최근에는 스마트폰 중독의 ‘저연령화’가 우려된다. 아동의 스마트폰 중독에 영향을 미치는 요인은 아동의 개인적 특성 뿐만 아니라 부모요인이 있다. 아동의 스마트폰 중독에는 부모양육태도가 중요하게 영향을 미친다. 본 연구는 아동의 스마트폰 중독 경향에 대한 부모의 양육태도와 아동의 주의집중 문제의 구조모형을 분석하였다. 한국청소년정책연구원에서 제공한 한국아동청소년 패널조사(KCYPS 2018)의 중 초등학교 4학년의 자료를 사용하였다. 자료 분석은 SPSS 24.0과 AMOS 24.0을 사용하여 Pearson 상관분석, 구조방정식 모형을 분석하였다.

Spermatogonial stem cells are self-renewal and differentiate into sperm in post-pubertal mammals. There exists a balance between the self-renewal and differentiation in the testes. Spermatogonial stem cells make up only 0.03% of testicular cells in adult mice. These cells maintain sperm production by differentiating after puberty. Therefore, analyzing the expression of genes associated with spermatogenesis is critical for understanding differentiation. The present study aimed to establish the postnatal period of cells in relation to spermatogenesis. To study the expression of differentiated and undifferentiated marker genes in enriched spermatogonial stem cells, in vitro culture was performed and cells from pup (6–8-day-old) and adult (4-months-old) testicular tissues were isolated. As a result, undifferentiated genes, Pax7, Plzf, GFRa1, Etv5 and Bcl6b , were highly increased in cultured spermaotogonial stem cells compared with pup and adult testicular cells. On the other hands, differentiated gene, c-kit was highly increased in adult testicular cells, Also Stra8 gene was highly increased in pup and adult testicular cells. This study provides a better understanding of spermatogenesis-associated gene expression during postnatal periods.

최근에는 청소년의 스마트폰 사용이 현저하게 증가하고 스마트폰 과의존과 중독적 사용이 문제가 되고 있다. 스마트폰 이용에 대한 조절력이 감소함으로써 문제적 결과를 경험하게 되는 상태를 스마트폰 과의존이다. 본 연구는 중학생을 대상으로 스마트폰 의존이 청소년의 친구관계에 미치는 영향에서 정서적 문제의 매개효과를 살펴보았다. 한국청소년정책연구원의 한국아동청소년 패널조사(KCYPS 2018)를 활용하였다. 중학교 1학년 코호트 자료를 사용하였으며, 연구대상은 총 2,590명이다. 자료분석을 위해 SPSS 24.0과 AMOS 25.0을 활용하여 Pearson 상관분석, 구조방정식 모형 분석을 실시하였다.

This study suggested methods of intervention for juvenile game addiction based on literature studies on brain plasticity and addiction and application of arts therapy techniques. First, it provides repetitive experiences through art therapy. When the frequency of use of a specific synapse changes due to repeated experiences, the synapse adapts to the changed positive environment by changing and controlling its structure and function. Synaptic plasticity through repetitive experiences causes the mind to re-regulate the brain. Second, art therapy activities based on the youth's environment and experiences are applied. Art therapy changes the brain through the development of new neural networks. It incorporates the physical, emotional, and cognitive functions of adolescents by accepting the integrated nature of art and psychotherapy. Third, creative art therapy finds an activity that can effectively approach an individual's positive sensory experience and repeats it to control the overwhelmed emotion. There is an effect of activating self-healing through activities that repeat the experiences that give game addiction adolescents now-here (present) pleasure.

In this paper, the model for predicting yields of chinese cabbages of each cultivar (joined-up in 2015 and wrapped-up in 2016) was developed after the reflectance of hyperspectral imagery was merged as 10 nm, 25 nm and 50 nm of FWHM (full width at half maximum). Band rationing was employed to minimize the unstable reflectance of multi-temporal hyperspectral imagery. The stepwise analysis was employed to select key band ratios to predict yields in all cultivars. The key band ratios selected for each of FWHM were used to develop the yield prediction models of chinese cabbage for all cultivars (joined-up & wrapped-up) and each cultivar (joined-up, wrapped-up). Effective accumulated temperature (EAT) was added in the models to evaluate its improvement of performances. In all models, the performance of models was improved with adding of EAT. The models with EAT for each of FWHM showed the predictability of yields in all cultivars as R2≥0.80, RMSE≤694 g/plant and RE≤28.3%. Such as this result, if the yield can be predicted regardless of the cultivar, it is considered to be advantageous when predicting the yield over a wide area because it is not require a cultivar classification work as pre-processing in imagery.

Recently, studies have been actively conducted on seismic design and improvement of the seismic performance of bridges, buildings, factories, and plants. In particular, heavy items that are being manufactured or waiting to be shipped from factories (such as generators, engines, and boilers) must be equipped with seismic stoppers to prevent them from moving or falling during an earthquake. Seismic stoppers should be suitably determined by the size and weight of these heavy items; however, they have no general design standard. In this study, structural analyses and seismic tests were conducted to evaluate the performance of newly designed seismic stoppers. Structural analysis was performed on three stopper models to estimate the external load at which the yield stress of the material was not exceeded. Based on the analysis results, a seismic test of the stopper was carried out in accordance with the AC156 test method. Finally, product specifications for all three seismic stopper models were determined and their static/dynamic load performance was evaluated.

In this study, we investigated the relationships between benthic macroinvertebrate assemblages and various environmental factors in Iancheon (NIA) and Bukcheon (NBC) streams, Korea. We collected benthic macroinvertebrates and 33 environmental factors in April 2017 at 9 sites (5 sites in NIA and 4 sites in NBC). We identified 93 species (5 phyla, 9 classes, 16 orders, and 53 families) and 69 species (5 phyla, 9 classes, 17 orders, and 47 families) in NIA and NBC streams, respectively. Considering benthic macroinvertebrate index (BMI), NIA (88.2) and NBC (80.2) streams were in “very good” status. Upstream areas showed the highest scores, 95.5 (NIA1) and 94.2 (NBC1), whereas BMI score was the lowest in downstream areas of both streams, especially in NBC4 (51.0 “bad” status). Cluster analysis and non-metric multidimensional scaling analysis represented the differences of benthic macroinvertebrate assemblages according to spatial and anthropogenic gradients. Our findings provide reference data and highlight the need for the continued monitoring to maintain the good status and manage macroinvertebrate diversity in these two streams, in Sangju-si, Korea.

목적 : 여러 분자량의 polyethylene glycols(PEGs)을 화학적 공유결합으로 하이드로겔 콘택트렌즈 표면에 고정 시켰다. PEG의 도입이 렌즈의 표면 습윤성, 단백질 흡착성, 광투과율 등에 미치는 영향을 PEG의 길이 혹은 PEG 의 적용여부 등에 초점을 맞추어 분석하는데 실험 목적이 있다. 방법 : PEG에 Jones oxidation 반응을 통해 알코올기를 카르복실 작용기로 변형시켰고, 하이드로겔 콘택트렌즈 표면에 화학적으로 결합시켰다. 역상 고성능 크로마토그래피와 단백질 표준검량선을 이용하여 제조된 렌즈들에 흡착된 단백질을 정량하였다. 결과 : PEG가 개질된 하이드로젤 콘택트렌즈는 우수한 광투과율과 표면 습윤성을 보였고 이는 상업적으로 이용가능한 수치이다. 단백질 흡착 실험 결과를 살펴보면, 보단 긴 PEG 사슬이 적용된 하이드로겔 콘택트렌즈는 표면 친수성이 더 우수하기 때문에 단백질 흡착량이 더욱 감소하였다. 결론 : 본 연구에서는 PEG가 표면-개질된 하이드로겔 콘택트렌즈를 제조하고 이들의 물성을 조사하였다. PEG 각 적용된 렌즈는 90% 이상의 광투과율과 개선된 표면 습윤성을 보여주었다. 특히, 보다 긴 PEG2000이 적용된 렌즈에는 PEG가 적용되지 않은 대조군이나 짧은 PEG164가 적용된 렌즈 보다 단백질의 흡착이 크게 감소되었다. PEG가 표면에 적용된 하이드로겔의 제조는 안의료용 바이오소재 뿐만 아니라 단백질-비흡착 기기의 개발에 큰 역할을 할 것으로 기대된다.

Periodontitis is an inflammatory disease of the supportive tissues surrounding the teeth, and is characterized by irreversible destruction of the gingiva, periodontal ligament (PDL), and alveolar bone, which results in the loss of teeth. In the present study, we elucidated the correlation between periodontitis and apelin (APLN), an adipokine and a regulatory peptide, respectively, which are involved in inflammation and bone remodeling. The expression of APLN is negatively correlated with periodontitis progression in gingival tissue. In addition, treatment with TNF-α downregulated the expression of APLN in PDL cells and gingival fibroblasts, indicating the protective role played by APLN against periodontitis progression. The overexpression of APLN or treatment with exogenous APLN suppressed the TNF-α- mediated catabolic gene expression of MMP1, IL6 , and PTGS2 in PDL cells. Moreover, the inhibition of the APLNAPJ axis by ML221, an APJ inhibitor, induced catabolic gene expression in PDL cells. Thus, the results of this study provided evidence to support APLN as a regulatory factor of the inflammatory response during periodontitis.