본 논문은 중국 고대 우주론(宇宙論, cosmology)적 사유를 디지털인문학 (Digital Humanities)적 방법을 통해 비교, 분석하는 것을 목적으로 한다. 본 연 구는 철학과 사상을 대상으로 한 디지털인문학적 연구는 ‘대규모 데이터(big data)’를 이용한 연구보다는 오히려 특정 텍스트 안의 한정된 ‘소규모 데이터 (small data)’를 분류, 재구성, 시각화하고 분석함으로써 더 유의미한 결과를 얻 을 수 있다는 입장에서 시도되었다. 본 연구는 ｢태일생수｣에 대한 기존의 연구를 정리, 분석하여 디지털인문학 적 방법을 통해 기존의 연구를 보완할 지점을 도출하였다. 중국 최초의 우주론 적 텍스트 중 하나인 ｢태일생수(太一生水)｣와 중국 우주론에서 가장 중요한 위 치를 점하고 있는 ｢태극도설(太極圖說)｣을 중심으로 중국 고대 우주론의 텍스 트들을 디지털인문학적 방법을 통해 데이터화하고 구조화하여 비교함으로써 중국 고대 우주론의 연속성과 발전의 양상을 분석하였다. 본 연구는 ｢태일생수 ｣가 시간과 공간에서의 생성(generation)을 묘사하는 우주생성론(cosmogony)이지 만 우주의 공시적(共時的, synchronic) 구조를 관조하는 형이상학(metaphysics) 혹 은 존재론(ontology)의 단초 역시 가지고 있었고 후대 성리학의 ｢태극도설｣은 형이상학/존재론적 우주론이 극단적으로 강조된 모델임을 논한다.

Background : This study aimed to identify the mechanisms of the antinociceptive effects of PG in the fibromyalgia (FM)-like animal model. Methods and Results : To assess the possible effect of PG on FM symptoms, we constructed a FM animal model induced by intermittent cold stress with slight modification. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relation between PG and the expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated CREB (p-CREB), western blotting and immunohistochemistry analyses were performed. In behavioral analysis, nociception tests showed that the pain threshold was significantly decreased in the FM group compared to control group. Western blot and immunohistochemical analyses of the medial prefrontal cortex and hippocampus showed downregulation of BDNF and p-CREB proteins in the FM group compared to control group. PG recovered these changes at behavioral tests and protein level. These results provide evidence that the effects of PG extract in the FM model may be related to its modulating effect on the BDNF signaling pathway in the hippocampus and medial prefrontal cortex. Conclusion : Our animal model may be involved in the mechanism by which PG extract is effective as a therapeutic agent for FM.

Background: Prenatal exposure to infectious and/or inflammatory insults can increase the risk of developing neuropsychiatric disorder such as bipolar disorder, autism, and schizophrenia later in life. We investigated whether Valeriana fauriei (VF) treatment alleviates prepulse inhibition (PPI) deficits and social interaction impairment induced by maternal immune activation (MIA).Methods and Results: Pregnant mice were exposed to polyriboinosinic-polyribocytidilic acid (5㎎/㎏, viral infection mimic) on gestational day 9. The adolescent offspring received daily oral treatment with VF (100㎎/㎏) and injections of clozapine (5㎎/㎏) for 30 days starting on the postnatal day 35. The effects of VF extract treatment on behavioral activity impairment and protein expression were investigated using the PPI analysis, forced swim test (FST), open field test (OFT), social interaction test (SIT), and immunohistochemistry. The MIA-induced offspring showed deficits in the PPI, FST, OFT, and SIT compared to their non MIAinduced counterparts. Treatment with the VF extract significantly recovered the sensorimotor gating deficits and partially recovered the aggressive behavior observed in the SIT. The VF extract also reversed the downregulation of protein expression induced by MIA in the medial prefrontal cortex.Conclusions: Our results provide initial evidence of the fact that the VF extract could reverse MIA-induced behavioral impairment and prevent neurodevelopmental disorders such as schizophrenia.