총수담관 담석에 의한 폐쇄성 황달 발생시 일반적으로 담즙정체형 간기능 이상을 보이나 일부 환자에서는 아미노전이효소가 1,000 IU/L 이상 증가되는 간세포손상형의 간기능 이상을 보여 급성 간염으로 오인되는 경우가 있다. 이에 저자 등은 아미노전이효소가 1,000 IU/L 이상 상승하였고 혈청 ALP 검사치는 정상이며 영상검사에서 담관계 질환이 관찰되지 않아 급성 간염으로 진단 후 치료 중 급성 담관염으로 재진단된 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

This study was conducted in order to investigate the effects of Acer tegmentosum Maxim. extract (ATE) in prevention of liver injury. After oral administration of ATE to SD rats, liver injuries were induced by treatment with CCl₄, galactosamine, or ethionine. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride, and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl₄ or galactosamine, ATE-fed rats showed a lower level of AST and ALT in plasma than ATE-unfed rats. In the case of ethionine-induced fatty liver, triglyceride levels in plasma were reduced in ATE-fed rats, compared with ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected against hepatic failure.

The purpose of this study is to evaluate the changes of liver and gallbladder in patients with acute hepatitis A during transabdominal ultrasonography (US). In this study, we included 61 patients with acute hepatitis A and 50 controls. Wall thickness and lumen diameter of gallbladder were measured for determined the mural edema and hypertonicity of gallbladder. To evaluate the hepatic size and stiffness, two sagittal images of the left lobe of the liver were obtained during the resting state (resting image) and at full inspiration (stress image). The elongation rate was calculated by a formula: (L2-L1/L1)×100 (%); where L1 and L2 are the length of the liver for both the resting and stress image. The elongation rate was compared between controls and patients with acute hepatitis A. The wall thickness and lumen diameter of gallbladder were 7.0±3.5mm, 10.2±9.9mm, respectively. In 21 cases (34%), the lumen of gallbladder was collapsed. The mean diameter of left lobe in patients with acute hepatitis A (10.3±1.4cm)was larger than that of controls (8.2±1.1cm). The elongation rate in patients with acute hepatitis A (8.0±8.8%) was smaller than that of controls (25.5±13.4%). Robust US findings in patients with acute hepatitis A were edematous gallbladder with collapse and hepatomegaly with stiffness.