Purpose: This study was conducted to evaluate simulation-based asthma pediatric care among nursing students. Methods: One group post design was utilized. A total of 148 nursing students were recruited as participants. The data were collected from February 22to June10, 2016. Seven hours of simulation-based asthma pediatric care was conducted. Results: The total mean knowledge score for asthma pediatric care was 3.8, and simulation-based performance score was 8.0. In simulation-based performance, the highest mean score was 2.4 for “oxygenation” category and the lowest mean score was 1.5 for “nursing recording.” There was no statistically significant difference in the level of clinical performance using simulation for the upper, middle, and lower groups according to the theoretical knowledge level. Additionally, no statistically significant correlation was found between the theoretical knowledge score and simulation-based clinical performance score. Conclusion: The findings suggest that simulation-based care involving various scenarios and integrated evaluation tools for clinical nursing performance are required to improve asthma pediatric care among nursing students.