동물의 종 유지에 있어서 교미행동은 매우 중요한 위치를 차지함. 교미과정에서 수컷의 경우 모든 암컷에 대해 성행동을 보이는반면, 암컷은 가장 적절한 교미의 시기를 정하며, 적절한 수컷을 선택하고 교미행동을 보이기 때문에 암컷의 교미행동을 유도하는 과정은 생물학에서 매우 중요한 의미를 지님. 본 연구에서는 초파리 (Drosophila melanogaster) 전자현미경자료와 총신경망분석 (Connectomics)을 이용하여 초파리 뇌에서 암컷의 교미행동을 조절하는 것으로 알려진 pC1신경의 하부신경 pC1b,c가 성적 성숙과정에서 교미를 하고자 하는 욕구 (sexual drive)를 증가시키는 기능을 하는 것을 처음으로 밝힘. 본 연구에서는 처음으로 pC1b,c 신경 내의 cAMP 수준이 교미의 욕구변화를 보여주는 중요한 물질이라는 것을 밝혔고 cAMP의 수준이 오르기 위해서는 신경펩티 드인 Dh44와 그 수용체 GPCR인 Dh44R1과 Dh44R2가 필요하다는 것을 확인함. 또한 cAMP의 변화는 신경내의 CREBB를 통하여 하위 유전자인 pyx (pyrexia)의 발현을 유도한다는 것을 밝힘. 본 연구로 종 유지 메커니즘을 좀 더 이해할 수 있음.

Langerhans cell histiocytosis (LCH) is a rare disease that arises from an abnormal increase in histiocytes. Due to its rare occurrence, the diagnosis of LCH is often delayed or missed. This report presents a case of LCH in a 16-month-old girl. After biopsy, the patient’s previous medical records were obtained. The records described the presence of a yellowish plaque on the forehead since birth, a characteristic feature of LCH. Earlier knowledge of this medical history would have helped facilitate the diagnosis of LCH. This report aims to inform clinicians of the clinical and histopathological features of LCH in order to aid in the early diagnosis of this disease, which can occur in infancy.

Synovial cysts of the temporomandibular joint are rare. They commonly occur in the wrist, knee and feet. The main symptoms of synovial cysts occurring in the temporomandibular joint include preauricular pain and swelling, and surgical removal is the gold-standard treatment. A 54-year-old woman who presented with swelling of the right temporomandibular joint visited Kyungpook National University Dental Hospital. She had undergone enhanced computed tomography from another hospital, which showed a 1.1 × 0.8 × 1 cm well-defined rounded cystic lesion on the lateral area of the right temporomandibular joint. A synovial or ganglion cyst was suspected. The cystic lesion was surgically removed under general anesthesia and was histopathologically diagnosed as a synovial cyst. Histopathological findings show a lumen surrounded by loose fibrous tissue, and the lining is in a folded form and is composed of synovial cells.

During insect development from embryo to adult, airway clearance in tracheal system occurs episodically each time the molt is completed by performance of the ecdysis sequence. We found that the neuropeptide Kinin is required for normal respiratory fluid clearance or “tracheal air-filling” in fruit fly Drosophila larvae. Disruption of Kinin signaling leads to defective air-filling during all larval stages. Targeted Kinin receptor silencing in tracheal epithelial cells also shows tracheal air-filling defect. On the other hand, promotion of Kinin signaling in vivo through peptide injection or Kinin neuron activation induces premature tracheal collapse and air-filling. Moreover, direct exposure of epithelial cells in vitro to Kinin leads to calcium mobilization in tracheal epithelial cells. Our findings strongly implicate the neuropeptide Kinin as an important regulator of airway clearance via intracellular calcium mobilization in tracheal epithelial cells of fruit fly Drosophila.

이 연구의 목적은 강남 선정릉지역에서 전산유체역학모델(CFD)을 사용하여 도시지역의 흐름 및 열 환경 모의를 검증하는 것이고, CFD 모델의 모의결과와 선정릉 지역의 관측 자료와 비교하는 것이다. CFD 모델은 국립기상과학원과 서울대가 공동으로 연구 개발된 모델이다. CFD_NIMR_SNU 모델은 기상청 현업 모델인 국지예보모델(LDAPS)의 바람성분과 온도성분을 초기 및 경계조건으로 적용되었고 수목효과와 지표 온도를 고려하여 2015년 8월 4일에서 6일까지 강남 선정릉 지역을 대상으로 수치실험을 진행하였다. 선정릉지역에서 수목효과 적용 전후의 풍속을 비교하였을 때 평균 제곱근 오차(RMSE)는 각각 1.06, 0.62 m s−1로 나타났고 수목효과 적용으로 풍속 모의정확도가 향상되었다. 기온은 LDAPS 과소 모의하는 경향을 나타내고 CFD_NIMR_SNU 모델에 의해 향상된 것을 확인하였다. CFD_NIMR_SNU 모델을 이용하여 복잡한 도시지역의 흐름과 열 환경을 자세하고 정밀한 분석이 가능하며, 도시 환경 및 계획에 대한 정보를 제공 할 수 있을 것이다.

Canalicular adenoma is an uncommon, benign salivary gland tumor. It has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate. Rarely, canalicular adenoma can involve the major salivary glands, such as the parotid gland. Only a small number of cases of canalicular adenoma of the parotid gland have been reported in the literature. We report a rare case of canalicular adenoma on the left parotid gland of an 81-year-old man, and present a review of the literature.

Animals must maintain proper balance between energy intake and expenditure. Recently, we descovered the enzymaticco-factor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of theconserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr). Although we observe increased feeding upon lossof Punch and Purple in the adult fat body, loss of Sptr must occur in the brain. We found Sptr expression is requiredin four adult brain neurons that express NPF, the fly homologue of the vertebrate appetite regulator NPY. Mechanistically,we found BH4 deficiency reduces NPF levels, while excess BH4 increases NPF accumulation without altering its expression.

Carcinoma ex pleomorphic adenoma (Ca ex PA) is an uncommon malignant tumor. It is an aggressive salivary carcinoma, arising from a primary or recurrent benign pleomorphic adenoma (PA). The most common clinical presentation of Ca ex PA is a firm mass in the parotid gland. Here we report a case of Ca ex PA, arising from a recurrent benign PA in the right parotid gland, in a 70-year old female patient. The lesion was first diagnosed as a PA and a superficial parotidectomy was performed. Re-operation was performed for recurrent PA. The second recurrence was diagnosed as Ca ex PA.

The ecdysis behavioral sequence in insects is a classic fixed action pattern (FAP) initiated by hormonal signaling. Ecdysis triggering hormones (ETHs) release the FAP through direct actions on the CNS. Here we present evidence implicating two groups of central ETH receptor (ETHR) neurons in scheduling the first two steps of the FAP: kinin (aka drosokinin, leucokinin) neurons regulate pre-ecdysis behavior and CAMB neurons (CCAP, AstCC, MIP, and Bursicon) initiate the switch to ecdysis behavior. Ablation of kinin neurons or altering levels of ETH receptor (ETHR) expression in these neurons modifies timing and intensity of pre-ecdysis behavior. Cell ablation or ETHR knockdown in CAMB neurons delays the switch to ecdysis, whereas overexpression of ETHR or expression of pertussis toxin in these neurons accelerates timing of the switch. Calcium dynamics in kinin neurons are temporally aligned with pre-ecdysis behavior, whereas activity of CAMB neurons coincides with the switch from pre-ecdysis to ecdysis. Activation of CCAP or CAMB neurons through temperature-sensitive TRPM8 gating is both necessary and sufficient to trigger ecdysis behavior. Our findings demonstrate that kinin and CAMB neurons are direct targets of ETH and play critical roles in scheduling successive behavioral steps in the ecdysis FAP. Furthermore, temporal organization of the FAP is likely a function of ETH receptor density in target neurons.