The objective of this study was to produce a nutrient delivery system (NDS) using sialic acid extracted from edible bird’s nest (EBN), which improves brain function in patients with Alzheimer’s disease and Parkinson’s disease, by affinity bead technology (ABT). The inhibitory activity of acetylcholinesterase (AChE) and pyramidal cells in the dentate gyrus of the hippocampus were analyzed to investigate the effect of a sialic acid NDS on Alzheimer’s disease. Also, the effect of a sialic acid NDS on Parkinson’s disease was evaluated by rota-rod test and pole test in an animal model. Among the groups treated with donepezil, EBN, and sialic acid NDS, the AChE activity was the lowest in the sialic acid NDS-treated group. The results of the hippocampus analysis of the rat model confirmed that the sialic acid NDS inhibited amyloid-beta accumulation depending upon the concentration. Also, the sialic acid NDS group showed more improvement in motor deterioration than the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced group in both the rota-rod test and pole test. Therefore, the sialic acid NDS had an effect of protecting not only Alzheimer’s disease by inhibiting AChE and amyloid-beta accumulation, but Parkinson’s disease by preventing neurotoxicity induced by MPTP.

아산만 인근해역은 최근 20여년 넘게 실시된 각종 방조제 공사가 저서동물의 군집구조에 영향을 주는 것으로 알려지고 있지만, 이에 대한 연구는 충분치 않다. 그러므로 본 연구에서는 화옹방조제 건설 이후 아산만 대형저서동물의 군집구조에 영향을 주는 환경요인을 분석하였다. 대형저서동물 채집은 2007년 8월과 2008년 2월에 아산만 주변 해역 22개의 정점에서, 스미스 맥킨타이어 그랩(Smith McIntyre Grab, 표면 면적: 0.1m2)을 이