Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders. However, clinical trials of human ESCs cause heavy ethical concerns. With the derivation of iPSCs established by reprogramming from adult somatic cells through the transgenic expression of transcription factors, this problems would be able to overcome. In the present study, we tried to differentiate porcine iPSCs (piPSCs) into endothelial cells (ECs) for stem cell-based therapy of vascular diseases. Methods: piPSCs (OSKMNL) were induced to differentiation into ECs in four differentiation media (APEL-2, APEL-2 + 50 ng/mL of VEGF, EBM-2, EBM-2 + 50 ng/ mL of VEGF) on cultured plates coated with matrigel® (1:40 dilution with DMEM/F-12 medium) for 8 days. Differentiation efficiency of these cells were exanimated using qRT-PCR, Immunocytochemistry, Western blotting and FACS. Results: As results, expressions of pluripotency-associated markers (OCT-3/4, SOX2 and NANOG) were higher observed in all porcine differentiated cells derived from piPSCs (OSKMNL) cultured in four differentiation media than piPSCs as the control, whereas endothelial-associated marker (CD-31) in the differentiated cells was not expressed. Conclusions: It can be seen that piPSCs (OSKMNL) were not suitable to differentiate into ECs in the four differentiation media unlike porcine epiblast stem cells (pEpiSCs). Therefore, it would be required to establish a suitable PSCs for differentiating into ECs for the treatment of cardiovascular diseases.
Lyophyllum decastes has been used for culinary purpose. The present study was conducted to evaluate the antioxidant and anti-inflammatory effects from methanol, acetone, and hot water extracts of L. decastes fruiting bodies. The acetone and methanol extracts showed the higher 1,1-diphenyl-2-picryl-hydrazy radical scavenging activities than that of the hot water extract at 0.5–2.0 mg/mL and was comparable to the BHT, the positive control. The ferrous ion chelating effects of the mushroom extracts at 0.5–2.0 mg/mL were significantly higher than that of BHT. The reducing power of acetone extract (2.12) was significantly lower than that of BHT (2.73) at 2.0 mg/ mL. The mushroom extracts also showed inhibitory effects on production of nitric oxide (NO), and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide-induced murine macrophage cells in a concentration dependent manner. In vivo anti-inflammatory experiment on carrageenan-induced hind-paw edema of rat model, the acetone extract of the mushroom significantly suppressed the carrageenan-induced rat hind paw edema of rats in a dose dependently. The results suggest that the fruiting bodies of Lyophyllum decastes are a good natural resource of antioxidant and anti-inflammation.
Recently, as ESG management has become an important issue, major companies in the automotive parts manufacturing industry are conducting ESG evaluations of their suppliers for the purpose of supply chain management. The results of these evaluations are being incorporated into contractual agreements. However, many small and medium-sized enterprises(SMEs) are lacking in their capacity and resources to effectively respond to ESG evaluations. Furthermore, existing ESG management guidelines do not provide an industry-specific guidance, making it necessary to establish industry-specific guidelines that SMEs can refer to. Therefore, in this study, the evaluation Indicators of ESG supply chain assessments are surveyed, which is conducted by domestic major automotive parts companies and global automobile manufacturers. Then 56 supply chain ESG evaluation Indicators are derived. Also, ESG management indicators for SMEs is analyzed through the Importance-Performance Analysis(IPA), based on an interview of expert groups. Therefore, this study could propose industry-specific ESG guidelines, based on the results of the derived indicators, which reflects the need for SMEs to practice ESG management within certain boundaries.
A study on webGl efficiency in Unity servers was conducted. There are various ways to upload a build file made with Unity to a web server. In fact, to classify it that way, it would not be an exaggeration to say that there are as many developers as there are. In this paper, it is mainly classified into four types and introduced. First, there are ways to package and distribute the Unity project itself, distribute it as a standalone or mobile build, distribute it as a webplayer build, and distribute it as a WebGL build. I would like to briefly introduce each method, look at the simplest of them, the distribution method in WebGL, and study the efficiency of this method in detail. Through this study, we can use Unity for the first time to help people who are thinking of deploying servers or are interested in basic engines and server upload methods. In this paper, we will first introduce the simplest way of building WebGL, then explain and compare the four distribution methods, and finally compare them with the efficiency of the WebGL method. This will support opinions on efficiency.
본고는 북한의 지속가능발전목표(SDGs) 이행 현황을 파악하여 북한이 직면한 도전과제와 문제점을 제시한다. 북한은 SDGs 이행 의지를 표명해 왔으며 2021년 자발적국별검토(VNR)를 실시하였다. VNR 보고서와 여러 문헌자료에서 나타난 북한 SDGs의 특이점은 국가 SDGs 수립과 운영과정에서 선택적 수용과 상당한 내용적 변형이다. 본고에서는 북한 SDGs 이행의 특징을 검토하면서 국가 SDGs 실행과 추진체계에서 나타나는 한계를 구체적으로 파악한다. 북한의 SDGs 이행지표와 통계자료를 분 석하여 본고는 북한의 최근 경제·사회 상황과 SDGs 이행과 관련된 환경문제 실태를 제시한다. 빈곤 감소와 SDGs 진전을 위해 북한의 국제협력을 위한 노력이 필요하며, SDGs와 관련된 분야에서 국제 사회의 인도적 대북 원조가 추진되어야 할 것이다.
Recently, there are some outdoor floor advertising lighting devices as one of the active marketing methods. However, for outdoor use, there are many restrictions due to the Outdoor Advertisement Act, according to requiring high-output heat generation, waterproofing, and AC power, etc. The purpose of this study is to develop a Duo Light product optimized for indoor use through publicity and information guidance in normal times and automatic evacuation route guidance display in case of disaster, in conjunction with disaster safety. To that end, patent search and patent association analyses were conducted, and a comparative analysis with commercial products was conducted as a case study. In addition, prototypes were designed and produced through the review of operation principles, where field environment surveys and self-tests were conducted. Also, technology roadmaps were presented by preparing plans for expandability and advancement of products. For the analysis of technology commercialization, the feasibility of technology commercialization was examined through the analysis of Jolly’s Model and Lean Canvas Model. The results of this study will be able to contribute to minimize human damage through the effective response to disasters, which can increase the effect of indoor advertising by using the proposed indoor floor advertising lighting device in advertising and disaster situations.
Recently, the importance of impact-based forecasting has increased along with the socio-economic impact of severe weather have emerged. As news articles contain unconstructed information closely related to the people’s life, this study developed and evaluated a binary classification algorithm about snowfall damage information by using media articles text mining. We collected news articles during 2009 to 2021 which containing ‘heavy snow’ in its body context and labelled whether each article correspond to specific damage fields such as car accident. To develop a classifier, we proposed a probability-based classifier based on the ratio of the two conditional probabilities, which is defined as I/O Ratio in this study. During the construction process, we also adopted the n-gram approach to consider contextual meaning of each keyword. The accuracy of the classifier was 75%, supporting the possibility of application of news big data to the impact-based forecasting. We expect the performance of the classifier will be improve in the further research as the various training data is accumulated. The result of this study can be readily expanded by applying the same methodology to other disasters in the future. Furthermore, the result of this study can reduce social and economic damage of high impact weather by supporting the establishment of an integrated meteorological decision support system.
현재까지 전세계적으로 Periphyllus allogenes (개성진사진딧물)은 무시성충세대에 대한 형태학적 정보만이 보고되었다. 본 연구에서는 2021 년부터 2022년까지 한국 가평군, 홍천군에서 그동안 P. allogenes의 알려지지 않았던 간모, 유시성충 세대를 채집하여, 이들에 대하여 형태학적 정 보, 분포지역, 기주식물, 생태 사진을 처음으로 보고한다.
본 연구에서는 한국산 미기록속인 밑들이자루맵시벌속(신칭)과 미기록종인 밑들이짧은자루맵시벌(신칭)을 처음으로 보고한다. 밑들이자루 맵시벌속은 잎벌류에 기생하는 것으로 알려져 있으며, 배마디 끝부분이 위쪽으로 굽어져있는 것이 특징이다. 본 논문에는 미기록속, 미기록종의 기 재문과 사진을 제공한다.
In recent years, young Chinese consumers have become more favorably inclined toward products relating to traditional culture. Therefore, this study aimed to develop a textile design that incorporates traditional Chinese patterns and cultural symbolism that will appeal to consumers from the MZ generation (millennials and Generation Z). Through a literature search for traditional Chinese patterns and symbols regarded as auspicious, our design concept and motives were established. We selected peony, lotus, and frog motifs as representative of a “wealth and eternal prosperity” design theme. In textile design work 1, we used hand drawing and watercolor techniques, color transformation with Adobe Photoshop, and colorway and end-use 3D simulation with TexPro. The 3D simulation work suggests that this textile pattern is suitable for women’s outerwear, mufflers, and tote bags. Textile design work 2 conveyed the ‘wealth and eternal prosperity’ design theme and had a graceful mood that embodied the nobility of the lotus flower whilst also encompassing the symbolism of money and status. The end design is a modern reinterpretation of traditional Chinese patterns and motifs. As such, it is hoped that it will satisfy the needs of young consumers for cultural values yet offer a unique new aesthetic distinct from existing textile designs. These qualities can be expected to enhance the competitive market value of textiles bearing this design.
The online shopping market is expanding, with online shopping malls now subdivided into personal computer(PC) and mobile versions. Meanwhile, various efforts to promote online sales are being carried out in a bid to improve performance, and detailed research is required to inform such strategies. The purpose of this study was to classify online shopping mall types into PC fashion malls and mobile fashion malls with the aim of assessing sales promotion satisfaction and investigating the relationship between sales promotion satisfaction and consumers’ behavioral intentions. Data were collected by a survey firm in June 2023, and 248 copies of the data were used for analysis. SPSS 28.0 was used to process the data, and frequency analysis, factor analysis, reliability analysis, and regression analysis were performed. The satisfaction factors for various sales promotions used by PC and mobile fashion shopping malls were empirically subdivided in consideration of consumer perspectives, and potentially effective marketing strategies were presented. Differences were observed in the type of satisfaction with sales promotion between PC fashion shopping malls and mobile fashion shopping malls and in the effect of sales promotion satisfaction on behavioral intention. Based on the study’s findings, effective sales promotion strategies that can increase satisfaction and enhance behavioral intention may be developed and implemented through the use of various and different sales promotion strategies in PC and mobile fashion shopping malls.
The objective of this study was to explore the symbolism associated with phoenix patterns in China and the temporal aesthetic characteristics of these patterns found in Dunhuang Mogao Grottoes. The study involved collecting examples of clothing designs featuring phoenix patterns from China Fashion Week and the Vogue website, spanning from spring and summer of 2016 to fall and winter of 2022. After collecting and organizing these examples, representative cases were selected for analysis. The objective was to identify effective techniques for incorporating phoenix patterns within the context of Dunhuang Mogao Grottoes and provided insights for future clothing design and textile pattern design research. Phoenix patterns boasted a lengthy history and were laden with symbolic meaning. Early renditions of phoenix patterns found at Mogao Grottoes in Dunhuang were relatively simplistic in design, mainly employing elements like rhythm, coordination, balance and symmetry to convey a sense of nature and gravity. Over time, these patterns evolved under the influence of the prevailing cultural backdrop, employing repeated emphasis to portray notions of abundance and tenacity. Furthermore, regarding the use of phoenix patterns in clothing, there were four prevalent expression techniques: embroidery, beading, printing, and knitting. Traditional techniques like embroidery and beadwork often prioritized aesthetic features like coordination, emphasis, and symmetry, thereby showcasing the opulent characteristics of phoenix patterns. On the other hand, printing and knitting techniques used a single phoenix pattern or a modified version to simplify designs by emphasizing or repeating aesthetic characteristics while adhering to a modern artistic approach.
We investigate the provenance of detrital garnets in Middle-Upper Jurassic sandstone of the Mino terrane, an accretionary complex in Southwest Japan, based on their chemical composition. The garnet grains in the Mino sandstone are mostly Fe-rich (almandine) and slightly Mg-rich (pyrope) species derived from high-grade metamorphic and intermediate to acidic plutonic rocks. The composition and interpreted origin of the garnets are generally consistent with those of metamorphic and igneous rocks of the Yeongnam Massif on the Korean Peninsula, a possible source region suggested in previous studies. In addition, two single grains of chromian spinel, an accessory mineral found in mafic to ultramafic rocks such as mantle peridotite, were found in one of the Mino sandstone samples. This finding suggests the possible presence of mafic to ultramafic rocks in the source area. The results of this study provide complimentary evidence for establishing a comprehensive tectonic and paleogeographical framework for the Mesozoic East Asian continent.
예이츠는 아일랜드의 음유시적 전통과 당대 유럽의 지식사회에서 강한 영향력을 발휘한 부동의 미학을 연결지어 본인만의 독특한 비극론을 전개한다. 유럽 상징주의 드라마가 자신의 연극론 형성에 갖는 잠재력을 예리하게 간파한 예이츠는 특히 벨기에 극작가 모리스 마테를링크가 주창한 “정적 드라마”에 영향을 받는다. 동시에 그리스비극을 아폴로와 디오니소스적 욕망 사이에 존재하는 긴장의 산물로 바라보는 니체의 비극 철학에 매료된다. 본 연구는 예이츠의 비극 이론을 니체철학과 마테를링크의 극이론의 창의적 수용이라는 관점에서 바라보고 분석하며 그 장단점을 논의한다. 특히 ‘비극적 환희’라는 극적 효과가 극형식과 연계되는 지점에서 발생하는 문제들에 주시한다. 예이츠는 그가 가졌던 사실주의에 대한 강한 반감 때문에 마테를링크의 일상성과 니체의 아폴로적인 욕망에서 보이는 형식의 중요성을 간과하게 된다.
This study aimed to establish the optimal conditions for producing gluten-free noodles by varying the amount of pregelatinized rice flour added to the regular rice flour and investigating their quality characteristics. With an increase in the amount of added pregelatinized rice flour, the brightness of the noodles decreased, and the color became more yellow both before and after cooking. Adding pregelatinized rice flour to the noodles also increased hardness, elasticity, chewiness, stickiness, and adhesiveness. The textures of the two groups of samples (PR-10 and PR-15) were similar to that of the control, indicating comparable structural characteristics. Furthermore, the absence of gluten made it inherently challenging to form gluten-free noodles. Still, adding pregelatinized rice flour improved the processability of the dough, leading to better noodle formation. An optimal addition of 15% pregelatinized rice flour was deemed suitable for optimal noodle formation in gluten-free noodles. This study established blending conditions using pregelatinized rice flour to improve the poor processability of gluten-free noodles. The findings are expected to be valuable for the industry’s future development of gluten-free processed food.
In recent years, the marketing literature has given considerable attention to the concept of online consumer misbehaviour. However, this increased interest has resulted in a significant accumulation of knowledge, leading to fragmentation and confusion in the field. This situation has serious implications for both researchers and practitioners, as it impedes the development of a coherent and unified understanding of the field. To address this issue, this paper presents a systematic review aimed at consolidating and organizing the available research on online consumer misbehaviour. The paper provides a conceptualization and operationalization of the concept of OCM. Additionally, the paper identifies and discusses the existing theories used in the field of OCM research.
This paper explores the relationships of various cognitive, attitudinal, and behavioural responses of e-discount sales promotion technique preferences consumers have when making purchases through online food delivery services (OFDS). This paper highlights new findings towards expanding e-discount and sales promotion literature and thus provide relevant implications.
From the standpoint of developing a transformative service to create improvements in collective wellbeing (Anderson & Ostrom, 2015), evidence of a sport–resilience relationship is gradually accumulating in the literature (Kim et al., 2022). Sport management and social science scholars are making considerable efforts to understand how sport entities with transformative services can contribute to consumer resilience—an intervention through a sport consumption experience that affects people’s abilities to cope with adversity (Inoue et al., 2022; MacIntosh et al., 2020). However, little is known about the sport industry and spatial consumer behavior in terms of consumer resilience. Although previous researchers have identified a macro-level association between sport industry and community resilience from a bird's eye view (Kim et al., 2021), it could not determine how and where sport industry at a macro level can be related to individual-level resilience through metaphors of Consumer Desire. Specifically, the spatial patterns of sport consumption (i.e., consumer spatial behavior) can be a result of sport consumer behavior affected by spatial context upon heterogeneous features of sport industry across regions (Kim et al., 2021) in the environment–behavior paradigm (Olsson & Gale, 1968). The macrolevel clustering of the sport industry in a region (environment) can be a community resource to provide individuals with the opportunity for sport consumption (behavior), which promotes the micro-level psychosocial factors for sport consumer resilience (Inoue et al., 2022). Furthermore, recent work illustrates heterogeneous spatial interaction at the regional level of the sport industry and individual-level sport consumption (Kim et al., 2022), suggesting the elaboration of cross-level spatial interaction models (Kim et al., 2021). Accordingly, in this study we aim to not only (a) determine spatially heterogeneous interactions in the association between sport industry and consumer spatial behavior in affecting consumer resilience, but also (b) identify what effect spatial interaction has on cross-level relationships. Using data focused on a multiscale-based nested geographic structure (e.g., individual-level consumption by zip code, county, state, and nation) that could elucidate the sport consumer spatial behavior, We collected multiple types of data from Florida, including the location quotient of the main seven sport industries (e.g., sport facilities) and socioeconomic factors (e.g., social vulnerability) at the county level from secondary sources. In addition, we acquired individual-level data from Qualtrics panels (1,107 Florida residents) to measure sport consumer spatial behavior (e.g., location-based sport consumption experience) and consumer resilience using the Connor-Davidson Resilience Scale. To address spatial interaction and heterogeneity, we used a comprehensive analytical model for global and local spatial analysis, including a spatial multilevel mediation (SMM) model and multiscale geographically weighted regression (MGWR) model. As a result of the SMM model, the county-level cluster of sport facilities affected individual-level participatory sport consumption, which enhanced consumer resilience (cross-level interaction effect). However, considerable spatial non-stationarity appeared in the spatial interaction, indicating interregional interactions in the cross-level effects within a county. The results of MGWR indicated significant spatially heterogeneous patterns in the association between the cluster of sport facilities and participatory sport consumption. That is, it was clarified that the spatial heterogeneous effects of the clustering of sport facilities on sport consumer spatial behavior are associated with consumer resilience. This empirical interdisciplinary work, including sport management, geography, and consumer psychology, advances knowledge of consumer spatial behavior and resilience by demonstrating heterogeneous spatial interactions. Practically, the current study calls for spatial management planning and strategy in sport industry for enhancing consumer resilience through spatial sport consumption, considering spatially varying patterns.
As interactive marketing devices that serve as proximity-marketing tools, AI-powered voice assistants (VA) provide consumers with highly innovative convenience, which in turn fosters consumer–brand relationships (Wang, 2021). This research aims to explore the role of AI-powered VAs as a positive technology that offers consumers a sense of positive experiences, thus contributing to building a consumer-brand relationship. Based on the positive technology paradigm and transformation of flow strategy, this research conducted a 2 (locus of agency: high, machine-centric vs. low, human-centric) by 2 (brand image and voice congruency effect: incongruent vs. congruent) between-subjects experimental design. Then, ANOVA and structural equation modeling (SEM) analysis were conducted to explain how perceived control, flow, and happiness induced by the interaction with brands’ AI-powered VAs lead to the formation of brand loyalty under the moderating influences of brand image and VA’s voice congruency. A total of 316 participants were recruited via Prolific. The ANOVA analysis highlights the importance of user-centric agency, as people tend to desire to control their environment (White, 1959). Further, the results suggest that the congruency between brand image and VAs also leads people to positive reactions, as it improves their comfort and control (Rodero, Larrea, & Vázquez, 2013). SEM analysis results found that perceived control was a crucial factor that led participants to flow experience (Ghani et al., 1991). Further, this study found that perceived control could lead to a much broader aspect, such as an increase in happiness. Therefore, the overall study findings support the potential of AI-powered VAs as a positive technology. This research contributes to human-machine interaction, positive technology paradigm, and VA literature. In addition, this study provides beneficial insights for marketers and app developers.
Synced advertising (SA) has grown in popularity due to its ability to facilitate multitasking and personalize ads to the media content users consume. Research on the effects of SA has been limited, but it has been suggested that repetition and personalization with SA will lead to a stronger, lasting impression. However, there are concerns that SA could be perceived as intrusive and lead to privacy issues. This study seeks to explore how the consumer paradox between perceived relevance and privacy concerns may affect the outcome of the advertisements.