Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.

목적 : 본 연구는 8세에서 19세의 근시 학생을 대상으로 어린이 근시관리 누진 안경렌즈의 착용실태를 조사하고 착용 후 2년간 근시도의 변화를 확인하고자 하였다. 방법 : 2019년 6월부터 2023년 5월까지 수원 G 안경원에서 어린이 근시관리 누진렌즈를 구매한 110명을 대상 으로 근시 진행완화를 위해 렌즈의 착용을 지속하고 있는지 그리고 중도 포기했다면 그 이유를 조사하였다. 그 후 2차 정기방문으로 안경을 다시 교정받은 기록이 있는 72명을 대상으로 초점렌즈(A그룹, 33명)와 어린이 근시관리 누진렌즈(B그룹, 39명)를 착용한 두 그룹으로 나누어 2년간 추적 조사하였다. 결과 : 어린이 근시관리 누진렌즈를 처방받은 110명의 1차 대상자 중 15명(13.6%)이 근시진행 완화 안경 착용 을 중도 포기했으며 이들 중 남자는 11명(73.3%), 여자는 4명(26.6%) 이었다. 또한, 중도 포기한 이유로는 구매의 편의성과 비용문제가 주된 이유로 조사되었다. 1차, 2차, 3차 방문 시기에 평균 등가구면 굴절력은 A그룹에서는 – 2.09±1.43, –2.78±1.52, –3.31±1.55 D이었고, B그룹은 –2.04±1.08, –2.63±1.06, -2.94±1.08 D로 측정되 었다. 각각의 안경을 2년간 착용한 후에 평균 등가구면 굴절력의 변화량은 A그룹에서 –1.22±0.56 D이었고, B그 룹에서는 –0.90±0.51 D를 보였다(p=0.010). 결론 : 8세에서 19세의 근시가 있는 초중고 학생은 2년 간 어린이 근시관리 누진렌즈를 착용한 후에 단초점렌즈 를 착용한 그룹에 비해 근시 진행이 지연되었다. 근시관리 안경렌즈의 성공적인 시장 정착을 위해서는 더욱 다양한 모집단을 장기 추적 관찰하여 그 효과를 연구한 자료가 필요하다고 생각된다.

게임의 끝으로 불리는 엔드게임 콘텐츠는 플레이어가 더 이상 게임에서 즐길 수 있는 콘텐츠가 소비된 현상을 의미한다. 게임 디자이너에게 있어 게임의 끝에 다다랐다는 의미는 그만큼 게임 을 즐겼던 플레이어가 해당 게임에 흥미를 잃고 게임에서 이탈하는 현상을 보이기 쉽다. 많은 게임 제작자, 그리고 디자이너에게 플레이어가 게임에서 이탈하는 행위는 큰 숙제이자 직면해 야 하는 숙제로 다가오고 있다. 게임에서 이탈한다는 것은 더 이상 플레이어가 플레이 했던 게 임을 즐길 이유가 없으며 이는 출시된 게임의 생명이 다했다는 의미이기도 하기 때문이다. 이 에 많은 게임 제작사들이 게임의 끝에서 다음 차기작 준비를 위한 기간 사이 DLC(Downloadable Contents)을 중간에 투입하거나 새로운 패치 업그레이드 등을 통해 게임 의 생명을 연장시키고 있다. 연구는 게임의 끝이 아닌, 추가적으로 게임 플레이어가 게임을 플 레이하는 수단으로서 엔드게임 콘텐츠를 접근하고, 이에 엔드게임 콘텐츠를 지니고 있는 게임 을 분석하여 엔드게임 콘텐츠의 구조를 제안하고자 한다. 이에 플레이어가 더 해당 게임을 찾 으며 게임에서 이탈하는 행동을 억제하는 요인들을 분석한다. 이를 위한 과정으로 장르와 게임 의 형태를 기준으로 게임에서 나타나는 엔드게임 콘텐츠들을 형상화 한 결과, 엔드게임 콘텐츠 설계에 있어 게임 디자이너 뿐만 아니라 게임 제작에 참여하는 모든 구성원들의 관심 아래 플 레이어게 더 관심 받고 지속 가능한 게임 즉 엔드게임 콘텐츠 설계가 가능성을 논의한다.

본 연구를 통해 한국산 Thyas속을 검토하였다. 이 중, T. coronata (Fabricius, 1775)는 성충 및 생식기 도해사진을 기반으로 최초로 그 분류학 적 기재문을 작성하였다. 모든 한국산 Thyas속 종에 대한 분류학적 진단형질 및 분포 정보를 함께 제공하였다.

Background: Self-myofascial release using a foam roller has short-term effects for improving muscle function and joint range of motion (ROM) and reducing delayed onset muscle soreness (DOMS) after exercise. Objectives: The purpose of our study was to examine the muscle physiological changes for each set in self-myofascial release of the hamstring muscles using a foam roller in order to provide basic data for the most effective program composition for improving muscle tension, stiffness, and flexibility of the hamstring muscles. Design: A quasi-experimental clinical trial. Methods: To confirm the effect of self-myofascial release of the hamstring muscles using a foam roller, muscle tone and stiffness of the hamstring muscles were measured. As an intervention method, the study subject performed four sessions of self-myofascial release by moving a foam roller back and forth on the posterior thigh muscle of the right leg. Results: There were statistically significant changes in the stiffness of the biceps femoris and the flexibility of the hamstring muscles. Conclusion: Self-myofascial release with foam rolling is an effective intervention method for increasing hamstring flexibility and ROM, and it is recommended as effective to perform self-myofascial release for three to four sessions to maintain normal muscle tone and stiffness of the hamstring muscles.

In this study, we utilized a multi-step stabilization method, incorporating dry-oxidation, to produce high-density polyethylene (HDPE)-based activated carbon fibers. This stabilization was achieved through electron-beam irradiation, sulfonation, and dry oxidation. The stabilized fibers were carbonized and activated at 900 ℃. The crystallite characteristics of the activated carbon fibers were observed using X-ray diffraction, and their surface morphologies were analyzed through scanning electron microscopy. The textural properties were analyzed using N2/ 77 K adsorption–desorption isothermal curves. And leveraging the microdomain model, we explored the influence of these stabilization methods on the HDPE-based activated carbon fibers texture properties. The results show that HDPE fibers treated with sulfonation only at 100 ℃ for 60 min were not sufficiently cross-linked and were completely decomposed during the carbonization stage. However, the sulfonated fibers treated with the new dry-oxidation process maintained their shapes and were successfully activated. The specific surface area of the resulting activated carbon fibers was as much as 2000 m2/ g.

In this study, Pitch-derived activated carbon (PAC) pellets were by steam activation for automotive carbon canisters. The crystal structure of PAC was analyzed using X-ray diffraction. The textural properties of PAC were studied by Brunauer– Emmett–Teller (BET), Horvath-Kawazoe (HK), and Non-Localized Density Functional Theory (NLDFT) equations with N2/ 77 K isotherm adsorption/ desorption curves. The butane adsorption capacity of the PAC pellets was analyzed according to the ASTM D5228 standard. With increasing steam activation time, the specific surface area and total pore volume of the PAC increased 650–1950 m2/ g and 0.27–1.02 cm3/ g, respectively. The mesopore ratio of PAC increased with increasing activation time and was observed up to 28.4% at 190 min. The butane adsorption capacity of the PAC increased and was observed to range from 10.86 to 51.55%. A close relationship between butane adsorption capacity and pore size (1.47–2.39 nm) was found. Finally, the butane activity of PAC was found to be 51.55% for the steam activated at 950 ℃ for 190 min; this butane activity is 24% better than that of the coconut-derived activated carbon (41.43%) with a similar specific surface area, indicating that pitch is a suitable material for the activated carbon of automotive carbon canisters.

In order to assess the relative importance of providing rural life services for the sustainability of rural communities and determine their prioritization, this study employed Analytic Hierarchy Process (AHP) to derive the relative importance of sectors and items in the realm of life services influencing the quality of rural life. A survey was conducted with three groups of experts. Group I consisted of experts in rural life services and rural environmental research (22 individuals), Group II included government officials responsible for implementing rural agreements in pilot areas (18 individuals), and Group III comprised executives from the Rural Life Improvement Association and 4-H organization working towards improving rural life and society (20 individuals). The analysis results revealed the following facilities as top priority in their respective categories: ‘National and Public Childcare Centers’ for ‘Childcare,’ Elementary and Middle Schools for ‘Education,’ Senior Welfare Facilities for ‘Welfare,’ Cultural Centers and Local Cultural Facilities for ‘Culture,’ Public Sports Facilities for ‘Sports,’ Emergency Medical Services for ‘Healthcare,’ Commercial Facilities in daily routines for ‘Commercial and Residential Services,’ Emergency Safety Agencies for ‘Administration and Security,’ and rural village Shelter for ‘Leisure and Rest.'

Since rice is the main food in Korea, there are no regulations on corn milling yet. Corn is known as one of the world's top three food crops along with wheat and rice, and it is known that 3.5 billion people worldwide use corn for food. In addition, corn mills are not developed or sold in Korea, but the use of corn mills is increasing significantly in many countries in Southeast Asia. In the Philippines, as Korea's rice mill import increases, Korea's KAMICO (Korea Agricultural Machinery Industry Cooperative) and domestic company A agreed to develop a corn mill jointly with PHilMech, an organization affiliated with the Philippine Ministry of Agriculture. However, research on corn milling was very insignificant, so the development was carried out based on the technology of Korea's rice mill. Rice milling is performed by peeling off the skin of rice and producing brown or white rice, so it is carried out by removing the skin and cutting the skin. On the other hand, in the corn mill, the skin of the corn is peeled, pulverized and selected to produce main products suitable for edible use. Therefore, in order to develop a corn mill, processes such as peeling, transfer, grinding, sorting, and by-product separation are required, and suitable parts must be developed. In addition, the performance must be gradually improved through experiments in which corn is repeatedly milled. The Philippines produces 7.98 million tons/year of corn, which is about 100 times that of Korea, and is mostly consumed as a staple food. This is about 10% of the total crop production in the Philippines. In addition, the main cultivation complexes of corn are the mountainous regions of Tarlac or Pangasinan, and the produced corn is 72.4% of the so-called yellow corn called Arabel and Sarangani, and the remaining 27.6% are known as white corn. In this study, it was intended to produce grains of 2.5 mm or less suitable for food for yellow corn and to develop a corn mill for 200 kg per hour. Detailed conditions for development are stipulated as more than 55% of the main product recovery rate, more than 31% of the by-product recovery rate, less than 5% of the raw material loss rate, and more than 80% of the embryo dislocation rate. In this study, to achieve this, the overall process of the corn mill was developed, and the optimal conditions for the corn mill were obtained through the development of parts and empirical tests to improve performance. In addition, it was intended to achieve the development goal by evaluating and analyzing the performance of each part so that it did not conflict.

This study explores EFL English learners’ reactions and achievements when exposed to two types of online learning, pre-recorded lectures and real-time lectures, in a semester-long English reading class. The participants were 60 Korean university English learners who attended both types of online lectures for six weeks each. They studied three parts: reading comprehension for top-down and bottom-up reading skills, grammar, and vocabulary. Midterm and final exams assessed the learners’ achievements, and one online survey was conducted to investigate their reactions. The results showed that the participants preferred to study recordings and were most satisfied with their grammar studies in recorded lectures but preferred real-time lectures for reading comprehension. The study also found that they attained better scores on top-down reading skills and vocabulary learning through recorded lessons and higher scores on bottom-up reading skills and grammar learning through real-time lectures. Finally, the study shows the participants preferred to attend a combination of both online methods. This study suggests salient online learning ways for an English reading course.

The purpose of this study was to develop the Functional golf inner-wear by preventing the injuries and enhancing the performance of the Golf swing by checking the influence of the wearing of the functional golf inner-wear considering golf characteristics on the Swing trajectory and Shot distance. Functional inner-wear effective for golf swing was manufactured using the sports taping method. Changes in driver and iron swing before and after wearing the functional golf inner-wear manufactured in this way were measured using trackman equipment. Measurement variables were limited to Club Speed, Attack Angle, Club Path, Ball Speed, Smash Factor, and Priority. Before and after wearing functional golf inner-wear, there were statistically significant differences in driver club speed, iron club speed, driver etch angle, iron club pass, driver ball speed, driver smash factor, iron smash factor, driver carry, iron carry, and right shoulder joint proprioceptive sensory ability. As a result, functional golf inner-wear is effective for ball speed, impact, and carry by increasing club speed and efficient swing. Future research will focus on the development of functional golf that can improve the swing ability in a short game that plays an important role in the golf game through various sports taping grafting technique, textile, special material, film, Research on functional golf inner-wear.

Effects of glutamic acid (Glu) and monosodium glutamate (MSG) on oxidative stability of oil-in-water (O/W) emulsions with different emulsifier charges during riboflavin (RF) photosensitization were evaluated by analyzing headspace oxygen content and conjugated dienes. Cetyltrimethylammonium bromide (CTAB), Tween 20, and sodium dodecyl sulfate (SDS) were used as cationic, neutral, and anionic emulsifiers, respectively. Glu acted as an antioxidant in CTAB- and Tween-20-stabilized O/W emulsions during RF sensitization, whereas Glu acted as prooxidants in SDS-stabilized O/W emulsions in the dark. However, adding MSG did not have a constant impact on the degree of oxidation in O/W emulsions irrespective of the emulsifier charge. In RF-photosensitized O/W emulsions, the emulsifier charge had a greater influence on antioxidant properties of Glu than on those of MSG.

This study examines the rise of the Body Positive Movement on TikTok and its role as a form of online content activism influencing the fashion design and industry. Through a combination of literature review and case study methodology, the study explores the expression techniques and thematic types of Body Positive Movement on TikTok. Reviews of literature, previous studies, online articles, fashion journals, and relevant search terms on TikTok informed a definition of Body Positive Movement and an analysis of its formation and rise. The research findings confirm the impact TikTok content on Body Positive Movement has on the fashion industry in addressing external factors (i.e., ‘Appearance’, ‘Race’, ‘Aging’, ‘Physical Disability’) and intrinsic factors (i.e., ‘Acceptance of Diversity’, ‘Self-Esteem’, ‘Rejection of Stereotypes’, ‘Appropriate Representation’, ‘Information Provision’). The key external factor , ‘Appearance’, includes subcategories such as ‘Body Shape’, ‘Body Hair’, ‘Skin’, and ‘Facial Features’. TikTok content creators on fashion creatively combine music, emojis, and visual storytelling to exhibit positive self-perception concerning these factors. A significant finding of the study is that short clips predominantly manifesting external factors differentiate into informative or enlightening videos associated with intrinsic factors. The study underscores Body Positive Movement's important influence on the fashion industry from design to presentation.

본 논문은 회분식 반응기에서 습식 산화법으로 합성한 칼륨 페레이트(VI)에 의한 난분해성 아조 염료Reactive Black 5의 분해 과정을 연구하는 것을 목적으로 한다. 수용액에서 RB5의 분해는 pH, Ferrate (VI) 투입량, 초기 농도, 수용액 온도 등 다양한 변수의 조건에서 연구되었다. RB5 경우에는 최대 분해 효율은 pH 7.0에서 63.2%가 달성되었으며, 이 실험 조건에서 얻은 kapp 값은 190.49 M-1s-1 으로 나타났다. 온도 또한 가장 중요한 매개 변수 중 하나로 연구되었으며, 그 결과로부터 온도(45°C까지)를 증가시키면 페레이트(VI)에 의한 아조 화합물 염료의 분해 효율이 증가하고, 온도가 45°C를 초과하면 분해 효율이 저하되는 것으로 나타났다.

This study explores the profound impact of varying oxygen content on microstructural and mechanical properties in specimens HO and LO. The higher oxygen concentration in specimen HO is found to significantly influence alpha lath sizes, resulting in a size of 0.5-1 μm, contrasting with the 1-1.5 μm size observed in specimen LO. Pore fraction, governed by oxygen concentration, is high in specimen HO, registering a value of 0.11%, whereas specimen LO exhibits a lower pore fraction (0.02%). Varied pore types in each specimen further underscore the role of oxygen concentration in shaping microstructural morphology. Despite these microstructural variations, the average hardness remains consistent at ~370 HV. This study emphasizes the pivotal role of oxygen content in influencing microstructural features, contributing to a comprehensive understanding of the intricate interplay between elemental composition and material properties.

In the merger-driven galaxy evolution scenario, dust-obscured quasars are considered to be an intermediate population between merger-driven star-forming galaxies and unobscured quasars; however, this scenario is still controversial. To verify this, it is necessary to investigate whether dust-obscured quasars have higher Eddington ratio (λEdd) values than those of unobscured quasars, as expected in the merger-driven galaxy evolution scenario. In this study, we derive black hole (BH) masses of 10 dust-obscured quasars at z ∼ 2, during the peak period of star-formation and BH growth in the Universe, using a newly derived mid-infrared (MIR) continuum luminosity (LMIR)-based estimator that is highly resistant to dust extinction. Then, we compare the λEdd values of these dust-obscured quasars to those of unobscured type-1 quasars at similar redshifts. We find that the measured log (λEdd) values of the dust-obscured quasars, −0.06 ± 0.10, are significantly higher than those of the unobscured quasars, −0.86 ± 0.01. This result remains consistent across the redshift range from 1.5 to 2.5. Our results show that the dust-obscured quasars are at their maximal growth, consistent with the expectation from the merger-driven galaxy evolution scenario at the epoch quasar activities were most prominent in the cosmic history.

The Spectro-Photometer for the History of the Universe, Epoch of Reionization and Ices Explorer (SPHEREx) will provide all-sky spectral survey data covering optical to mid-infrared wavelengths with a spatial resolution of 6.′′2, which can be widely used to study galaxy formation and evolution. We investigate the galaxy-galaxy blending in SPHEREx datasets using the mock galaxy catalogs generated from cosmological simulations and observational data. Only ∼0.7% of the galaxies will be blended with other galaxies in all-sky survey data with a limiting magnitude of 19 AB mag. However, the fraction of blended galaxies dramatically increases to ∼7–9% in the deep survey area around the ecliptic poles, where the depth reaches ∼22 AB mag. We examine the impact of the blending in the number count and luminosity function analyses using the SPHEREx data. We find that the number count can be overestimated by up to 10–20% in the deep regions due to the flux boosting, suggesting that the impact of galaxy-galaxy blending on the number count is moderate. However, galaxy-galaxy blending can marginally change the luminosity function by up to 50% over a wide range of redshifts. As we only employ the magnitude limit at Ks-band for the source detection, the blending fractions determined in this study should be regarded as lower limits.

A force-free field (FFF) is determined solely by the normal components of magnetic field and current density on the entire boundary of the domain. Methods employing three components of magnetic field suffer from overspecification of boundary conditions and/or a nonzero divergence-B problem. A vector potential formulation eliminates the latter issue, but introduces difficulties in imposing the normal component of current density at the boundary. This paper proposes four different boundary treatment methods within the vector potential formulation. We conduct a comparative analysis of the vector potential FFF solvers that we have developed incorporating these methods against other FFF codes in different magnetic field representations. Although the vector potential solvers with the new boundary treatments do not outperform our poloidal-toroidal formulation code, they demonstrate comparable or superior performance compared to the optimization code in SolarSoftWare. The methods developed here are expected to be readily applied not only to force-free field computations but also to time-dependent data-driven simulations.

In recent years, the energy storage sector has experienced a notable transition toward the use of organic electrodes. This shift is largely attributed to their superior energy density, cost-effectiveness, and eco-friendliness. However, there is a main drawback that the organic molecules oftentimes suffer shuttle phenomenon across the separator due to their high solubility in the organic electrolyte. In addition, the low electrical conductivity of organic materials is also detrimental, thereby requiring a large amount of carbon additives (up to 40 wt. %) in the electrode. In this perspective, addition of carbon additives with the desirable amount, which can prevent organic molecules from being dissolved into the liquid phase as well as provide the electrical conductivity. While N,Nʹ-dimethylphenazine (DMPZ) was investigated as a model material, we compared two carbon additives with different surface areas and functional groups. We carefully scrutinized the structural effect of carbon additives on the cycle-life performance of the organic electrode.