유신체제시기 1979년 10월 16일부터 20일까지 부산과 마산에서 발생한 부마항쟁은 유신체제의 제반 모순에 대한 도전이었다. 그러나 그로부터 6일 뒤 박정희 대통령이 권부 내 갈등으로 살해되는 10·26사건이 일어남으로써 부마항쟁은 이 사건의 도화선 역할을 한 ‘미완의 항쟁’으로만 남게 되었다. 이 연구의 요체는 ‘부마항쟁의 진실과 역사적 성찰’이란 주제에 걸맞게 부마항쟁이 어떻게 발발하고 전개되었으며, 또 어떻게 진압되었는지를 부산항쟁과 마산항쟁의 주요 쟁점을 통해 비교고찰 하고자 하는 것이다. 특히 대학생과 민중이 주도한 부마항쟁의 시위전개와 경찰과 군에 의한 시위진압이 서로 부딪치면서 박정희 대통령 및 권부에 어떤 영향을 끼쳤는지를 구체적으로 논의해 보고자 한다. 부마항쟁은 올해로 39주년을 맞는 과거사가 되었으나 아직도 진상규명이나 명예회복 등의 문제가 산적해 있어 법제도의 정비 등, 우선적으로 해결할 것이 많은 현대사임에 틀림없다. 그러나 일단의 세력들이 항쟁의 주도자인 양, 여러 가지 기록물이나 증언을 통해서 부마항쟁사의 진실을 호도하고 농단하는 작태로 진실규명에 어려움을 주고 있다. 부마항쟁의 진실규명을 위해서는 객관적인 자료의 획득, 항쟁관련자의 증언 청취나 현지조사 등이 필요하며, 항쟁사의 진실을 호도하고 농단해 온 세력에 대한 법적․사회적 응징과 대응도 필요하다고 본다.

Ganoderma lucidum, a species of the class Basidiomycetes, attracts international attention due to the wide variety of its biological activities and great potential as cosmetic ingredient, such as skin care cosmetics including ‘skin-whitening’. However, there is little information available regarding the tyrosinase inhibitory activity. Therefore, the objectives of this study were to investigate the chemical composition and tyrosinase inhibitory activity of the G. lucidum. To isolate active single compound from G. lucidum (GASC), we conducted ethanol extraction and chloroform fractionation. In addition, we assayed the inhibitoty effect of tyrosinase activity and melanin biosynthesis in B16F10 mouse melanoma cells. In the present study, we identified a GASC, which exhibited inhibitory effects of cellular tyrosinase activity, the protein expression of cellular tyrosinase and tyrosinase-related protein-1, 2. In additional, microphthalmia-associated transcription factor (MITF), as known as crucial regulator of melanogenesis-related genes, was down-regulated by treatment with GASC in a concentration-dependent manner. GASC exhibited significant inhibition of tyrosinase activity and melanin synthesis in B16F10. The finding that melanogenesis inhibitory effect of GASC will contribute to facilitate various approaches of this mushroom for use in skin whitening products.

The aim of this study was to establish the identity of Korean traditional food based on the recorded food preferences during the period of the Chosun Dynasty. Our primary source in this regard was the invaluable, historical document called the "Miam's diary." This important document reveals details of such food preferences from October 1567 to September 1568. By analyzing the income-expenditure trends of virtually every household, this diary was used to describe a vivid traditional food preference of the people during that period. A detailed analysis of the diary reveals the summary of families' characteristics in the 16th century. First, it records the fact that expenditure on food was mainly based on stipend and gifts received. The type of food preferred by the people was diverse in nature; for it included rice, bean, chicken, pheasant, and seafood. However, there were dried or pickled forms too so as to prevent them from undergoing decay. Second, it throws light on the fact that people expended food mainly as a salary for servants. People utilized the income from selling such food items to purchase goods and land. They also used the same either to donate for a funeral or wedding purpose. Third, it records the fact that day-to-day purchase of groceries was mostly based on gift(s) for someone close to them such as a neighbor, colleague, relative, or student. Further, such gifts included small groceries, food items, and clothes. Fourth, based on the data available in the diary, it seemed likely that the gentry families laid emphasis on the customary formalities of a family dating back to as early as the late 16th century. Finally, the document also records the fact that noblemen of the Chosun Dynasty had a notion that they had to extend warmth and affection by presenting generous gifts to their guests at home. Noblemen during that period were very particular in welcoming their guests as they believed that this approach alone would testify their status as noblemen.

The pathological condition of excessive melanogenesis causing freckles, melasma, senile lentigo, pigmented acne scars, and cancer has a critical impact on the wellness of individuals. The mechanism of melanogenesis is related to the expression of melanogenic enzymes. Here, we evaluated the inhibitory effect of pine cone (Pinus densiflora) extracts on melanogenesis. P. densiflora, the Korean Red Pine, is the predominant tree species in the cool, temperate forests of northeast Asia, occurring in pure stands across Korea, Japan, and parts of northern China and Russia. P. densiflora leaves, pollen, and bark have been widely used for traditional medicine, or edible purposes. However, pine cones are rarely used as natural raw materials, although they contain many bioactive phytochemicals. The pine cone ethyl acetate fraction (PEF) showed no toxicity to B16F10 cells at a concentration of less than 100 ㎍/mL. PEF inhibited the expression of microphthalmiaassociated transcription factor (MITF), tyrosinase and tyrosinase-related factors in B16F10 cells treated with 3-Isobutyl- 1-methylxanthine (IBMX). These results suggest that pine cones can be used as an effective natural melanogenesis inhibitory agent.

This study was conducted to investigate the effect of branch extracts of Vaccinium oldhamii (VOB) on melanin synthesis in B16F10 cells. VOB promoted melanin production in absence or presence of α-melanocyte-stimulating hormone (α-MSH) in B16F10 cells. However, VOB did not affect the expression of tyrosinase and TRP-1 associated with melanin synthesis at the mRNA and protein levels in B16F10. But, VOB decreased TRP-2 protein level and induced tyrosinase activation in B16F10 cells. Inhibition of tyrosinase activity and tyrosinase knockdown attenuated VOB-mediated melanin synthesis. In conclusion, VOB may stimulate melanin synthesis through activating tyrosinase activity.

본 연구에서는 약콩(Glycine soja Siebold et Zucc.) 분획 추출물의 미백효능을 관찰하기 위해 B16F10 멜라노마 세포에서 TRP-1 (tyrosinase related protein-1), TRP-2 (tyrosinase related protein-2), 티로 시나제 발현을 평가하였다. 그 결과 약콩 분획 추출물 0.125, 0.25, 0.5, 2.0 mg/mL 농도에서 82% 이상의 높 은 세포생존율을 나타내었다. α-melanocyte stimulating hormone (α-MSH)을 처리한 B16F10 멜라노마 세포에 약콩의 EtOAc 분획 추출물을 처리한 결과 티로시나제 발현이 감소되었으며 TRP-1, TRP-2 단백질 발현이 감소하였다. 이러한 결과는 약콩 분획 추출물이 멜라닌생합성과 관련되는 단백질의 발현을 감소시켜 피 부 미백효능을 나타내는 것으로 기대할 수 있다.

Dendrobium loddigesii (DL) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxidant and anti-inflammation. In the present study, we investigated the whitening effects of DL under various conditions with B16F10 melanoma cells. The DL extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DL extract effectively suppressed the α-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), microphthalmia-associated transcription factor (MITF) and protein expression of tyrosinase were significantly attenuated by DL treatment. These results indicate that DL may be a great cosmeceutical ingredient for its whitening effects.