황색육아종성 담낭염은 주변조직을 침투하는 특성으로 인해 담낭암과 감별이 어려우며 조직학적 확진을 위해 담낭 절제술을 시행해야 하는 경우가 많고, 주변조직과의 유착으 로 확대절제술이 필요한 경우가 상당수이다. 소변색 변화를 주소로 내원한 69세 여자환자가 전산화단층촬영 및 자기공 명영상에서 주변조직을 침윤하는 담낭종괴가 발견되었고, 최초에는 담낭암으로 판단하였으나, 조직검사 및 추적 전산 화단층촬영으로 양성 염증 질환의 가능성이 높을 것으로 판단, 스테로이드 치료 시행 후 호전되어 확진을 위해 담낭절 제술을 시행하였고 황색육아종성 담낭염을 진단하였다. 스테로이드 치료로 인해 간조직 침투가 호전되어 광범위 절제 술을 피할 수 있었던 증례로 이를 문헌고찰과 함께 보고하는 바이다.

Transforming growth factor (TGF) family is well known to induce the chondrogenic differentiation of mesenchymal stem cells (MSC). However, the precise signal transduction pathways and underlying factors are not well known. Thus the present study aims to evaluate the possible role of C2 domain in the chondrogenic differentiation of human mesenchymal stem cells. To this end, 145 C2 domains in the adenovirus were individually transfected to hMSC, and morphological changes were examined. Among 145 C2 domains, C2 domain of protein kinase C eta (PKCη) was selected as a possible chondrogenic differentiation factor for hMSC. To confirm this possibility, we treated TGFβ3, a well known chondrogenic differentiation factor of hMSC, and examined the increased-expression of glycosaminoglycan (GAG), collagen type II (COL II) as well as PKCη using PT-PCR, immunocytochemistry and Western blot analysis. To further evaluation of C2 domain of PKCη, we examined morphological changes, expressions of GAG and COL II after transfection of PKCη -C2 domain in hMSC. Overexpression of PKCη-C2 domain induced morphological change and increased GAG and COL II expressions. The present results demonstrate that PKCη involves in the TGF-β3-induced chondrogenic differentiation of hMSC, and C2 domain of PKCη has important role in this process.