Lupus anticoagulant-hypoprothrombinemia syndrome (LAHS) is a rare disease associated with lupus anticoagulant and factor II deficiency. LAHS is usually associated with autoimmune disease or with transient viral infection. A 27-month-old boy had a gross hematuria. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were markedly prolonged. The aPTT was not corrected after mixing with normal plasma. The level of factor II was decreased. Diluted Russell's viper venom test demonstrated the lupus anticoagulant. He was diagnosed with LAHS. His clinical symptom was improving without medical treatment. Serial laboratory studies showed that PT, aPTT, and factor II level were normalized.

The primary objective of this study was to determine the effects of abalone in reducing blood pressure and increasing anti-coagulant capacity. The serum angiotensin-converting-enzyme (ACE) activities of rats on an abalone-supplemented diet did not significantly differ from the ACE levels of rats on a normal diet, at any time (before the experiment, or 1 week, 2 weeks, 3 weeks, and 4 weeks, after commencement of the abalone diet) during the experiment. This result showed that abalone-supplemented diets had no effect on the activity of ACE, which controls blood pressure. To determine if an abalone-containing diet might increase anti-coagulant capacity, both prothrombin (PT) and activated partial thromboplastin time (APTT) levels were measured. The PT levels of control rats remained constant throughout the experiment. In rats fed the abalone-containing diet, PT levels increased with time, and the increase became statistically significant after 2 weeks, when compared to pre-trial PT levels. Control rats showed no significant change in APTT levels over time. The rats fed abalone, however, showed significant differences in APTT levels. Specifically, when pre-trial APTT levels were compared with 4-week levels, and when 1-week levels were compared with 4-week levels, the differences attained statistical significance. These results indicate that an abalone-supplemented diet may inhibit blood coagulation in normal rats. The results of this study prove the inherent health value of abalone, and may encourage investment in the seafood industry. Future studies will explore other possible beneficial effects of abalone, apart from the anti-hypertension and anti-coagulant effects examined above.