On pig farms, the highest mortality rate is observed among nursing piglets. To reduce this mortality rate, farmers need to carefully observe the piglets to prevent accidents such as being crushed and to maintain a proper body temperature. However, observing a large number of pigs individually can be challenging for farmers. Therefore, our aim was to detect the behavior of piglets and sows in real-time using deep learning models, such as YOLOv4-CSP and YOLOv7-E6E, that allow for real-time object detection. YOLOv4-CSP reduces computational cost by partitioning feature maps and utilizing Cross-stage Hierarchy to remove redundant gradient calculation. YOLOv7-E6E analyzes and controls gradient paths such that the weights of each layer learn diverse features. We detected standing, sitting, and lying behaviors in sows and lactating and starving behaviors in piglets, which indicate nursing behavior and movement to colder areas away from the group. We optimized the model parameters for the best object detection and improved reliability by acquiring data through experts. We conducted object detection for the five different behaviors. The YOLOv4-CSP model achieved an accuracy of 0.63 and mAP of 0.662, whereas the YOLOv7-E6E model showed an accuracy of 0.65 and mAP of 0.637. Therefore, based on mAP, which includes both class and localization performance, YOLOv4-CSP showed the superior performance. Such research is anticipated to be effectively utilized for the behavioral analysis of fattening pigs and in preventing piglet crushing in the future.

시설 재배지에 음식물류폐기물 혼합 가축분 퇴비 사용이 늘어나고 있다. 이에 본 연구는 음식물류폐기물 혼합 가축분 퇴비(Food Waste Compost with manure, FWC) 연용 시 시설 토마토(Solanum lycopersicum L.)의 생육과 수량에 미치는 영향을 구명하기 위해 3년간 수행하였다. 퇴비 처리는 사용량에 따른 효과를 알아보기 위하여 농촌진흥청 시설 토마토 표준 시비량(N-P2O5-K2O=20.4-10.3-12.2 kg 10a-1)의 총 질소량 기준 100%로 하여 무기질 비료 반량 + FWC 정량(NPKFWC1), 무기질 비료 반량 + FWC 2배량(NPKFWC2), 무기질 비료 반량 + FWC 3배량 (NPKFWC3)을 처리하였다. 또한, 무기질 비료 사용량에 따른 변화를 퇴비와 비교하기 위해 무기질 비료 반량(NPK 50%) 및 무기질 비료 정량 (NPK 100%, Control) 처리하였다. 초장은 FWC 처리구가 대조구 대비 높았으며, SPAD-502 값은 NPKFWC2에서는 증가하였으나, NPKFWC3는 대조구 대비 낮아지는 경향을 보였다. 3년차 수확 후 토양 pH의 경우 NPKFWC3에서 6.5로 가장 높은 수치를 보였으며, 토양 EC는 NPKFWC1에서 9.5 dS m-1로 가장 높았고, NPKFWC3 처리구에서 6.9 dS m-1 가장 낮은 값을 보였다. 3년간 전체 처리구 간 과실의 평균 횡경, 종경, 당도는 차이가 없었다. 수량은 NPKFWC2까지는 높았으나, NPKFWC3에서는 오히려 대조구보다 낮아지는 경향을 보였다. 따라서 무기질 비료 반량에 음식물류폐기물 혼합 가축분 퇴비 처리 시 추천 시비량 대비 2배량까지는 생육 및 수량이 증가하나 3배량에서는 오히려 감소하는 것으로 판단된다.

목적 : 정상안에서 조도에 따른 눈의 굴절력과 동공 크기의 동적변화를 측정하고, 동공 중심점의 이동량과 방향을 알아보고자 하였다. 방법 : 2020년 7월부터 2020년 9월까지 경기도 지역 안경원에 원용 안경 처방을 위해 내원했던 안과적인 질환 및 각막 굴절 교정 수술 경험 없는 성인 29명(남 14명, 여 15명) 58안을 검사하였고, 평균 나이는 35.62±14.48세였다. 전자동 수차 분석기를 이용하여 조도에 따른 눈의 굴절력, 동공 중심점의 변화 값을 측정하 였고, 각각 3회씩 측정하여 평균값을 사용하였다. 통계 프로그램 SPSS를 이용하여 조도 변화에 따라 명소시와 암소시에서의 굴절력, 그리고 동공 중심의 이동량을 비교 분석하였다. 결과 : 조도에 따라 구면 굴절력은 –2.80 D에서 -2.94 D로 평균 –0.14 D 만큼 변화하였다(p<0.001). 원주 굴 절력은 –0.93 D에서 -0.98 D로 평균 –0.05 D가 증가하였다(p<0.001). 동공 중심점의 평균 이동량은 수평 방향으로 0.14 mm, 수직 방향 0.13 mm만큼 이동하였다. 방향 별 동공 중심점 이동은 양안에서 상측 35안(60.3%), 하측 20안(34.5%), 코측 25안(43.1%), 귀측 33안(56.9%) 이동하였다. 양안에서 동공 중심점 이동은 수평방향으 로 높은 상관관계가 있었고(r=0.700), 수직방향으로는 낮은 상관관계가 있었다(r=0.244). 결론 : 조도가 어두워질수록 구면굴절력은 (-)방향으로 커지고, 동공 크기가 증가하며, 동공 중심은 수평과 수직 방향으로 모두 이동하였다. 따라서 야간 활동 안경렌즈를 조제할 때는 굴절력 변화와 동공 중심 이동에 따른 시력의 질적 저하를 고려해야 할 것으로 생각된다.

The objective of this experiment was to determine the effect of supplementation of hot melt extrusion (HME) processed Zn sulfate on growth performance, nutrients digestibility, small intestinal morphology and excretion of Zn in weanling pigs. A total of 200 piglets of mixed sex randomly allotted to four treatments on the basis of initial BW (7.15±0.81 kg). There were five replicates in each treatment with 10 pigs per replicate. The experimental treatments consisted of: 1) basal diet containing ZnSO4; 2) basal diet containing Zn-Methionine (ZnMet); 3) basal diet containing low level of nano-Zn as HME (ZnHME50); 4) basal diet containing medium level of nano-Zn as HME ZnSO4 (Zn-HME75). The average daily gain was improved by the ZnMet and ZnHME75 compared with the pigs fed ZnSO4 supplemented diets (p=0.009). Moreover, ZnHME75 and ZnMet affected on the ATTD of CP during phase 2 (p=0.014). The villus height (VH) was affected by increasing when pigs fed diets supplemented the ZnHME75 (P=0.044). The pigs fed diets supplemented ZnHME50 had significantly the lowest (p=0.037) Zn content in liver compared with other treatments. The Zn content in the feces was significantly higher (p<0.001) in ZnSO4 and ZnMet compared with ZnHME50 or ZnHME75. In conclusion, it could be concluded that dietary Zn can be reduced by 25% with ZnHME without any detrimental effect on performance of weanling pigs.

Background: The objective of this study was to make colloidal dispersions of the active compounds of radix of Angelica gigas Nakai that could be charaterized as nano-composites using hot melt extrusion (HME). Food grade hydrophilic polymer matrices were used to disperse these compound in aqueous media. Methods and Results: Extrudate solid formulations (ESFs) mediated by various HPMCs (hydroxypropyl methylcelluloses) and Na-Alg polymers made from ultrafine powder of the radix of Angelica gigas Nakai were developed through a physical crosslink method (HME) using an ionization agent (treatment with acetic acid) and different food grade polymers [HPMCs, such as HP55, CN40H, AN6 and sodium alignate (Na-Alg)]. X-ray powder diffraction (XRD) analysis confirmed the amorphization of crystal compounds in the HP55-mediated extrudate solid formulation (HP55-ESF). Differential scanning calorimetry (DSC) analysis indicated a lower enthalpy (ΔH = 10.62 J/g) of glass transition temperature (Tg) in the HP55-ESF than in the other formulations. Infrared fourier transform spectroscopy (FT-IR) revealed that new functional groups were produced in the HP55-ESF. The content of phenolic compounds, flavonoid (including decursin and decursinol angelate) content, and antioxidant activity increased by 5, 10, and 2 times in the HP55-ESF, respectively. The production of water soluble (61.5%) nano-sized (323 ㎚) particles was achieved in the HP55-ESF. Conclusions: Nano-composites were developed herein utilizing melt-extruded solid dispersion technology, including food grade polymer enhanced nano dispersion (< 500 ㎚) of active compounds from the radix of Angelica gigas Nakai with enhanced solubility and bioavailability. These nano-composites of the radix of Angelica gigas Nakai can be developed and marketed as products with high therapeutic performance.

Background : The objective of this study was to make colloidal dispersion of the active compound was characterized nano-composite from radix of Angelica gigas Nakai using hot melt extrusion (HME). Therefore, food grade hydrophilic polymer matrices was used to disperse compound in aqueous media. Methods and Results : Extrudate solid formulations (ESFs) mediated various HPMCs (hydroxypropyl methylcellulose) and Na-Alg polymer from ultrafine powder of radix of Angelica gigas Nakai was developed through physical crosslink method (HME) with ionization agent (treatment of acetic acid) and food grade polymer [HPMCs such as HP55, CN40H, AN6 and sodium alignate (Na-Alg)]. X-ray powder diffraction (XRD) analysis confirmed the amorphization of crystal compounds in extrudate solid formulations mediated HP55 (HP55-ESF). Differential scanning calorimetry (DSC) analysis indicated a lower enthalpy (ΔH = 10.62 J/g) of glass transition temperature (Tg) in HP55-ESF. Infrared fourier transform spectroscopy (FT-IR) reveled new functional groups produced in HP55-ESF. Phenolic compound, flavonoid (including decursin and decursinol angelate) and antioxidant activity increased at 5, 10 and 2 times in HP55-ESF. Water solubility (61.5%) nano size (323 ㎚) particle was achieved in the HP55-ESF. Conclusion : Nano-composites have been developed utilizing melt-extruded solid dispersions technology by food grade polymer enhanced nano dispersion (< 500 ㎚) of active compound from radix of Angelica gigas Nakai with enhanced solubility and bioavailability. This nano-composites of radix of Angelica gigas Nakai developmental and marketed products to enable therapeutic performance.

Background : The root of Angelica gigas Nakai is used as a traditional herbal medicine in Korea for the treatment of many diseases. Poor water solubility of the active compounds from A. gigas Nakai is a major obstacle to bioavailability. Methods and Results : This work aimed to enhance the solubility of active compounds by a chemical (viz. surfactant) and physical (HME, hot melt extrusion) crosslinking method (CPC) in A. gigas Nakai. Infrared fourier transform spectroscopy (FT-IR) revealed multiple peaks in extrudate solids representing new functional groups including carboxylic acid, alkynes and benzene derivatives. Differential scanning calorimetry (DSC) analysis of the extrudate showed lower glass transition temperature (Tg) and lower enthalpy (ΔH) [Tg: 43℃; ΔH: <6 (J/g)] compared to the non-extrudate (Tg 68.5℃; ΔH: 123.2) formulations. X-ray powder diffraction (XRD) analysis revealed amorphization of crystal materials in extrudate solid. In addition, enhanced solubility (53%), nanonization (403 ㎚), and higher amount of extracted phenolic compounds were achieved in the extrudate solid compared to non extrudate (36%, 1499 ㎚, respectively). Among the different extrudates, acetic acid and span 80 mediated formulations showed superior extractions efficiency. Conclusion : We conclude that the HME successfully enhanced the production of amorphous nano dispersions of phenolic compound including decursin from extrudate solid formulations. human dermal fibroblasts, which is, associated with the regulation of procollagen biosynthesis resulting from AMRP-induced TGF-β1 expression and the mitogenic activity in HDF cells, and therefore, is expected to reduce the age-dependent loss of extracellular matrix proteins.

CBCT는 치료부위의 정확도 향상에 유용하지만, 반복적인 사용으로 피폭선량이 높아지는 단점이 있다. 이에 본 연구에서는 차폐체를 사용한 모의실험과 선량감소 효과를 데이터화하여 CBCT 시행 시 선량 저감화를 위한 기초자료를 제공하고자 한다. 본 연구에서는 MCNPX를 통해 CBCT를 모사하여 광자선을 분석한 후, UF-revised 인체 모의 피폭체를 대상으로 흉복부 촬영 시 장기의 흡수선량을 계산하였다. 이 때, 차폐체(납, 안티몬, 황산바륨, 텅스텐, 비스무 스) 유무와 차폐 재질에 따른 장기선량을 평가하였다. 차폐를 하지 않고 CBCT 촬영을 하였을 경우 유방과 척추에서 선량이 높게 계산되었으며, 식도와 폐에서 선량이 낮게 계산되었다. 차폐체 재질에 따른 선량은 황산바륨, 안티몬, 비스무스, 납, 텅스텐 순으로 선량이 높게 계산되었다. 차폐체 유무에 따른 선량 감소율을 평가해 보면 흉선(73.6%), 유방(59.9%)에서 가장 차폐율이 높고, 폐(2.1%), 척추(12.6%)에서 가장 낮은 차폐율을 보였다.

Background: The root of Angelica gigas Nakai is used as a traditional herbal medicine in Korea for the treatment of many diseases. However, the poor water solubility of the active components in A. gigas Nakai is a major obstacle to its bioavailability. Methods and Results: This work aimed at enhancing the solubility of the active compounds of A. gigas Nakai by a chemical (using a surfactant) and physical (hot melt extrusion, HME) crosslinking method. Fourier transform infrared spectroscopy revealed multiple peaks in the case of the extrudate solids, attributable to new functional groups including carboxylic acid, alkynes, and benzene derivatives. Differential scanning calorimetry analysis showed that the extrudate soilid had a lower glass transition temperature (Tg) and enthalpy (ΔH) (Tg : 43℃, ΔH : < 6 J/g) as compared to the non-extrudate (Tg : 68.5℃, ΔH : 123.2) formulations. X-ray powder diffraction analysis revealed the amorphization of crystalline materials in the extrudate solid. In addition, enhanced solubility (53%), nanonization (403 ㎚), and a higher amount of extracted phenolic compounds were achieved in the extrudate solid than in the non-extrudate (solubility : 36%, nanonization : 1,499 ㎚) formulation. Among the different extrudates, acetic acid and span 80 mediated formulations showed superior extractions efficiency. Conclusions: HME successfully enhanced the production of amorphous nano dispersions of phenolic compound including decursin from extrudate solid formulations.