This study was conducted to evaluate the accumulation and distribution of hydrophobically modified glycol chitosan (HGC) as a degradable nanoparticle in the body. To determine the movement of degradable HGC nanoparticles in the body, 20 mg/kg of lutetium177-labeled HGC (Lu177-HGC) with the size ranging from 320 to 400 nm was injected intravenously into ICR mice, and the amount of radioactivity remaining in blood and several organs was measured at various time points during the period of 5 days. In the pharmacokinetics analysis using the Lu177 radioisotope, the free Lu177 was mainly distributed and accumulated in the order of kidney>liver>lung at 1 day after the injection of the radioisotope. However, the Lu177-HGC showed a high distribution of nanoparticles in the order of liver>spleen>kidney during the experimental period of 5 days. These results would provide a basic pharmacokinetics for the use of HGC as a drug carrier in drug delivery system.

The ultimate goal of this study is to assess the accumulation and distribution of hydrophobically modified glycol chitosan (HGC) as a degradable nanoparticle in the body. To understand the movement of degradable nanoparticle HGC in the body, we intravenously injected a dose of 20 mg/kg of Cy5.5-labeled HGC with size ranging from 320 to 400 nm into ICR mice, and measured the amount of fluorescence remaining in blood and several organs at various time intervals. In blood, the level of Cy5.5-labeled HGC was the highest at 15 min, then after 30 min it decreased rapidly and reached a plateau form 30 min to 28 days. In the tissue we confirmed the presence of nanoparticles at high levels in the order of kidney>liver>submandibular gland until 28 days after injection. However, we did not find the presence of the particles in the brain or testes. These results will provide basic information on HGC as a drug delivery agent.

According to the quality standards of the BIO-SRF(Bio-Solid Fuel Products) in Act on the Promotion of Saving and Recycling of Resources enforcement regulations, chloride is regulated to less than 0.5wt.%. The reason why chloride was regulated may generate HCl and dioxin when bio-solid fuel was burnt. Chloride and chloride compounds can be presented the characteristic of corrosiveness. These materials is reacted with iron to produce ferric chloride. Ferric chloride is oxidized to ferric oxide and ferric oxide can cause a pipe corrosion to short boiler life in combustion facility. There are several reactions to reduce Cl concentration in organic wastes and some wastes can be used in nucleophile reaction as reductive agents. Nucleophile(Nu) material can be represented by phosphate, nitrate, sulfate etc. Nu materials can substitute them for chlorine-based compounds(X-: Cl-, Br-, I-). Nu materials can reduce the harmfulness and chlorine concentration by substituting them for chlorine-based compounds of the solid fuel product produced by carbonization. In order to produce solid fuel product from organic wastes, carbonization among pyrolysis processes is suitable because nucleophile reaction should be an endothermic reaction, which heat must be entered to solid fuel product from outside. In this study, sewage sludge is used as a reductive agent to evaluate the characteristics of the reduction reaction in carbonization process because a large amount of Nu material is contained in sewage sludge. In order to evaluate the effect of Nu materials to control chloride in the residue of carbonization, waste wood mixed with sewage sludge was used in carbonization process.