This study was conducted to develop the Korean traditional tea and investigate the effects of Shan-shu-yu, Gugiga, Ginseng, Younggi and coffee on the hematology of rat. Gugiga, Shan-shu-yu, Younggi and Ginseng tea were adimistrated 3g/day/rat with feeding, respectively. Coffee was adminstrated 1.8g/day/rat. The mixing ratio of mixed tea were 1:1 (w/w). According to the feeding days (10, 20, 30), enzyme activities and chemical components in serum and change in whole blood were determined. 1. The activities of s-GOT and s-GPT of rat administrated Shan-shu-yu, Young-gi, Gugiga, Ginseng and their mixed tea were increased at the normal ranges, and coffee and it's mixed tea were significantly increased other, group (p〈0.05). 2. In coffee and it's mixture groups, the content of s-glucose and s-cholesterol were remarkably increased (p〈0.05), but in others (except coffee additive group) were decreased than coffee and it's mixture groups. 3. In all groups (except coffee addivite groups), the range of WBC, RBC, Ht and Hb was 7.30-8.00 (×103/mm3), 8.18-9.00 ((×106/mm3), 50-60 (%) and 16.10-17.40 (g/d), respectively and in strict coffee group, the level of WBC, RBC, Ht and Hb was 8.90±0.40, 8.10±0.37, 49±0.38 and 14.90±0.44 (p〈0.05), respectively.

parathion을 rat의 복강내에 매 3일 마다 20회 반복적으로 주사 했을때, 일정한 농도의 parathion을 주사한 rat와 점진적으로 주사량을 증가 시켰을때 rat의 독성정도, 혈액 및 신경조직내 cholinesterase 활성 변화, 혈액내 urea nitrogen 및 creatinine의 함량을 측정한 결과 다음과 같은 성적을 얻었다. 복강내 주사시 rat에 대한 parathion의 는 10.5mg/kg였으며 95% 신뢰한계는 6.6~16.8mg/kg였다. 아급성 독성실험에서는 A군이 50%의 폐사율을 보인데 비하여 B군과 C군에서 각각 57% 및 83%의 폐사율을 보여 parathion에 대한 축적효과가 나타났으며 증체량 측정에서도 A군에서 123 g의 증체량을 보인데 비하여 B군과 C군에서 각각 60.7 g, 및 88.4 g 의 증체량을 보여 parathion 투여군에서 체중 증가량이 감소하였다. 혈장내 cholinesterase 활성도는 A군()에 비해 B군()과 C군()에서 각각 19%, 및 38%의 억제를 보였고 AA군(), BB군() 및 CC군()에서도 A군에 비해 각각 47%, 55%, 71%까지 유의성(P<.05)있는 감소를 보였다. 척수내 cholinesterase 활성도는 A군(2.484U/g)에 비해 B군(1.87U/g)과 C군(1.29U/g)에서 각각 25%, 및 48%의 억제를 보였고 AA군(1.27U/g), BB군(0.71U/g) 및 CC군(0.25U/g)에서도 A군에 비하여 각각 49%, 71%, 및 90%의 유의성(P<.01)있는 억제를 보였다. 뇌의 cholinesterase 활성도에서는 A군(4.67U/g)에 비해 B군(2.52U/g)과 C군(1.32U1U/g)에서 각각 46%, 및 72%로 억제 되었고 AA군(2.48U/g), BB군(1.08U/g) 및 CC군(0.51U/g)에서는 A군에 비해 각각 47%, 77%, 89%까지 유의성(P<.01)있게 억제되는 축적효과를 보였다. 비단백 질소 화합물이 urea nitrogen과 creatinine 함량은 A군에서 각각 와 인데 비하여 B군(, ) 및 C군(, )에서 유의성 있는 차이를 보이지 않았으나 urea nitrogen 함량은 A군에 비해 B군과 C군에서 다소 증가하는 경향을 보였다.

These studies were undertaken to examine the interaction of tamoxifen with sex steroid hormones in rat uterine activity. The uterine wet weights of the immature Tat uterus were examined after the administration of estradiol-l7(1g), tamoxifen(50g), progesterone(lmg). The uterotropic activity in immature ovariectomized rats was observed under various treatment conditions following pretreatment with above drugs. The results obtained were as follows:1) Tamoxifen produced significant increase (p <0.01) in uterine wet weight compared with control group, although the increase was not as great as that seen with estradiol-17. Administration of estradiol-17 together with tamoxifen inhibited significantly the increase of uterine wet weight by estradiol-17 (p < 0.01). Coadministration of progresterone with tamoxifen partly blocked the increase of tamoxifen-induced uterine wet weights by progesterone. 2) Estradiol-17after the estradiol-17 pretreatment discontinued the declining uterine wet weights due to the absence of estrogen support, but uteri continued to increase in weight if daily estradiol-17 was maintained. Administration of tamoxifen on the fourth day of estradiol-17 treatment reduced uterine wet weights within 24 hours, and the weights continued to decline with additional tamoxifen. 3) The modest growth of the uterus induced by three daily injections of 5Opg tamoxifen remained stable for five days, with or without additional tamoxifen treatment. Coadministration of tamoxifen with estradiol17 increased slightly the increase of uterine wet weight by tamoxifen. Coadministration of tamoxifen with progesterone inhibited the increase of uterine wet weight by tamoxifen. 4) The modest growth of the uterus induced by three daily injections of lmg progesterone reduced uterine wet weight to the control level for five days. Commencement of tamoxifen or estadiol-17 injections on the fourth day of progesterone treatment rapidly elevated uterine wet weight.