Phytic acid (PA) is a naturallu occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plants and mammalian cells. Recently PA has received much attention for its role in anticancer activity. We investigated the preventive effect of PA on the formation of colonic aberrant crypt foci (ACF), a preneoplastic lesion, induced by azoxymethane (AOM). After acclimation for one week, six-week old male ICR mice were fed on the AIN-93G purified diet and PA (0.5% or 2% PA in water) for 8 weeks. The animals were treated with azoxymethane (AOM, 10 mg/kg b.w.) three times (0, 1, and 2 weeks) to induce colonic aberrant crypt foci (ACF). After sacrifice, the total numbers of aberrant crypts (AC) and ACF in colonic mucosa were counted after staining with methylene blue. Blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. AOM treatment without PA induced the total numbers of 85.7 ± 12.9 and 115.2 ± 19.9, respectively. PA at the dose of 2% AC/colon by PA at the dose of 0.5% were 73.4 ± 12.9 and 115.2 ± 19.9, respectively. PA at the dose of 2% significantly decreased the ACF and AC numbers to 56.5 ± 14.6 and 95.4 ± 17.2, respectively (p＜0.01). PA at the doses of 0.5 and 2% decreased the numbers of ACF and AC/colon in a dose-dependent manner. Although some parameters in blood counts and serum chemistry were changed compared with the control, no specific toxicity was found. Theses findings suggest that phytic acid can be a chemopreventive agent for colon carcinogenesis resulting from inhibition of the development of ACF in ICR mice.

This Study aims at looking into the use of oriental medical services in treating hypertension. The first objective to be explored through this study is the morbidity caused by the disease, classifying them by age, gender, and occupation. The second is to determine the regular use of anti-hypertensive medicine and their efficacy in controlling blood-pressure. The third is to investigate the use-rate and satisfaction of oriental medical service. 838 households across the country, were asked to answer questionnaires for the period of time from Apr. to Jun. 2005. The conclusion from the survey can be summarized as following. The age of which the first medical diagnosis of hypertension were made showed lower in males, those with higher education and income. The study showed females were more active in blood-pressure control, with their frequent monitoring of blood-pressure for the past year. With age, people in under 50 age group proved to be less active. The management of high blood pressure was more effective in group with regular dosage compared to group with irregular use of anti-hypertensive medication, but their difference was minimal. Also, group with no medication showed signs of blood-pressure control. The use of oriental medical service for the past year, were more frequent in groups with lower education, either low or high income, old age, females and occupations in agriculture, forestry and fishing industry. Results were similar in both general population and high blood-pressure patient group. Females, people over 51 years old and with lower education showed more intentions in utilizing oriental medical services in the future. Results were similar in both general population and high blood-pressure patient group. It is necessary to offer a more accurate information on oriental medical treatments. Also, a systematic reform to reduce the patient's share of the treatment cost, as well as, heightening public awareness on the infirmity of present blood-pressure management system is crucial.

<Objective> This study were carried out to study to assess the relationship between job characteristics, general characteristics,　health behaviors, and psychosocial distress and suggested the preventive oriental medicine approaches in occupational health area. <Methods> We measured job characteristics(job demand, job control, jop insecurity) by The Karasek's Job Content Questionnaire, health behaviors(smoking, drinking, exercise, coffee), general characteristics at work by a self-administered questionnaire. Psycho social distress was measured by PWI(Psychosocial Well-being Index), a 18-item selfadministered instrument. 370 data for research were collected through the process of oriental health examination with questionnaire in workplace. Statistical analysis was done by t test, oneway ANOVA, and hierarchical multiple regression analysis with SPSSWIN (version 10.0) <Results> Among the 152 respondents, the prevalence of high job strain was 27%(41 persons). The Odds ratio of high job strain was 3.11(95 2.12∼4.11), and those of passive group and active group were 2.01(95 0.83∼2.76) and 1.80(95 0.83∼2.76), respectively. Our results supported the association between psychosocial distress and job strain. <Conclusion> The odds ratio of high strain isolated group(high strain group+low social support) was 3.59(95 2.05 5.13), but the odds ratio of high strain collective group was 1.32(95 0.23 2.41). Social support at work was modifing factor of the association between psycho social distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psycho social distress in this study, and that the strength of the social support was important in maintain health.

Taking good care of the new born babies - from birth to 1st month - is very important and not able to neglected because it can has big effects on the health of rest of their lives. Traditional oriental medicine has a method using detoxicant to wipe out infant oral cavity. So, It must be helpful for baby's health if we use that kinds of drugs nowadays. In procedure of cutting off an umbilical cord, environment of the operating should be kept warm and tools are sterilized to prevent coldness invasion and infection through the cord. and even though the cutting done later, the cord should maintained always clean and warm until it perfectly cut away. The best time of first bath for the new born babies is after 24hours when infant vernix is naturally dried. Warm air and proper water temperature is recommended for bath. Too frequent baths are not recommended. A mother should be in state of relax and comfortable during feeding, and the maternal milk should be in proper temperature and proper quantity. When clothing the new born babies, it is important control body temperature. So it's better clothing them lightly, and protect the new born babies from intense cold and hot, and going out with them outside often for sunbathe when weather is sunny and nice. Development of the brain of the the new born babies is not completed, so keep away from strange things or person can scare babies. According to stated, taking care of the new born babies well, gives them healthy for whole life. So it won't be negligent, and I think all parents want to have babies should learn about new born babies enough.

Acetylcholinesterase(AChE) is an enzyme which hydrolyses acetylcholine into choline and acetate. Glucose and Adenosine-5'-Triphosphate(ATP) are the primary energy source for the brain and therefore defects in glucose metabolism and the mitochondrial system can affect cognitive function. The fact that the level of acetylcholine(ACh), neurotransmitter, glucose and ATP, are found to be decreased in the brain of Alzheimer patients has lead us to focus on the inhibition of AChE for the developmental research of the Alzheimer's disease(AD) treatment. In this paper we describe the effects of herbal medicine 9908(滌痰化瘀湯加減) in vitro and in vivo. As herb 9908 concentraion increased, the Vmax values of AChE from Electric eel were decreased, which showed that the activity of AChE in vitro was decreased. Also herb 9908 inhibit AChE activity in vivo. When herb 9908 was orally administrated to rats, amount of glucose and ATP which are energy source in metabolism, increase in brain and blood of rats. These result are also interesting in their effects for AD treatment compare with comercial drugs such as Cognex and Aricept. Furthermore, when considering the toxic problems of the Cognex and the Aricept, these oriental medicines could be very valuable medicine for treatment of AD. Abbreviation AD: Alzhemer's disease, AChE: acetylcholinesterase, ACh: acetylcholine, ATCh: acetylthiocholine, DTNB: 5,5‘-dithio-bis-2-nitrobenzoate, ATP: Adenosine-5'-triphosphate GAPD: Glyceraldehydephosphate dehydrogenase PGK : phosphoglycerate phosphokinase