대장 내시경 후에 발생한 급성 담낭염은 매우 드문 증례로 알려져 있다. 그러나 담낭염의 위험인자를 가진 환자에서 대장 내시경 후에 복통이 발생했을 경우, 반드시 담낭염을 감별진단해야 한다. 아직까지 정확한 발생 원인에 대해 밝혀진 바는 없으나 대장 내시경 전처치 과정에서 발생한 탈수, 대장 내시경에 의한 대장 점막 손상 등이 보고되었다. 저자들은 대장 내시경후 복통의 원인중 드문 질환인 급성 담낭염을 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.

The purpose of this study was to determine the content of phenolics and various anthocyanin compounds, and antioxidant and anticancer activities of the extracts from pomergranates, which were produced in two different regions including Goheung, Korea and California, USA. These pomergrantes were divided into juice, pericarp, and seed parts and each part was extracted with 95% methanol. Content of total phenolics [mg chlorogenic acid equivalents/kg DW] was highest in pericarp, followed by juice and seeds from pomergrantes in both regions. The anthocyanins identified in pomegranate fruit were cyanidin-3,5-diglucoside chloride (Cy3,5G), cyanidin-3-O-glucoside chloride (Cy3G), delphini din-3,5-di-O-glucoside chloride (Dp3,5G), delphinidin-3-O-glucoside chloride (Dp3G), pelargonidin- 3,5-di-glucoside chloride (Pg3,5G), and pelargonidin-3-glucoside chloride (Pg3G). Among these, cyanidin-3, 5-diglucoside chloride (Cy3,5G) was the major anthocyanin in California pomegranate fruit juice and Goheung pomegranate fruit pericarp. DPPH (1,1-diphenyl-2-picryl hydrazyl radical) free radical scavenging activity was dose-dependently increased, and was higher in pericarp part than juice or seed parts from pomergrantes in both regions. By MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay, pericarp extracts from pomergrantes in both regions showed the highest anticancer activity, which was higher on Calu-6 for human pulmonary carcinoma than SNU-601 for human gastric carcinoma. Correlation between polyphenols and anticancer activity on Calu-6 was determined to be in the range of r2=0.8904 to 0.9706.