Traditionally, mistletoe is known as an effective anti-cancer medicinal plant, and lectin is recognized as a major component with cytotoxic and immuno-stimulant activity in mistletoe. A Korean mistletoe lectin (KML) has specificity to galactose and galactosamine and is distinguish from European mistletoe lectin (EML). When we examined the concentration of lectin in mistletoe originated from five different types of host trees, the result indicate that the lectin concentration is variable depending on the host tree. Noticeably, mistletoe from chestnut tree contains ten folds higher lectins than that of an oak tree. We also tested the concentration of KML and crude extract (KM-110) of Korean mistletoe that shows 90% cytotoxicity in L5178Y-ML25 lymphoma cell. In addition, the cells show 90% and 70% viability by the treatment of two neutralizing antibodies of KML, 9H7-D10 and 8B11-2C5 neutralization effect with two monoclonal antibodies of KML, 9H7-D10 and 8B11-2C5. Therefore, the result expected that the mistletoe contain some other cytotoxic components except lectin. Finally, the production of TNF-α and IL-6 by RAW 264.7 cells stimulated with lectin free-crude extract (LFKM-110) following neutralization by 9H7-D10 monoclonal antibody shows higher than that of lectin containing-crude extract (KM-110). These results suggest that the Korean mistletoe lectin ha a great potential to be developed as therapeutic agent of cancer.

In solstices during the solar minimum, the hemispheric difference of the equatorial ionization anomaly (EIA) intensity (hereafter hemispheric asymmetry) is understood as being opposite in the morning and afternoon. This phenomenon is explained by the temporal variation of the combined effects of the fountain process and interhemispheric wind. However, the mechanism applied to the observations during the solar minimum has not yet been validated with observations made during other periods of the solar cycle. We investigate the variability of the hemispheric asymmetry with local time (LT), altitude, season, and solar cycle using the electron density taken by the CHAllenging Minisatellite Payload satellite and the global total electron content (TEC) maps acquired during 2001–2008. The electron density profiles provided by the Constellation Observing System for Meteorology, Ionosphere, and Climate satellites during 2007–2008 are also used to investigate the variation of the hemispheric asymmetry with altitude during the solar minimum. During the solar minimum, the location of a stronger EIA moves from the winter hemisphere to the summer hemisphere around 1200–1400 LT. The reversal of the hemispheric asymmetry is more clearly visible in the F-peak density than in TEC or in topside plasma density. During the solar maximum, the EIA in the winter hemisphere is stronger than that in the summer hemisphere in both the morning and afternoon. When the location of a stronger EIA in the afternoon is viewed as a function of the year, the transition from the winter hemisphere to the summer hemisphere occurs near 2004 (yearly average F10.7 index = 106). We discuss the mechanisms that cause the variation of the hemispheric asymmetry with LT and solar cycle.