Pluripotency and self-renewal capacity of human embryonic stem cells (hESCs) are retained by hESCs related genes as OCT4, SOX2 and NANOG. These genes are shown high expression level in diverse cancer cells and have potential role in the carcinogenesis. On the contrary to this, several genes which are up-regulated in the differentiated hESCs are involved to suppress the carcinogenesis or proliferation of cells. We discovered several genes in immortalized lung fibroblast (WI-38 VA13) by suppression subtractive hybridization. Among them, we focused chromosome 6 open reading frame 62 (C6orf62) which is uncharacterized, mapped to 6p22.3 and generated to Hepatitis B virus X-transactivated proteins (HBVx-transactivated proteins, XTP). Aim of this study was to characterize C6orf62 through analyzing of expression pattern in various cell lines. Expression of C6orf62 was significantly up- regulated in diverse normal cell lines than cancer cell lines. And C6orf62 was up-regulated in differentiated hESCs (endothelial cells, neural cells) compared to those of undifferentiated hESCs. Also, C6orf62 in WI-38 cells was highly up-regulated during G1/S transition of the cell cycle. Taken together, C6orf62 is shown expression pattern similar to differentiated hESCs-associated genes which down-regulated in cancer cells. Therefore, we assume that C6orf62 may participate to suppress the proliferation and to induce differentiation through regulating the cell cycle.

목적 : Dynavision을 이용한 성인 남녀의 시각운동 반응 속도를 측정하여 정상인의 표준치를 밝히고, 임상에서 이 도구를 이용한 훈련을 시행할 때 대상자의 성별을 고려하여 적용함을 목표로 실험을 실시하였다. 연구방법 : 대상자는 대학생 62명을 대상으로(남: 31, 여: 31), 나이는 19～27세로, 평균나이는 21.48±2.19세이었다. 국소적인 시각적 주의력과 주변 시각적 주의력 그리고 시지각 전체 영역에서 시각 탐색, 시각반응의 측정 및 훈련하도록 고안된 dynavision의 여러 훈련 프로그램 중 본 연구에서는 self-paced 60초와 240초 프로그램을 사용하였다. 결과 : 남녀 두 그룹간 시각운동 반응 속도에서 유의한 차이를 보였는데, self-paced 60초와 240초 훈련 프로그램 모두에서 남자들이 여자들보다 반응 속도가 빠르게 나타났다(p<0.05). 결론 : Dynavision을 시지각 손상 환자를 평가하고 훈련시킬 때 성별에 따른 정상 수행 속도를 고려하여 적용하여야 할 것이다.