항생제의 오남용은 세균의 항생제 내성을 증가시켜 세균감염에 의한 질병 치료에 어려움을 초래한다. 본 연구에서는 동애등애유충으로부터 분리된 펩타이드의 신장에서의 폐렴간균 감염 억제 효능을 관찰하였다. 마우스는 비강을 통해 폐렴간균을 감염시키고 1일 후 펩타이드를 마우스에 근육 주사로 투여하였다. 10일 후 마우스를 희생하여 신장에서 세균 감염증을 조사하였다. 대조군에 비해 펩티드를 투여한 마우스의 신장에서 세균 감염증상, 몸무게의 감소가 유의하게 억제되었고 생존률이 농도 의존적으로 증가하는 것으로 나타났다. 이러한 결과들은 동애등애로부터 분리된 펩타이드가 폐렴 간균의 신장에서의 감염증상을 억제할 수 있음을 보여준다. 따라서 동애등애로부터 분리된 펩타이드는 효과적인 항생제 개발에서 가능성 높은 후보물질이 될 수 있을 것이다.
Background: Scapular dyskinesis is characterized by altered scapular position and motion. Specifically, excess activation of the Upper trapezius (UT) combined with decreased Lower trapezius (LT) and Serratus anterior (SA) have been observed. The Standard push-up plus exercise (SPP) is considered as a therapeutic exercise for increasing SA activity and maintaining the scapular kinematics. In addition, Using the Sling surface can lead to higher muscle activity. However, the advantage of an unstable surface has been uncertatin. Objects: To compare the activation of the UT, LT, and lower serratus anterior (LSA) muscles during various push-up plus exercises with and without sling in subjects with scapular dyskinesis. Methods: Total 18 male subjects with scapular dyskinesis were recruited. The UT, LT, and LSA electromyographic activities and the UT/LSA and UT/LT EMG activity ratios were measured during three push-up plus exercises with and without sling. Two-way repeated of analysis of variance was used to determine the statistical significance. Results: The UT activity was significantly lower in all postures without sling than that with sling. In addition, the LSA activity was significantly greater without than with sling, and significantly large in SPP, Low back supported push-up plus (LSPP), and Quadruped push-up plus. Additionally, the UT/LSA and UT/LT activity ratios were lower in SPP and LSPP without sling than with the other four push-up plus exercises. Conclusion: The push-up plus without sling were considered to decrease UT and increase LSA activity compared with exercises with sling. Furthermore, SPP without sling seems to be a more effective exercise for increasing LSA activity and lowering the UT/LSA and UT/LT activity ratios in scapular dyskinesis subjects.
The shrinkage variation of Low Temperature Cofired Ceramics(LTCC) limits the size of the substrates that impose limitations on embedded passive components. This paper focuses on the method of minimizing or controlling planar shrinkage and reducing distortion during firing. The laminated sheets of alumina and glass were sintered at varying temperature, and depending on the amount of the glass ceramics. When the sintered of multi-layer structure with , the glass infiltrated entirely into layer at the temperature of about or higher.
The magnetosphere is often perturbed by impulsive input such as interplanetary shocks and solar wind discontinuities. We study how these initial perturbations are propagating within the magnetosphere over various latitude regions by adopting a three-dimensional numerical dipole model. We examine the wave propagation on a meridional plane in a time-dependent manner and compare the numerical results with multi-satellite and ground observations. The dipole model is used to represent the plasmasphere and magnetosphere with a realistic Alfven speed profile. It is found that the effects of refraction, which result from magnetic field curvature and inhomogeneous Alfven speed, are' found to become important near the plasmapause. Our results show that, when the disturbances are assumed at the subsolar point of the dayside magnetosphere, the travel time becomes smaller to the polar ionosphere compared to the equatorial ionosphere.