Hydrogen isotopes (H, D, T) separation technologies have received great interest for treatments of tritiated liquid waste produced in Fukushima. In addition, the separated deuterium and tritium can be utilized in various industries such as semiconductors and nuclear fusion as expensive and rare resources. However, separating hydrogen isotopes in gas and liquid forms still requires energyintensive processes. To improve efficiency and performance of hydrogen isotope separation, we are developing water electrolysis, cryosorption, distillation, isotope exchange, and hydrophobic catalyst technologies. Furthermore, an analytical method is studied to evaluate the separation of hydrogen isotopes. This presentation introduces the current status of hydrogen isotope research in this research group.

By Foreign Trade Act and the relevant laws, any organization which intends to export strategic items shall be classified whether the products, S/W, or technology are strategic items and obtain an export license from the Nuclear Safety and Security Commission (NSSC) in case those are nuclearrelated strategic items. The NSSC and KINAC conduct outreach activities to enhance the recognition and implementation of nuclear export and import control. However, ensuring that all target organizations identify and comply with relevant legislation and laws is difficult. Therefore, the government and regulators should continuously make efforts to reduce blind spots for nuclear export and import control. KINAC established the National Nuclear Technology Information Collection and Analysis System (NNTICAS) to find nuclear-related companies through online website information of various companies and to list organizations that handle nuclear-related strategic items. Based on the NICE corporate information website, NNTICAS finds related companies using dynamic collection methods through interactions such as search word input, search button input, check box click, and collected text from each company website using static collection methods through URL address access and HTML source code extraction. After that, the text contained on the company website is analyzed to check whether the predefined normalized word is included, and if the normalized word appears at a certain number or higher, it is judged as a potential target company dealing with nuclearrelated strategic items. Information on the potential target company is compared with the export controlled item list and finally classified as a target company dealing with nuclear-related strategic items. According to the comparison a manually analyzed result of potential target companies and finally selected target companies NNTICAS, it is confirmed that predefined normalized words need to be more detailed, and a controlled item list such as axes (0B001.b.2) needs to be additionally processed. In addition, if the collection is repeated without completing the previous classification of the collected corporate information, it is also possible to collect companies in cosmetics, semiconductors, and displays. Although it was confirmed that some supplementation is needed to use this system to select target companies for the outreach activity, it is also confirmed that target companies for outreach activity can be expanded through this system and is expected to increase the implementation rate and reduce the blind spot for nuclear export and import control.

Since the 1992 ‘Joint Declaration of South and North Korea on the Denuclearization of the Korean Peninsula’ was agreed, various negotiations and policies have been conducted. There were policies such as CVID, Strategic Patience, Top-Down Approach, Calibrated Practical Approach, Audacious Initiative and the Geneva Agreement, and 9.19 Joint statement by the six-party talks were signed to denuclearize Korean Peninsula. However, starting with the first nuclear test in 2006, North Korea conducted six nuclear tests to develop atomic bombs, boosted fission bombs, ICBMs, and SLBMs to enhance its weapon capabilities. In addition, nuclear security crisis on the Korean Peninsula has been rising day by day as signs of restarting the North Korea’s Yongbyon 5MWe Graphite-moderated reactor were observed and the possibility of a seventh nuclear test have been increased. Since North Korea’s nuclear issue has a lot of influence on international security, especially on the Northeast Asian countries, a realistic denuclearization policy that reflects North Korea’s current domestic situation along with the international situation is needed. It’s been six months since Russia invaded Ukraine on February 24, 2022. The war between Russia, which has nuclear weapons, and Ukraine, which gave up its possession of nuclear weapons due to the Cooperative Threat Reduction (CTR) program known as the Nunn-Lugar program, is expected to have a significant impact on North Korea, which is considering denuclearization due to UN sanctions on North Korea. Therefore, in this study, based on the war patterns of Russia-Ukraine war, perspective on how it could affect North Korea’s denuclearization is analyzed. Also, significance and limitations of the previous nuclear negotiations, the North Korea’s political regime, the ‘five-year strategy for North Korea’s economic development’ and the ‘five-year plan for North Korea’s economic development’ were analyzed to suggest practical DPRK’s denuclearization policy.

Cordyceps militaris mycelium extracts containing high amounts of cordycepin were evaluated in vitro for their antiinflammatory and tumor cell growth-inhibitory activities. All extracts dose dependently inhibited the increased production of inflammatory mediators including reactive oxygen species (ROS), nitric oxide (NO), and β-hexosaminidase in lipopolysaccharide (LPS)-stimulated inflammatory cells. All extracts were evaluated for anti-proliferative activity against normal RBL-2H3 cells and diverse types of cancer cell lines, including HCT, MC5-7, U-87MG, AGS, and A549 cells. The extract showed the strongest growth inhibition (IC50 = 28.13 μg/mL) relative to vehicle-treated control cells against fibrosarcoma (MC5-7). We have demonstrated anti-inflammatory activity of C. militaris via inhibition of NO, ROS production, and β-hexosaminidase release in activated cells. C. militaris mycelium extract was also evaluated mechanistically and found to exert six types of anti-cancer activity, confirming its pharmacological potential. Our study suggests C. militaris use as a potential source of anti-inflammatory and anticancer agents. C. militaris may also be considered a functional food.

Store-operated Ca2+ entry (SOCE) represents one of the major Ca2+ entry routes in non-excitable cells. It is involved in a variety of fundamental biological processes and the maintenance of Ca2+ homeostasis. The Ca2+ releaseactivated Ca2+ (CRAC) channel consists of stromal interaction molecule and Orai; however, the role and action of Homer proteins as an adaptor protein to SOCE-mediated Ca2+ signaling through the activation of CRAC channels in non-excitable cells still remain unknown. In the present study, we investigated the role of Homer2 in the process of Ca2+ signaling induced by the interaction between CRACs and Homer2 proteins in non-excitable cells. The response to Ca2+ entry by thapsigargin-mediated Ca2+ store depletion remarkably decreased in pancreatic acinar cells of Homer2–/– mice, as compared to wild-type cells. It also showed critical differences in regulated patterns by the specific blockers of SOCE in pancreatic acinar cells of Homer2–/– mice. The response to Ca2+ entry by the depletion in Ca2+ store markedly increased in the cellular overexpression of Orai1 and STIM1 as compared to the overexpression of Homer2 in cells; however, this response was remarkably inhibited by the overexpression of Orai1, STIM1, and Homer2. These results suggest that Homer2 has a critical role in the regulatory action of SOCE activity and the interactions between CRAC channels.

Coal-based graphite has become the main material of emerging industries. The microstructure of coal-based graphite plays an important role in its applications in many fields. In this paper, the effect of carbon disulfide/N-methyl-2-pyrrolidone solvent mixture extraction on the microstructure of bituminous coal-based graphite was systematically studied through preliminary extraction coupled with high-temperature graphitization. The graphitization degree g (75.65%) of the coal residue-based graphite was significantly higher than that of the raw coal-based graphite. The crystallite size La of the coal residue-based graphite was reduced by 47.06% compared with the raw coal-based graphite. The ID/ IG value of the coal residue-based graphite is smaller than that of the raw coal-based graphite. The specific surface area (16.72 m2/ g) and total pore volume (0.0567 m3/ g) of the coal residue-based graphite are increased in varying degrees compared with the raw coal-based graphite. This study found a carbon source that can be used to prepare coal-based graphite with high graphitization degree. The results are expected to provide a theoretical basis for further clean and efficient utilization of the coal residue resources.

With the rapid improvement of hardware and software-related IT technology, applying A.I. to the private and public sectors, such as the Food Poisoning Prevention Program in Nevada and Smart City based on big data in Boston, is steadily increasing. However, the cases of application to the regulation sector of government are still insufficient. The Korea Institute of Nonproliferation and Control (KINAC) is studying to apply A.I. technology to the regulation to improve the objectivity, consistency, and efficiency of classification and export licensing review. The KINAC developed the Nation Nuclear Technology Information Collection and Analysis System using A.I. techniques such as machine learning and deep learning techniques. KINAC and FNC Technology are developing the Export Risk Assessment System using A.I. modules and Bayesian Networks. The KINAC and Korea Atomic Energy Research Institute (KAERI) are developing an inventory history management system subject to the Nuclear Cooperation Agreements. The Nuclear Safety and Security Commission (NSSC) and KINAC operate the Nuclear Import and Export Control System (NEPS) for application and export license review according to relevant laws such as the Foreign Trade Act. Therefore, preparing an integration plan for the existing NEPS and the new systems is necessary. Since the NEPS has to be operated and accessible at all times, so the stability of the NEPS is the most important when integration and linking. So, it is suggested that the Collection and Analysis System and the Risk Assessment System, which require a lot of data traffic, are configured in a server separate from the NEPS, and the new DB and the NEPS DB are only linked. An inventory history management system is also suggested to be integrated and configured into the NEPS. Third, it is recommended that each system lists the information provided to or received from the NEPS in advance, and one-way communication should be performed basically. Two-way communication should be performed when necessary. Finally, against various cyber accidents and information leakage, it is proposed to review security vulnerabilities and apply essential security measures and guidelines. Through the integration and linkage of these systems, it is expected that the objectivity, consistency, and efficiency of classification and export licensing review of the KINAC are strengthened, and national transparency of development, production, and use of nuclear material is enhanced. It can be satisfied with the increasingly strengthened demands of the international community on duty for strategic item management.

Meat affects color and quality by metabolite concentrations. Meat produces metabolites, and metabolites are caused by a variety of causes. Meat also produces metabolites by oxidation, which is an inevitable chemical process that meat undergoes which is resulting information of various chemical compounds. Thus, the aim of this study was to profiling the change of metabolites of M. longissimus lumborum during the storage at 4°C. Instrumental color measurements were showed decreasing chroma value, redness and yellowness (P<0.05) during storage, while non-significance (P>0.05) changes found in lightness value. Above all, hue angle was highest at 21 d of storage (P<0.05). The lipid and protein oxidation of muscles was measured by TBARS value significantly increased (P<0.05), thiol and carbonyl groups were also increased significantly (P<0.05) during the display. Total 19 of 60 identified compounds appeared to have a significant difference by storage time (P<0.05). Hue angle had a significant correlation with specific metabolites such as carbon disulfide, 3-methyl-1-butanol, 2-ethyl-1-hexanol, lactic acid and palmitic acid (P<0.05). Results of the current study provide the conversion of volatile and non-volatile metabolites and their correlation with oxidative indicators for changes in meat quality during aerobic storage.

Plant-derived compounds have been reported to possess anti-inflammatory abilities contained inhibited β-hexosaminidase, ROS and NO release. Essential oils are natural volatile complex compounds that are characterized by a strong scent and produced by aromatic plants as various plant-derived compounds. The essential oil extracted from Zanthoxylum coreanum Nakai (Z. coreanum) has various functional properties; however, little information is available regarding its anti-allergic inflammatory. A total of 17 compounds were detected in Z. coreanum oil, and the main component was estragole (50.86%). The tested Z. coreanum oil and estragole statistically inhibited the release of β-hexosaminidase induced by antigen stimulation in RBL-2H3 cells. This Z. coreanum oil and estragole may stimulate the secretion of active oxygen (ROS) or nitric oxide (NO) which are considered to involved in anti-inflammatory events. Moreover, it is suggested that Z. coreanum oil and estragole may negatively control the production of SNARE proteins (VAMP7) at the tran-scriptional and translational levels in common. These results demonstrate that Z. coreanum oil and its major component, estragole, possess potent anti-inflammatory abilities that are coupled with antioxidant properties.

Cordyceps militaris, a well-known traditional Chinese medicine, has multiple health-promoting effects. It is used as a herbal remedy and health food in Asian countries. Cultured mycelia are often used as a substitute for natural C. militaris. In the present study, the mycelia and fruiting bodies of artificially cultured C. militaris were analyzed using a metabolomics approach. The protein and crude fat contents of the mycelia were substantially higher than those of the fruiting bodies. The top three abundant amino acids in the mycelia were proline (3.9 g/100 g), aspartic acid (2.9 g/100 g), and glutamic acid (2.7 g/100 g). The carbohydrate content was similar in the fruiting bodies and mycelia. Analysis revealed that both the fruiting bodies and mycelia are rich in phenolic compounds and exhibit antioxidant activity. Further, six metabolites were significantly different between the mycelia and fruiting bodies. The levels of Ca, glucose, Mg, and Se were higher in the mycelia than in the fruiting bodies. In contrast, mannitol and Zn were more abundant in the fruiting bodies. The current study provides a comprehensive metabolic profile of the mycelia and fruiting bodies of artificially cultured C. militaris. Such an exercise is potentially important for understanding the metabolism of C. militaris and facilitating the use of cultured mycelia as a supplement to C. militaris fruiting bodies in traditional Chinese medicine.

Conductive carbon cloths (CCs) have been great attention as a promising current collector for flexible supercapacitors that supply power to portable and wearable electronics. However, the hydrophobic surface and weak adhesion with active materials has limited to be adopted as the binder-free and flexible electrode with mechanical/electrochemical stability. In this work, we demonstrate preparation of binder-free and flexible electrodes based on polyaniline (PANI) on carbon cloth. Polydopamine (PDA) layer are used to impart hydrophilicity, leading to uniform growth of PANI on the hydrophobic surface of carbon. Furthermore, PDA layer improves adhesion strength between PANI and carbon substrates, which allows for superior mechanical stability under ultrasonic condition. PANI-based flexible electrode shows high areal capacitance (160.8 mF cm− 2 at 0.5 mA cm− 2), good rate capability (71.1% even at high current density of 10 mA cm− 2), and long-term cycling stability (82.6% capacitance retention after 1500 cycles). Furthermore, a quasi-solid-state flexible supercapacitor reveals remarkable mechanical flexibility and durability, with superior capacitance retention (~ 100%) in bent state and after repetitive 1000 cycles.

Gabion was unfavorable to the reconstruction of the landscape caused by limit plant growth because of commonly filled with stone. Therefore, gabion was need substrate as possible to plant growth for harmonize with the surroundings and prevent of erosion. The objective of this study was to evaluate the effect of substrates based growing media containing wood meal on physical property (moisture content), chemical properties (organic matter and C/N ratio), plant cover and plant species in gabion. The substrates were composed of soil and soil mixed with growing media (9:1 (v/v) and 4:1 (v/v)). The growing media was prepared by mixing the basic materials, such as peat, perlite, with the specific materials, such as steam treated wood meal (Quercus mongolica) and NH4NO3. Field experiments were carried out on a damaged forest slope, South Korea, from January to November. The results, the moisture content of soil mixed with growing media (4:1, v/v) was maintained high value than others during the thermophilic period and consistently high organic matter which at an advantage for long term plant growth for 11 months. We were confirmed soil mixed with growing media (4:1, v/v) was an advantage to keep C/N ratio for plant growth period. The growing media based substrates has high plant cover percentage and advantage to plant growth for long term. And to conclude, in general the project is a success considering that few repairs or follow up will be necessary. This technique offers a solution to create a better harmony with the surrounding environment.

Predictive maintenance has been one of important applications of data science technology that creates a predictive model by collecting numerous data related to management targeted equipment. It does not predict equipment failure with just one or two signs, but quantifies and models numerous symptoms and historical data of actual failure. Statistical methods were used a lot in the past as this predictive maintenance method, but recently, many machine learning-based methods have been proposed. Such proposed machine learning-based methods are preferable in that they show more accurate prediction performance. However, with the exception of some learning models such as decision tree-based models, it is very difficult to explicitly know the structure of learning models (Black-Box Model) and to explain to what extent certain attributes (features or variables) of the learning model affected the prediction results. To overcome this problem, a recently proposed study is an explainable artificial intelligence (AI). It is a methodology that makes it easy for users to understand and trust the results of machine learning-based learning models. In this paper, we propose an explainable AI method to further enhance the explanatory power of the existing learning model by targeting the previously proposedpredictive model [5] that learned data from a core facility (Hyper Compressor) of a domestic chemical plant that produces polyethylene. The ensemble prediction model, which is a black box model, wasconverted to a white box model using the Explainable AI. The proposed methodology explains the direction of control for the major features in the failure prediction results through the Explainable AI. Through this methodology, it is possible to flexibly replace the timing of maintenance of the machine and supply and demand of parts, and to improve the efficiency of the facility operation through proper pre-control.