간행물
International Journal of Oral Biology KCI 등재후보
- 발행기관 대한구강생물학회
- 자료유형 학술지
- 간기 계간
- ISSN 1226-7155 (Print)2287-6618 (Online)
- 수록기간 1977 ~ 2024
- 주제분류 의약학 > 치의학 의약학 분류의 다른 간행물
- 십진분류KDC 515DDC 610
권호리스트/논문검색
Vol.49 No.4 (2024년 12월) 5건
1.
2024.12
구독 인증기관 무료, 개인회원 유료
In 2024, the South Korean government’s research and development budget cuts sparked significant concerns in the scientific community, prompting increased interest in international research funding opportunities. In this regard, South Korea’s upcoming participation as an Associated Country in the European Union’s (EU’s) Horizon Europe offers a timely opportunity. Horizon Europe is the EU’s flagship research and innovation program, running from 2021 to 2027 with a budget of €95.5 billion. It is structured on three key pillars: 1) excellent science; 2) global challenges and European industrial competitiveness; and 3) innovative Europe. South Korea’s direct benefits will focus on Pillar II, which emphasizes global challenges across six clusters, including health, climate, and digital innovation. It should be noted that participation in the program mandates international collaborations, typically involving consortia with diverse expertise. Meanwhile, the National Contact Points network has been expanded to support Korean researchers, offering the necessary resources to facilitate engagement with EU counterparts. By leveraging these opportunities, South Korean researchers aim to collaboratively address global challenges, thus enhancing the nation’s scientific standing.
4,000원
2.
2024.12
구독 인증기관 무료, 개인회원 유료
Endoplasmic reticulum (ER) stress, caused by the accumulation of misfolded or unfolded proteins, activates the unfolded protein response to maintain cellular homeostasis and is implicated in bacterial infections. This study investigated ER stress activation in THP-1-derived macrophages infected with oral bacteria Porphyromonas gingivalis , Prevotella intermedia , Aggregatibacter actinomycetemcomitans , and Streptococcus oralis at an multiplicity of infection of 50 for 4 hours. mRNA and protein expressions related to ER stress were analyzed by real-time polymerase chain reaction and Western blot, while pro-inflammatory cytokines were measured using enzymelinked immunosorbent assay. P. gingivalis induced the highest mRNA expression of XBP1 and PERK, whereas A. actinomycetemcomitans showed elevated GRP78, ATF6, IRE1α, ATF4, and CHOP. P. intermedia strongly expressed PERK, while S. oralis showed higher GRP78, PERK, ATF4, and CHOP expression. Protein analysis revealed S. oralis had the highest phosphorylation levels of eIF2α and IRE1α, while CHOP was most highly expressed in P. intermedia . Pro-inflammatory cytokine expression showed P. intermedia and P. gingivalis elicited the most TNF-α, while P. gingivalis induced the highest IL-1β levels. These findings suggest oral bacteria induce varying levels of ER stress, influencing the progression of oral infectious diseases. Targeting ER stress could offer therapeutic potential for managing inflammatory conditions like periodontitis.
4,000원
3.
2024.12
구독 인증기관 무료, 개인회원 유료
The oral microbiome plays a vital role in maintaining oral and overall health and affects immune responses, digestion, and pathogen suppression. While most studies focus on age groups prone to specific conditions, such as dental caries in children or periodontal disease in older adults, limited data exist on preschool-aged children and young adults. This study investigates the composition and diversity of the oral microbiome between these age groups for enhanced understanding of a healthy oral microbiome. Microbial samples from the supragingival regions of 41 children and 31 young adults in Korea were analyzed using 16S rRNA gene sequencing. Alpha and beta diversity were assessed, and linear discriminant analysis effect size (LEfSe) identified taxa with significant differences in abundance between the groups. No significant differences in alpha diversity were observed between children and young adults however, beta diversity analysis revealed notably compositional differences. At the phylum level, Firmicutes were more abundant in children, whereas Actinobacteria were more prevalent in young adults. Genera such as Veillonella and Lautropia were more abundant among children, whereas Haemophilus and Rothia were more common among young adults. LEfSe analysis identified Veillonella rogosae and Lautropia mirabilis as more abundant in children, whereas Haemophilus parainfluenzae and Rothia dentocariosa were more prevalent in young adults. The observed differences suggest that children’s microbiomes are associated with biofilm development, while young adults’ microbiomes involve biofilm maturation and immune modulation. These findings highlight the age-related shift in oral microbiome composition, emphasizing the importance of monitoring these changes to support long-term oral health.
4,000원
4.
2024.12
구독 인증기관 무료, 개인회원 유료
Periodontal disease has been implicated in the progression of various systemic diseases, including chronic kidney disease (CKD). Recent evidence suggests that infection of Porphyromonas gingivalis , a major periodontal pathogen, may also contribute to vascular calcification in patients with CKD. In the present study, antibody array analysis of serum samples from CKD mice administered with oral P. gingivalis revealed significant alterations in protein expression profiles, with notable interleukin-7 (IL-7) upregulation. We demonstrated that P. gingivalis infection enhances the inorganic phosphate-induced calcification of vascular smooth muscle cells (VSMCs), a pathological process that is characteristically accelerated in CKD. Notably, IL-7 expression was significantly upregulated in the P. gingivalis -stimulated calcification of VSMCs. Moreover, IL-7 knockdown in VSMCs markedly attenuated the P. gingivalis -stimulated calcification of VSMCs and suppressed the expression of osteogenic markers, including alkaline phosphatase and Runt-related transcription factor 2. These findings suggest that IL-7 plays a crucial role in P. gingivalis -stimulated vascular calcification, potentially providing new therapeutic targets for preventing vascular calcification in CKD patients with periodontal infection.
4,000원
5.
2024.12
구독 인증기관 무료, 개인회원 유료
Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic resource for the peripheral nervous system (PNS) and central nervous system (CNS) that is attributable to their capacity for neuronal differentiation. Human dental pulp stem cells (hDPSCs), which exhibit MSC-like traits, can differentiate into neuron-like cells and secrete critical neurotrophic factors; however, their therapeutic potential in peripheral nerve injury remains unexplored. This study investigated the regenerative effects of hDPSC transplantation following sciatic nerve injury (SNI) in rats. Transplantation of hDPSCs, STRO-1+ hDPSCs, or CD146+ hDPSCs after sciatic nerve transection in rats upregulated the levels of β3 tubulin, a marker of immature newborn neurons. Furthermore, the levels of glial cellderived neurotrophic factor, insulin-like growth factor 2, and the neuroregenerative factor NeuroD1 were upregulated. Motor dysfunction in rats with SNI was restored, as demonstrated by significantly higher sciatic functional index scores compared with the sciatic nerve transection group without transplantation. Transplantation of hDPSCs into injured peripheral nerves results in the upregulation of neurotrophic factors, differentiation into immature neurons, and promotion of motor function recovery. This approach holds promise as a valuable therapeutic strategy for repairing injured peripheral sciatic nerves, potentially providing a solution for nerve damage in both the PNS and CNS.
4,500원
