This study explored the potential of cocoa bean husk, a by-product of cocoa processing, as a functional food ingredient. It evaluated how extraction conditions and solvent fractionation affect the content of phenolic compounds and their antidiabetic activity. Cocoa bean husk was extracted using varying concentrations of ethanol (0%, 50%, 70%, and 99%), and the total polyphenol and flavonoid contents were measured alongside the inhibitory activities against α-glucosidase and α-amylase. The extract using 70% ethanol yielded the highest levels of total polyphenols and flavonoids, as well as the strongest inhibitory effects on both enzymes. These findings suggest that aqueous ethanol is more effective than absolute ethanol in extracting bioactive compounds from cocoa bean husk. Following this, the 70% ethanol extract was further fractionated; among the fractions, the ethyl acetate and butanol fractions had the highest total polyphenol and flavonoid contents. Notably, the butanol fraction demonstrated the most significant antidiabetic activity, showing the lowest IC₅₀ values for inhibiting α-glucosidase and α-amylase. This indicates that antidiabetic activity is influenced not only by the total phenolic content but also by the qualitative composition and structural characteristics of the phenolic compounds. Overall, cocoa bean husk shows considerable promise as a value-added functional food ingredient with antidiabetic properties.

This study was done to investigate the antidiabetic and antioxidant effects of Cibotium barometz in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose 45㎎/㎏.b.w. dissolved in citrate buffer(pH4.5). The ethanol extract of Cibotium barometz was orally administrated once a day for 7 days. The contents of serum glucose, triglyceride(TG) and total cholesterol were significantly decreased(p<0.05) in Cibotium barometz treated group compared to the those of STZ-control group, The content of glutathione(GSH) and activity of gluthathione-s-transferase(GST) were significantly increased (P<0.05) in Cibotium barometz treated group compared to the those of STZ-control group. andactivityes of catalase(CAT) and glutathione peroxidae(GSH-Px) were signiicantly decreased (P<0.05) in Cibotium barometz treated group compared to the those of STZ-control group. Also the content of hepatic glycogen and activities of glucose-phosphate dehydrogenase(G-6-PDH)and glucokinase(GK) were significamtly increased(p<0.05), but activity of glucose-6-phosphatase (G-6-Pase) was significamtly decreased (p<0.05) in Cibotium barometz treated group compared to the those of STZ-control group. These results indicated that ethanol extract of Cibotium barometz would have antidiabetic and antioxidant effects in STZ-induced diabetic rats.

This study was done to investigate the antidiabetic and antioxidant effects of Lycii fructus in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose 45mg/kg.b.w. dissolved in citrate buffer(pH4.5). The ethanol extract of Lycii fructus was orally administrated once a day for 7 days. The contents of serum glucose, total cholesterol were significantly decreaed (p<0.05) in Lycii fructus treated group compared to the those of STZ-control group, also content of Triglyceride (TG), Altherogenic index (AI) were decreased, but not statistically significant. But high density lipoprotein (HDL)-cholesterol and HDL-cholesterol/total cholesterol ratio (HTR) were increased in Lycii fructus treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(G-6PDH), glutathione-s-transferase(GST), superoxide dismutase(SOD) were significantly increased(p<0.05), glucose-6-phos-phatase(G-6pase)was significantly decreased(p<0.05) and The glutathione(GSH), glucokinase(GK) were increased. But not statistically significant In Lycii fructus treated group compared to the those of STZ-control group These results indicated that ethanol extract of Lycii fructus would have antidiabetic and antioxidant effects in STZ-induced diabetic rats.

The extraction yield of Corni fructus was about 47.5% by extract apparatus. This study was done to investigate the antidiabetic and antioxidative effects of Corni fructus in Streptozotocin (STZ)-induced diabetic rats. The contents of serum glucose, total cholesterol and hepatic lipid peroxide, glutathione were significantly decreaed (p<0.05) in Corni fructus treated group compared to the those of STZ-control group, also content of triglyceride (TG), atherogenic index (AI) and activity of catalase were decreased, but not statistically significant. High density lipoprotein (HDL)-cholesterol and HDL-cholesterol/total cholesterol ratio (HTR) were increased in Corni fructus treated group compared to the those of STZ-control group. The activities of glutathione-S-transferase (GST) and superoxide dismutase (SOD) were significantly decreaed (p<0.05) in Corni fructus treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-phosphate dehydrogenase (G-6 PDH), glucokin-ase were significantly increased, but activity of glucose-Grphosphatase (G-6 Pase)was decreased in Corni fructus treated group compared to the those of STZ-control group. Therefore, these results indicated that ethanol extract of Corni fructus would have antidiabetic and antioxidative effects in STZ-induced diabetic rats.

본 연구는 당뇨처방을 근거로 구성된 생약재 복합물의 항당뇨 효능을 조사하기 위하여 복합물의 인슐린성 물질을 탐색하고 -amylase 및 -glucosidase 저해활성을 평가하였다. 3T3-L1 세포에 복합 생약재 추출물을 의 농도로 처리하였을 때 지방세포로의 분화능은 151.7%로 인슐린의 작용을 향상시키는 것으로 확인되었다. 혈당저하제로서 생약재 복합 추출물의 -amylase에 대한 저해활성은 생약재 복합 추출물 10.0, 1.0 및 0.1