Purpose: This study was aimed to provide in-depth understanding of male nurses’ work adaptation experience and suggest future directions for nursing interventions for them by synthesizing individual qualitative findings. Methods: Qualitative meta-synthesis method suggested by Sandelowski and Barroso was utilized. A total of 6 qualitative studies’ findings were synthesized to describe male nurses’ experience of work adaptation in clinical settings. Results: The major task regarding male nurses’ work adaptation was ‘planting himself in the workplace.’ Its contextual and related factors to the task include: extraordinary choice for men, female-centered hierarchical work culture, gender difference vs. interindividual difference, stereotyped view on ‘male’ nurses, strengthening work identity of nursing profession, and dim future even after many years of experience. Conclusion: The findings illuminated the necessity of orchestrated efforts from both female and male nurses to form work environments overcoming gender bias and promoting adaptation of male nurses in clinical settings.