorders. Therefore, antibacterial agent combination therapy appears to be a useful option, particularly in developing countries where antibiotic availability is limited. (+)-Usnic acid (UA) is uniquely found in lichens, and is especially abundant in genera such as Usnea and Cladonia. UA has antimicrobial activity against human and plant pathogens. Therefore, UA may be a good antibacterial drug candidate for clinical development. Methods and Results : In search of a natural products capable of inhibiting this multidrug-resistant bacteria, we have investigated the antimicrobial activity of UA against MRSA. In this study, the effects of a combination of UA and permeable agents against MRSA were investigated. For the measurement of cell wall permeability, UA with concentration of Ethylenediaminetetraacetic acid (EDTA) was used. In the other hand, Sodium azide (NaN3) was used as inhibitors of ATPase. These results suggest that the antibacterial effect of UA was potentiated by membrane-binding agents and ABC transporter-inhibiting agents, implying that antibacterial activity is associated with damage of the cell wall and inhibition of ATPase function by UA. Conclusion : UA and in combination with EDTA and NaN3 could lead to the development of new combination antibiotics against MRSA infection. The results of this study appear to be promising, and they are expected to enhance the use of natural products as drugs.
        64.
        2016.12 KCI 등재 서비스 종료(열람 제한)
        Fas ligand (FasL) and its receptor Fas have been implicated in granulosa cell apoptosis during follicular atresia. Although interferon-gamma (IFN-γ) is believed to be involved in the regulation Fas expression in differentiated granulosa or granulosa-luteal cells, the expression of this cytokine and its role in the regulation of the granulosa cell Fas/FasL system and apoptosis during follicular maturation have not been thoroughly investigated. In the present study, we have examined the presence of IFN-γ in ovarian follicles at different stage of development by immunohistochemistry and related their relative intensities with follicular expression of Fas and FasL, and with differences in granulosa cell sensitivity to Fas activation by exogenous agonistic Anti-Fas monoclonal antibody (Fas mAb). Although IFN-γ immunostaining was detectable in oocyte and granulosa cells in antral follicles, most intense immunoreactivity for the cytokine was observed in these cells of preantral follicles. Intense immunoreactivity for IFN-γ was most evident in granulosa cells of atretic early antral follicles where increased Fas and FasL expression and apoptosis were also observed. Whereas low concentrations of IFN-γ (10-100 U/mL) significantly increased Fas expression in undifferentiated granulosa cells (from preantral or very early antral follicles) in vitro, very higher concentrations (≥ 1,000 U/mL) were required to up-regulate of Fas in differentiated cells isolated from eCGprimed (antral) follicles. Addition of agonistic Fas mAb to cultures of granulosa cells at the two stages of differentiation and pretreated with IFN-γ (100 U/mL) elicited morphological and biochemical apoptotic features which were more prominent in cells not previously exposed to the gonadotropin in vivo. These findings suggested that IFN-γ is an important physiologic intra-ovarian regulator of follicular atresia and plays a pivotal role in regulation of expression of Fas receptor and subsequent apoptotic response in undifferentiated (or poorly differentiated) granulosa cells at an early (penultimate) stage of follicular development.
        65.
        2016.10 서비스 종료(열람 제한)
        Background : Ginseng, one of most famous traditional oriental medicines, has been known for a number of pharmacological properties including anti-tumor, anti-diabetic, anti-fatigue, anti-stress, anti-oxidative, and anti-aging effects. 20(S)-Protopanaxadiol (PPD), a intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. In this study, we investigated the synergistic anticancer effect of 20(S)-PPD and temozolomide (TMZ) and the mechanism of 20(S)-PPD on glioblastoma cells. Methods and Results : We examined cell viability and the morphological changes of C6 cells after treatment of 20(S)-PPD and TMZ. 20(S)-PPD showed a potent antiproliferative activity against C6 cells by triggering apoptosis. 20(S)-PPD-induced apoptosis was characterized by a dose-dependent mitochondrial damage. 20(S)-PPD and TMZ had a synergistic effect in increasing mitochondrial damage via caspase 3 activation. Conclusion : These results revealed an unexpected mechanism of 20(S)-PPD and TMZ, triggering a mitochondrial-mediated apoptosis in C6 cells. Our findings encourage further studies of 20(S)-PPD as a promising chemopreventive agent against glioblastoma.
        66.
        2016.10 서비스 종료(열람 제한)
        Background : Recently, ginseng (Panax ginseng C.A. Meyer.) berry has been used as a health-promoting supplements. Also, Mulberries (Morus alba L.) fruit have been used in traditional herbal medicine to treat and prevent diabetes. In this study, we measured the cytotoxicity after fermentation of the extracts in Panax Ginseng Berry and Mulberry Fruit. Methods and Results : The extracts were prepared by decoction for 3 hours in distilled water (100 g/L). The dried extract was then dissolved in phosphate-buffered saline (PBS) in preparation for use. Cell viability was examined by an MTT assay. RAW 264.7 cells were seeded at 1 × 104/mL densities in 96-well plates. Each grouping had a non-treated group as the control. The extracts were added to each well and incubated for 24 hours at 37°C and 5% CO2. The MTT solutions (5 mg/mL) were added to each well, and the cells were cultured for another 2 hours. The supernatant was then discarded, and 100 μL of dimethyl sulfoxide was added to each well. The optical density was read at 540 nm. Conclusion : Probiotics and prebiotics modulate the composition of human and domestic animal gut microbiota. The beneficial effects may result from suppression of harmful microorganisms or stimulation of organisms which contribute in a positive way to the nutrition and health of human and domestic animal. Recently, fermentation using microorganisms for the production of more effective compounds has been extensively studied. In particular, the novel pharmacological effects of a new compound generated by fermentation have been reported. Some previous studies have demonstrated that Fermented herbal medicine extract showed better bioactivity than normal herbal Plants extract when used at the same concentration.
        67.
        2016.09 KCI 등재 SCOPUS 서비스 종료(열람 제한)
        We present proton-induced single event effects (SEEs) and γ-ray-induced total ionizing dose (TID) data for 1 Gbit lowpower double data rate synchronous dynamic random access memory (LPDDR SDRAM) fabricated on a 5 μm epitaxial layer (54 nm complementary metal-oxide-semiconductor (CMOS) technology). We compare our radiation tolerance data for LPDDR SDRAM with those of general DDR SDRAM. The data confirms that our devices under test (DUTs) are potential candidates for space flight applications.
        68.
        2013.12 KCI 등재 서비스 종료(열람 제한)
        FGF9/16/20 signaling pathway specify the developmental fates of notochord, mesenchyme, and neural cells in ascidian embryos. Although a conserved Ras/MEK/Erk/Ets pathway is known to be involved in this signaling, the detailed mechanisms of regulation of FGF signaling pathway have remained largely elusive. In this study, we have isolated Hr-Erf, an ascidian orthologue of vertebrate Erf, to elucidate interactions of transcription factors involved in FGF signaling of the ascidian embryo. The Hr-Erf cDNA encompassed 3110 nucleotides including sequence encoded a predicted polypeptide of 760 amino acids. The polypeptide had the Ets DNA-binding domain in its N-terminal region. In adult animals, Hr-Erf mRNA was predominantly detected in muscle, and at lower levels in ganglion, gills, gonad, hepatopancreas, and stomach by quantitative real-time PCR (QPCR) method. During embryogenesis, Hr-Erf mRNA was detected from eggs to early developmental stage embryos, whereas the transcript levels were decreased after neurula stage. Similar to the QPCR results, maternal transcripts of Hr-Erf was detected in the fertilized eggs by whole-mount in situ hybridization. Maternal mRNA of Hr-Erf was gradually lost from the neurula stage. Zygotic expression of Hr-Erf started in most blastomeres at the 8-cell stage. At gastrula stage, Hr-Erf was specifically expressed in the precursor cells of brain and mesenchyme. When MEK inhibitor was treated, embryos resulted in loss of Hr-Erf expression in mesenchyme cells, and in excess of Hr-Erf in a-line neural cells. These results suggest that zygotic Hr-Erf products are involved in specification of mesenchyme and neural cells.
        71.
        2007.12 KCI 등재 서비스 종료(열람 제한)
        "Chuyoung" as a new double cropping potato variety was bred in 2005 for table use through a cross between "Dejima" with short tuber dormancy and HRB-31 which is a tetraploid derived from an interspecific cross between "Russet Burbank" and Solanum phureja line. It was evaluated for short dormancy, growth and tuber characteristics every twice a year from 1997 to 2001. Regional yield trials were performed from 2002 to 2004 at three locations, Jeju, Namhae and Gangneung of Korea, respectively. Its tuber shape is oblong with yellow skin and flesh colors. Its dormant periods is 60~70days. It showed less incidence of physiological disorders such as cracking or knobs on tubers, and higher resistance to common scab by Streptomyces scabies compared to "Dejima". It has tall plant height and erect growth type with green-broad leaflets and white large inflorescence. Its average yields are 29.5 and 22.6 ton/ha at 90 days after planting in spring and autumn cropping, respectively. It also showed higher marketable yield due to the lower incidence of common scab and physiological disorders compared to "Dejima".
        76.
        2004.06 KCI 등재 서비스 종료(열람 제한)
        Gahwang is an excellent chipping cultivar with yellow flesh, short oval tuber shape and mid-early maturity. Its yields were a little higher than Atlantic through the regional trials with five locations. It has a lower incidence of internal brown spot comp
        77.
        2004.06 KCI 등재 서비스 종료(열람 제한)
        Shinnamjag is a round, smooth, white-skinned, and fleshed potato cultivar with erect plant shape and early maturity. It has excellent table quality. Its yields are high, especially with prominent marketable yield compared to Superior, a leading potato cul
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