Purpose: This study was conducted to evaluate simulation-based asthma pediatric care among nursing students. Methods: One group post design was utilized. A total of 148 nursing students were recruited as participants. The data were collected from February 22to June10, 2016. Seven hours of simulation-based asthma pediatric care was conducted. Results: The total mean knowledge score for asthma pediatric care was 3.8, and simulation-based performance score was 8.0. In simulation-based performance, the highest mean score was 2.4 for “oxygenation” category and the lowest mean score was 1.5 for “nursing recording.” There was no statistically significant difference in the level of clinical performance using simulation for the upper, middle, and lower groups according to the theoretical knowledge level. Additionally, no statistically significant correlation was found between the theoretical knowledge score and simulation-based clinical performance score. Conclusion: The findings suggest that simulation-based care involving various scenarios and integrated evaluation tools for clinical nursing performance are required to improve asthma pediatric care among nursing students.

Purpose: This study was conducted to evaluate outcome-based delivery care with simulation in nursing student. Methods: One group pre-post design was utilized. 155 participants consisting of nursing students was recruited. The data were collected from august 25 to december 5, 2015. Five hours thirty minutes of outcome-based delivery care with simulations was operated. Results: The item showing the lowest mean score was ‘verbal communication’, the highest mean score was ‘core basic nursing skills’. Conclusion: The findings suggest that it would be useful to use the outcome-based delivery care with simulation in nursing students.

Purpose: This study was to identify relationship between instructor and learner's evaluation in the simulation-based maternity nursing. Methods: The simulation-based nursing education program was taken by 112 fourth year nursing students. 30 item clinical practice competency evaluation tool has been developed for instructor. And 30 item clinical practice competency scale(self reported form) was used for students. Result: The critical items of the simulation-based maternity nursing were suggested in this study. Mean score for clinical practice competency are as follows: student's evaluation 4.0(on a 5-point scale), instructor's evaluation 76.7(on a total 90-point). There was a positive correlation between instructor and learner's evaluation score. Conclusion: These findings will be useful guideline in development direction of qualitative simulation-based nursing education program.

Purpose: This study was to develop a clinical competence scale to assess competence of nursing students in neonatal core nursing management after delivery in the simulation-based clinical situations. Methods: The assessment items developed with 14 items of 3 point scale. An expert panel of 4 professor and 1 nurse reviewed the scale for content validity by using the CVI(Content Validity Index). Following the establishment of content validity, 14 items of the checklist were developed. The simulation-based neonatal core nursing education that consisted of four sessions for 6 hours lecture and practice was provided to 26 small groups. Result: The total mean score of clinical competence in neonatal core nursing care was 20.04. Items with the highest mean score was 1.87 with 'apply clean gloves'. Items with lowest mean score was 1.15 with 'perform the body temperature management to the neonatal'. Reliability of between two evaluation using Cronbach's alpha was .86. Conclusion: This results show neonatal core nursing care assessment tool developed this study had reliability and validity. Further studies are needed to determine property of tool in neonatal core nursing care assessment tool.

Purpose: This study was to develop a clinical competence scale to assess competence of nursing students in postpartum bleeding care in the simulation-based clinical situations. Methods: The assessment items developed with 12 items of 3 point scale. An expert panel of 3 maternity professor reviewed the scale for content validity by using the CVI(Content Validity Index). Following the establishment of content validity, 12 items of the checklist were developed. The simulation-based postpartum hemorrhage nursing education that consisted of four sessions for 6 hours lecture and practice was provided to 32 small groups. Result: The total mean score of clinical competence in postpartum hemorrhage care was 17.34. Items with the highest mean score was 1.88 with ‘introduce myself to the patient'. Items with lowest mean score was 0.19 with 'assess the general conditions'. Reliability of between two evaluation using Cronbach's alpha was .86. Conclusion: This results show postpartum hemorrhage access tool developed this study had reliability and validity. Further studies are needed to determine property of tool in postpartum hemorrhage access tool.

Purpose: This study examined the effects of simulation-mixed maternity nursing practicum on learning attitude, learning satisfaction and clinical practice performance in nursing students. Methods: One group, pre-post design, was utilized with 64 students. The simulation-mixed maternity nursing practicum consisted of intrapartum and postpartum care. Results: The learning attitude and learning satisfaction scores in maternity nursing care showed a significant change in the post-test (t=-5.92, p <.001, t=-7.35, p <.001) and enhanced clinical practice performance. Conclusion: The simulation-mixed maternity nursing practicum was useful in improving the learning attitude and learning satisfaction and clinical practice performance for maternity nursing practicum in nursing students. In conclusion, We recommend for simulation-mixed maternity nursing practicum to increase clinical practice performance of the students.

Purpose: This study examined the effects of simulation-based education on knowledge, self-confidence and satisfaction about maternity core nursing practicum in senior nursing students. Methods: One group, pre-post design, was utilized with 77 students. The simulation -based maternity core nursing practicum that consisted of two sessions each 2 hours long for intrapartum and postpartum care was provided to 6 small groups. Core items of knowledge about and self-confidence in maternity core nursing practicum were measured with 18 items before and after the sessions. Results: The knowledge, self-confidence and satisfaction scores in maternity nursing care showed a significant change in the post-test (t=-13.99, p<.001, t=-21.14, p<.001). Conclusion: The simulation-based maternity core nursing practicum was useful in improving the knowledge, self-confidence and satisfaction scores for childbirth and postpartum care in nursing students. In conclusion, We recommend for maternity core nursing practicum to empower the competency of the students.

마늘의 주요 성분인 allicin 투여 후 유도되는 사람 말초혈액의 단핵구의 유전자 발현에 미치는 allicin 의 효과를 규명하였다. DNA microarray를 이용하여, allicin이 chemokines, cytokine 면역관련 유전자 및 신호전달 관련 유전자의발현을 유도하는 것을 확인하였다. 반대로 allicin은 Thl type의 획득면역 관련 유전자의 발현을 억제하였다. 염증세포에 있어서 allicin은 억제효과 및 자극 효과를 동시에 보여주었다. 이는 allicin이 휴지기 세포에서 먼저 증가시킨 특정 유전자의 발현을 이후에 감소시키는 결과를 보여주는 것으로 positive와 negative 효과를 발휘하는 새로운 기전을 제시하는 것이다. Allicin에 대한 광범위하고 새로운 관심을 고려해 볼 때 본 연구에서 보여주는 많은 유전자의 발현 양상은 좀 더 특정적이고 효과적인 치료법을 고안하는 데 유용할 것이다.

한국산 산초열매와 나무의 휘발성 향기성분을 조사하기 위하여 n-pentane/diethyl ether 용매로 사용하여 SDE방법으로 정유성분을 분리 한 다음에서 57종 그리고 산초나무에서 44종류의 휘발성 향기성분을 확인하였으며, 산초열매의 주요 향기성분은 granyl acetate(29.23%), geraniol(6.80%), p-so-propyl-2`-cyclohexenone(5.53%), phellandral(4.10%) 이고, 산초나무의 주요 향기성분은 4, 6, 6-trimethyl-bicyclo(7.47%), T-carrreol(4.60%), α-cypernone(3.58%) 이었다. 산초열매에만 존재하는 성분이 myrcene, limonene, 1, 8-cinol 등을 포함한 22종이고, 산초나무에만 존재하는 성분이 4-(1-methylethyl)-cyclohexanl, methyl undecycl ketone 등을 포함한 10종의 성분이 확인되었다. 그리고 산초열매보다 산초나무에 palmitic acid(24.34%), myristic acid(3.68%) 등의 고급지방산이 많이 함유되어 있었다.

경북 동해안 일대의 전통 향토식품인 꽁치 과메기의 건조방법을 자연건조와 인공건조로 달리하여 각각 15일 건조기간 중의 핵산 관련물질, 아미노산 함량의 변화를 조사하였다. 핵산 관련 물질은 건조기간중 ADP, AMP 함량은 서서히 감소하는 반면 IMP함량은 증가하여 IMP 축적현상을 보였으며 건조기간 중 inosine과 hypoxanthine의 함량이 증가하였다. K value의 변화는 건조과정 중 점차 증가하여 건조 중 핵산 물질의 부해가 진행됨에 따라 신선도는 떨어지는 것으로 나타났고 핵산 물질의 변화에 의한 신선도 측면에서 인공건조가 자연건조보다 유리한 것으로 나타났다. (특히 IMP 등의 조합에 의한 맛의 상승작용으로 과메기 특유의 맛을 내는 것으로 사료된다.) 총 유리아미노산 함량은 2.98이었으며 glutamic acid, aspartic acid, histidine의 함량이 전체 유리 아미노산의 함량이 34% 이상 차지하였다. 자연 및 인공건조동안 총 유리아미노산 함량은 서서히 증가하였으며 glutamica acid, histidine은 건조 3일째 이후부터 9일째까지 급속히 감소하였고 자연건조보다 인공건조의 감소가 더 크다. 자연 및 인공건조 중 lysine함량은 점차 증가하였으며 threonine은 거의 변화가 없었다.

요석증은 비뇨기과에서 흔히 관찰되는 질환으로서 30∼50대에 많이 발생하고, 남자가 여자보다 발생빈도가 높고, 좌측보다는 우측이 많으며, 문화가 발달한 나라에서는 상부요로 결석이 많으나 후진국에서는 하부요로 결석이 많다. 결석성분은 수산칼슘, 인산칼슘, 인산마그네슘암모늄, 요산, 시스틴 결석과 그들이 혼합결석으로 분류된다. 병태생리학에 따르면, 결석의 발생원인은 요중의 무기질 농도가 과포화 상태가 되면 결정체핵이 생성된다는 과포화/결정체설, 기질관여설, 억제물질의 결핍설, 에피택시설 등이 있고, 상피소체기능항진중, 과칼슘뇨증, 과요산뇨증, 과수산뇨증, 시스틴뇨증외에도 원위세뇨관 산증, 과비타민 D증, 소화기계 질환이 통계적으로 유의성있게 관여된다는 것이다. 본 연구에서는 미란성 위염 환자 K43에서 화학분석법, 적외선 흡수 분석, image analysis법을 사용하여 재발성 상부요로 결석성분을 분석한 결과 제 2 수산칼슘과 인산칼슘의 혼합결석으로 확인되어고, 혈액화학 검사와 요 검사등 임상검사 성적은 정상치를 유지하고 있었다. 따라서 K43의 재발성 요로결석은 보고된 생성원인이나 인자들에 대한 통계수치와는 연관성이 없었으며 미란성 위염으로부터 영향을 받았다는 증거도 없었다.

The rhamnan sulfate extracted from green algae seaweed, Monostroma nitidum was characterized as activity in vitro culture assay with macrophages from mice. Rhamnan sulfate indicated that F-4-3 fraction enhanced glucose consumption, as well as the production of nitrogen dioxide and tumor necrosis factor(TNF). F-4-3 fraction was also augmented IL-1 secretion from those macrophages. Effects of the pretreatment of peritoneal macrophages with rhamnan sulfate F-4-3 fraction and several polysaccharides as relative standard on the production of H₂O₂ induced with unopsonized zymosan A were examined. Pretreatment with polysaccharides inhibited the zymosan A mediated H₂O₂ production by macrophages. The phorbol myristate acetate (PMA) mediated H₂O₂production was not affected by the pretreament. These result suggested that pretreatment of rhamnan sulfate interfered with the interaction of macrophages zymosan A. Rhamnan sulfate inhibited zymosan A mediated production of H₂O₂ by macrophages and F-4-3 fraction was also activator of macrophages.