This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histopathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2 in the CND group vs. 3.3 ± 0.34 mm2 in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2 in the CND group vs. 2.0 ± 0.33 mm2 in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.

This paper represents the statistical characteristics of sources and receptors for road traffic noise in apartment complex. Also we suggested that the site-specific characteristics of vertical and horizontal distributions in the complex apartment have been derived using a different analysis for evaluating levels of Leq1h by the apartment floor at a given distance from a road in terms of the flow rate, the mean speed of the traffic, and the percentage of the type vehicles in the day and night periods. As a result, the contribution orders of traffic quantity by the type of vehicles showed as followed: light vehicle>medium vehicle>heavy vehicle>motorcycle. Especially, the mixing ratio of entering the road on the heavy vehicle in the daytime was two times higher than that of in the night. The speed in all types of vehicle is in the range of 41 and 81 km/hr and noise level was not significantly different in day and night-time. The sources of road traffic noise had different variations and uncertainties using a random variable and probability distribution. The sound distribution to receptors by the apartment floor showed S curve between 1st floor and 15th floor With the normality test, the normal distributions using Anderson-Darling Test followed 1st, 3th, 13th and 15th floor in the daytime and all floors except 7th floor in the night (p>0.05). And also, the value of the pearson correlation coefficient (r) obtained in this study have significantly different at the range of floor. In conclusion, the results suggested that the distribution characteristics of levels of Leq1h on the sources and receptors of road traffic noise in apartment complex must be improved and developed on the guideline of regulation of road traffic noise.