In this study, a response model of a beam structure was established through finite element analysis by analyzing the vibration response to external excitation. The vibration control performance of the beam was then evaluated by applying the narrow-band Fx-LMS algorithm for active structural control. The transfer function was obtained at the error sensor location when the structure was excited and the three-axis actuator was operated. The performance of the active control was investigated with 18 channels for error input and actuator output. When the equipment is exciting, the response of the error sensor is the primary path, and when the inertial 3-axis actuator operates, the response of the error sensor position is the secondary path, and the Fx-LMS algorithm is applied. The simulation was performed by changing the control parameters so that the response of the error sensor can satisfy the target performance. From the results of this study, the acceleration results over time showed about 70% vibration reduction after active control, and the average error value of the error sensor also decreased by about 68%. In addition, it was confirmed that real-time control of a system with 18 sensors and 18 actuators is possible even if the secondary path is configured in two orders.