In a series of recent launch tests, North Korea has been improving the firepower of its missiles that can target South Korea. North Korea’s missiles and submarines are capable of threatening targets in South Korea and are likely faster and more covert than the systems previously seen in North Korea. The advanced threats require that ROK Navy should not only detect them earlier than ever but also response quicker than ever. In addition to increasing threats, the number of young man that can be enlisted for military service has been dramatically decreasing. To deal with these difficulty, ROK navy has been making various efforts to acquire a SMART warship having enhanced defense capability with fewer human resources. For quick response time with fewer operators, ROK Navy should improve the efficiency of systems and control tower mounted on the ship by promoting the Ship System Integration. Total Ship Computing Environment (TSCE) is a method of providing single computing environment for all ship systems. Though several years have passed since the first proposal of TSCE, limited information has been provided and domestic research on the TSCE is still in its infancy. In this paper, we apply TSCE with open architecture (OA) to solve the problems that ROK Navy is facing in order to meet the requirements for the SMART ship. We first review the level of Ship System Integration of both domestic and foreign ships. Then, based on analyses of integration demands for SMART warship, we apply real time OA to design architecture for TSCE from functional view and physical view. Simulation result shows that the proposed architecture has faster response time than the response time of the existing architecture and satisfies its design requirements.

In this study was analyzed substances that high contribute to odor strength degree which emitted from the painting, the plating, the casting, the rubber manufacturing, and the used oil refining facilities in Gwangju Hanam industrial complex. In order to this, we analyzed two types of nitrogen compounds, five types of sulfur compounds, thirteen types of the aldehyde, and ten types of volatile organic compounds discharged from an outlet for antipollution facilities. The results are as following high contribution rate sustances to odor strenth was ordered butylaldehyde (73.8%) ＞ acetaldehyde (17.7%) ＞ propionaldehyde (4.9%) at painting facilities. At plating facilities, it was ordered Acetaldehyde (59.0%) ＞ ammonia (19.1) ＞ hydrogen sulfide (13.1%). At casting facilities, it was ordered Hydrogen sulfide (65.9%) ＞ acetaldehyde (17.2%) ＞ sulfur dioxide(5.2%). At rubber manufacturing facilities, it was ordered i-valeraldehyde (35.0%) ＞ butylaldehyde (32.0%) ＞ n-valeraldehyde (13.3%) and at used oil refinery facilities, it was ordered Acetaldehyde (36.8%)＞ butylaldehyde (33.6%) ＞ sulfur dioxide (14.5%).

본 연구의 목적은 토종다래의 용매별 추출물에 따른 약리활성에 대한 검증 및 효능 평가로서 토종다래의 항산화, 항염증에 대한 효과를 확인하였다. 염증 반응은 자극이 가해지면 histamine, serotonin, prostaglandin과 같은 혈관 활성물질에 의해 혈관 투과성이 증대되어 염증을 유발하고 cytokine, free radical, lysosomal enzyme 등 다양한 매개 인자가 관여한다. 자극에 의한 macrophage cell의 염증반응은 tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-1β(IL-1β)와 같은 pro-inflammatory cytokine의 발현이 유도되고, inducible nitric oxide synthase(i-NOS)와cyclooxygenase-2(COX-2)에 영향을 받는 유전자의 발현을 자극하게 되어 nitric oxide(NO) 등의 염증 인자가 생성된다. 이에 따라 토종다래 추출물의 항염증에 대한 연구를 위해 이에 영향을 주는 인자인 i-NOS, COX-2의 단백질 발현억제 작용을 확인하였다. 그 결과, HKE > HKA > HKW 순서로 높은 효능을 확인 할 수 있었다. 가장 효과가 좋은 HKE 처리군에서 다양한 염증성 인자의 mRNA 발현량을 확인하였다. 측정 결과, HKE(2,000 μg/mL)는 i–NOS, COX-2, IL-1β, IL-6, TNF-α mRNA 발현이 각각 93.2%, 27.9%, 96.4%, 89.4%, 73.9% 억제되는 효과를 확인할 수 있었다. 또한, HKE의 nuclear factor kappa B(NF-κB) 단백질 발현에 농도의존적으로 유의미한 결과를 확인하였으며, 이에 토종다래의 항염증효과는 LPS에 의한 TLR4의 자극에서 NF-κB 경로의 완화로 나타는 것임을 검증하였다. 결론적으로 토종다래는 70% ethanol 추출물(HKE)의 항염증 효과가 가장 높았으며, HKE는 대식세포에서 NF-κB 염증관련 경로의 억제로 세포 내 mRNA 및 단백질 수준에서의 염증인자들의 생성을 저해하여 항염증 효과가 명백히 확인되었다. 향후 본 연구팀은 토종다래의 항염증과 관련된 유효성분의 분리정제 및 구조분석을 진행할 예정이다.

Prunus sargentii of Rosaceae familiy, has been reported to have radical scavenging activity and anti-inflammatory effect. On these facts, this research was conducted to evaluate pharmaceutical activities of the bark extracts P. sargentii. Free radical scavenging activities of fraction (Fr) -5~10 isolated from P. sargentii was higher than 80% respectively at 10ppm. The superoxide dismutase (SOD)-like activity of Fr-5, 9 were about 97, 84%, respectively at 1,000 ppm. Xanthine oxidase inhibitory effect of Fr-9, 10 were about 75, 78%, respectively at 1,000 ppm. The tyrosinase inhibitory effect related to skin-whitening was 72, 68% in Fr-2, 9 isolated from Prunus sargentii R. at 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 98% for Fr-8 at 500 ppm. Isolation of the methanol soluble fraction from P. sargentii yielded two major phenol compounds, (-)-epicatechin and taxifolin. The structure of the compound was certainly determined by chemical analyses, as well as NMR and Mass spectroscopy. The present study was carried out in a search for new cosmetic material from the bark from P. sargentii. and, (-)-epicatechin and taxifolin were isolated as active principles. So P. sargentii R. methanolic extracts may be used for the cosmetic material.