Purpose: Personal protective equipment (PPE) is critical for protecting healthcare workers from COVID-19 outbreaks. Therefore, this study examined the effects of a nursing simulation education program on PPE use for COVID-19 among nursing students. Methods: We employed a non-equivalent control group post-test design. The experimental group (n=38) engaged in a nursing simulation education program on PPE use. The control group (n=36) received PPE and the opportunity to participate in the same program after the intervention. Further, data were analyzed using descriptive statistics and independent t-test. Results: The experimental group showed significant differences in attitude toward PPE (t=3.21, p=.002) and efficacy of PPE use (t=9.92, p<.001), but not in the intention to care for patients with COVID-19 (t=0.95, p=.343). Conclusion: Nursing simulation education for PPE significantly improved attitude and increased self-efficacy toward PPE among nursing students. However, the intention to care for COVID-19 patients was not changed. Thus, it is necessary to find a way to improve the nursing intention toward COVID-19 patients.