초기배아의 발생과정동안 배아와 모체에서 발현되는 여러 cytokine은 착상을 위한 신호물질로 중요한 역할을 한다. 그 중 interleukin-1 (IL-1)는 배아와 모체간의 상호 신호전달체로서 성공적인 착상을 위한 필수적인 요소로 작용한다고 알려져 있다. 따라서 본 연구에서는 초기배아의 발생과정에 있어서 IL-1 유전자의 역할을 규명하기 위해 생쥐 초기배아에서의 IL-l 유전자의 발현양상을 역전사중합효소연쇄반응을 통해 조사하였고, IL-l 유전자의

To predict diffusion and movement of air pollutants in coastal urban region a numerical simulation shoud be consider atmospheric flow field with land-sea breeze, mountain-valley wind and urban effects. In this study we used Lagrangian particle dispersion method in the atmospheric flow field of Pusan coastal region to depict diffusion and movement of the pollutants emited from particular sources and employed two grid system, one for large scale calculating region with the coarse mesh grid (CMG) and the other for the small region with the fine mesh grid (FMG). It was found that the dispersion pattern of the pollutants followed local circulation system in coastal urban area and while air pollutants exhausted from Sasang moved into Baekyang and Jang moutain, air pollutants from Janglim moved into Hwameong-dong region.

In genneral, Businger expression is used for determining a turbulance diffusion coefficient. In this study, it is applied to the surface elements of cities such as Asphalt, Ground, Grass, Pond. We set up 5 m-height bar and measured the dry temperature and wet temperature at the height of 0.13, 0.27, 0.5, 1.0, 3.0, 5.0 m. In addition we measured the wind gradient and wind velocity at the height 3 m, solar radiation continuously for 48 hours on the surface. Compared the measured data to Businger expression, the result showed that Businger expression can be well applied to the complex surface of the city.

To predict reasonably the movement and the concentration of the pollutants in the coastal area. A simulation model should be prepared considering detail topography with land-sea and the urban effects, and the resolution near the source. The explicit method can not be applied due to the unstability of the numerical calculation in high horizontal-grid resolution, while the ADI scheme satisfied with the high horizontal grid resolution and can be used in the fine mesh system which shows the detail topography, atmospheric flow The ADI method which studied the high horizontal grid resolution was excellent. The two dimentional model used in the study using ADI method is proved as a reasonable model to predict the wind field in any small scale area including mountainous coastal urban area.

Dispersion characteristics of air pollutants in the mountainous coastal area are investigated in considering with the mesoscale local circulations using a two dimensional numerical model with two kinds of topograpy of 500m and 300m. In the model, land-sea breezes and mountain-valley wind are mainly considered under the condition of the absence of large scale prevailing flow in the circulation analysis, and the pollutants dispersion is traced by the Lagrangian methods. According to the results, the wind velocity is affected by topography and is stronger in the case of 500m height mountain than that of 300m, the pollutants that source is near the coast transported over the mountain and dispersed to behind inland area. It is classified that the topography change control affects the wind velocity and the circulations. The pollutants that source is different transported and concentrated to behind inland and/or diffused to the sea area by the combination of the wind system with topographic changes. The results can be applied to the air pollution control with the arrangement design of industrial area and the planning of coastal developments.