본 논문은 지각된 가치가 적용된 관광 행동의도 정보를 이용한 지능형 클라우드 환경에서의 관광추천시스템을 제안한다. 이 제안 시스템은 관광정보와 관광객의 지각적 가치가 행동의도에 반영되는 실증적 분석 정보를 와이드 앤 딥러닝 기술을 이용하여 관광추천시스템에 적용하였다. 본 제안 시스템은 다양하게 수집할 수 있는 관광 정보와 관광객이 평소에 지각하고 있던 가치와 사람의 행동에서 나타나는 의도를 수집 분석하여 관광 추천시스템에 적용하였다. 이는 기존에 활용되던 다양한 분야의 관광플랫 폼에 관광 정보, 지각된 가치 및 행동의도에 대한 연관성을 분석하고 매핑하여, 실증적 정보를 제공한다. 그리고 관광정보와 관광객의 지각적 가치가 행동의도에 반영되는 실증적 분석 정보를 선형 모형 구성요소와 신경만 구성요소를 합께 학습하여 한 모형에서 암기 및 일반화 모두를 달성할 수 있는 와이드 앤 딥러닝 기술을 이용한 관광추천 시스템을 제시하였고, 파이프라인 동작 방법을 제시하였다. 본 논문에서 제시한 추천시스템은 와이드 앤 딥러닝 모형을 적용한 결과 관광관련 앱 스토어 방문 페이지 상의 앱 가입률이 대조군 대비 3.9% 향상했고, 다른 1% 그룹에 변수는 동일하고 신경망 구조의 깊은 쪽만 사용한 모형을 적용하여 결과 와이드 앤 딥러닝 모형은 깊은 쪽만 사용한 모형 대비해서 가입률을 1% 증가하였다. 또한, 데이터셋에 대해 수신자 조작 특성 곡선 아래 면적(AUC)을 측정하여, 오프라인 AUC 또한 와이드 앤 딥러닝 모형이 다소 높지만 온라인 트래픽에서 영향력이 더 강하다는 것을 도출하였다.

Big data analysis in healthcare research seems to be a necessary strategy for the convergence of sports science and technology in the era of the Fourth Industrial Revolution. The purpose of this study is to provide the basic review to secure the diversity of big data and healthcare convergence by discussing the concept, analysis method, and application examples of big data and by exploring the application. Text mining, data mining, opinion mining, process mining, cluster analysis, and social network analysis is currently used. Identifying high-risk factor for a certain condition, determining specific health determinants for diseases, monitoring bio signals, predicting diseases, providing training and treatments, and analyzing healthcare measurements would be possible via big data analysis. As a further work, the big data characteristics provide very appropriate basis to use promising software platforms for development of applications that can handle big data in healthcare and even more in sports science.

chemosensitivity test of Geungsonojukwhan-Bijukbang was performed on the three different human cancer cell lines originated from liver, cervix and colon tissue, namely Hep 3B, Hela and HCT-15, which have similar doubling times. Semiautomated sulforhodamine B(SRB) assay appears to offer an valuable tool for chemosensitivity of unknown compounds, since it is a simple, valid and inexpensive method of assessing drug monitoring for large samples in a short time. The results obtained in this study were as follows 1. Good correlations were shown from the results of SRB assay and those of clogenetic assay. 2. As a result of exposure to Geungsonojukwhan, the proliferation of Hela cell and Hep 3B cell was slightly decreased in Geungsonojukwhan-Bijukbang(GIP), Geungsonojukwhan-Pejukbang(LUP) and Geungsonojukwhan-Sinjukbang(RTP). 3. As a result of exposure to Geungsonojukwhan, GIP showed better anticancer effect to HCT-15 cell lines than those of LUP and RTP. 4. The extract of Geungsonojukwhan-Bijukbang in 40℃ were more effective in cytotoxic response than those in 100℃. 5. The research showed that the higher concentration the more effective in the inhibition of proliferation of the cancer cell lines, however, the cytotoxic effect of Geungsonojukwhan-Bijukbang in the concentration of 1.60㎎/㎖ and 3.20㎎/㎖ showed the most effective inhibition rate according to the increase of concentration.

Nitric oxide(NO) is synthesized via the oxidation of L-arginine by a family of nitric oxide synthases(NOS), which are either constitutive(cNOS) or inducible(iNOS). The induction of iNOS in tissues can lead to the sustained production of high concentrations of NO which may exert pro-inflammatory effects including vasodilation, edema, cyototoxicity, and its activity can be mediated by various pro-inflammatory cytokine, including interferonγ(INF- γ), tumor necrosis factor, IL-1 and IL-6. The enzyme, iNOS, became a new target for pharmacologcal research with the aim to find new substances for the treatment of chronic inflammatory disorders. Murine macrophages produce large amounts of NO when activated with TFN-γ plus LPS. Murine macrophage-like cell line, RAW 264.7, is a suitable cell model to perform in vitro studies regarding the iNOS system. Artemisin feddei Lev. et Vnt.(Compositae) is a perennial herb growing in Korea. The aerial parts have been used in foik medicine as antiinflammatory, antipyretic, choleretic and diuretic agent. Sesquiterpenelactones were isolated from this plant. In the course of screening for NO inhibitory activity from medicnial plants, the aqueous extract of this plant was found to have a significant activity.

Anal Therapy is another way of taking medicine. It is a traditional pathway but not available in common situation. Nevertheless, It has many benifect and usefulness, it has not treated so much. As there are many kinds of Anal therapy, this study use retention type. Sochungyongtang (SCYT) has been known to be the most effective prescription largely applied to bronchial asthma, whooping cough, pneumonia, pleurisy, nephritis and arthritis and so forth. In this study, the author investigated the effect of an aqueous extract of SCYT by Anal therapy (Retention Enema) in immediate type allergic reaction. The following results were obtained 1. Retention Enema of SCYT showed a marked inhibition rate in systemic immediate-type allergic reaction with a dose of 1000 mg/kg 1 hr before intraperitoneal injection of compound 48/80. 2. SCYT significantly reduced serum histamine contents induced by compound 48/80. SCYT (1000 mg/kg) also inhibited to 64.11±19.86% (P<0.01) local immediate-type allergic reaction activated by anti-dinitrophenyl (DNP) IgE. 3. In addition, SCYT dose-dependently inhibited the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. These results provide evidence that anal therapy (Retention enema) of SCYT may be beneficial in the treatment of systemic and local immediate-type allergic reaction.