Two dogs presented with nodular masses on the head and scapula. The masses recurred after excision and were submitted for histopathological examination. Macroscopically, hemorrhage and necrosis were apparent on the cut surface. Microscopically, the lesions were poorly demarcated and incorporated subcutaneous fat and adjacent skeletal muscle fibers. Fibrocytes and fibroblasts were admixed and haphazardly arranged. Both were diagnosed with nodular fasciitis (NF). NF has been rarely reported and called as a ‘pseudosarcomatous’ lesion because of its infiltrative growth and cellular pleomorphism. The present report describes unusual cases of recurrent NF in two young dogs based on histopathologic and clinical features.

Celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, was approved as a non-steroidal anti-inflammatory drug (NSAID), and this therapeutic application has been expanded to several other diseases, including colon cancer. Notably, a treatment strategy combining the use of celecoxib and radiation therapy has been employed for improving the control of local cancers. In this study, we examined the effect of celecoxib on irradiation-induced intestinal damage. The twenty four mice (BALB/c) were divided into four groups; 1) sham-irradiated control group, 2) celecoxib-treated group, 3) irradiated group, and 4) celecoxib-treated irradiation group. Mice were orally administered celecoxib at a dose of 25 mg/kg in a 0.1 mL volume, daily for 4 days after irradiation exposure (10 Gy). Then, histological examinations of the jejunal villous height, crypt survival, and crypt size were performed. The expression of COX-2 after administration of celecoxib in irradiated mice was examined by employing immunohistochemistry, Western blotting, and qPCR analysis. The jejunal villi height and the crypt survival were reduced in the irradiation group compared with the sham-irradiated group. Celecoxib treatment in irradiation mice even more decreased those indicators. Crypt size was increased in the radiation group compared to the sham-irradiated control group, whereas the size was decreased in the celecoxibtreated irradiation group compared with the group exposed to the radiation injury. COX-2 expression was detected in the crypt of the small intestine, and COX-2 expression was increased in the crypt lesion following radiation exposure. However, COX-2 expression was reduced in the celecoxib-treated irradiation group. Therefore, in the present study, we confirmed that celecoxib treatment after irradiation aggravated the irradiation-induced intestinal damage. These results suggest that a caution need to be administered when celecoxib treatment is performed in combination with radiation therapy for cancer treatment.

혁신은 특히 신흥국가 시장에 속한 기업들에게 도전적인 일이다. 5% 이상 지분을 소유한 소위 블록 기관투자자는 기업 혁신에 있어 중요한 역할을 맡고 있다. 본 연구는 중국 증시에 상장된 기 업들을 표본으로 블록 기관투자자들이 기업혁신의 성과에 미치는 영향을 분석하였다. 주요 연구자 료로서 기업이 허가받은 발명 특허의 건수를 사용하여 기업혁신의 성과를 측정하였다. 2007년부터 2016년까지 1,126개 중국 기업의 패널 데이터를 사용하여 분석한 결과, 블록 기관투자자는 기업 경영에 대해 적극적인 모니터링을 수행하며, 경영진의 커리어 우려를 해소시킴으로써 기업의 혁신 성과에 긍정적인 영향을 미치고 있음을 발견하였다. 어떤 유형의 블록 기관투자자가 보다 유의한 영향을 미치는지를 분석하기 위하여 기관투자자의 국적과 투자기간에 따라 블록 기관투자자를 국 내 블록 기관투자자와 해외 블록 기관투자자, 그리고 장기적 블록 기관투자자와 단기적 블록 기관 투자자로 구분하였다. 실증분석 결과, 국내 및 해외의 블록 기관투자자는 모두 중국기업의 혁신 성 과에 유의하게 긍정적인 영향을 미치고 있었다. 특히 해외의 장기적인 블록 기관투자자의 긍정적인 영향이 가장 크게 나타났다. 반면에 단기적인 블록 기관투자자가 혁신 성과에 미치는 영향은 통계 적으로 유의하지 않았다. 이런 분석 결과들은 강건성 테스트에서도 일치하게 나타났다.

Continuous synthesis of high-crystalline carbon nanotubes (CNTs) is achieved by reconfiguring the injection part in the reactor that is used in the floating catalyst chemical vapor deposition (FC-CVD) process. The degree of gas mixing is divided into three cases by adjusting the configuration of the injection part: Case 1: most-delayed gas mixing (reference experiment), Case 2: earlier gas mixing than Case 1, Case 3: earliest gas mixing. The optimal synthesis condition is obtained using design of experiment (DOE) in the design of Case 1, and then is applied to the other cases to compare the synthesis results. In all cases, the experiments are performed by varying the timing of gas mixing while keeping the synthesis conditions constant. Production rate (Case 1: 0.63 mg/min, Case 2: 0.68 mg/min, Case 3: 1.29 mg/min) and carbon content (Case 1: 39.6 wt%, Case 2: 57.1 wt%, Case 3: 71.6 wt%) increase as the gas-mixing level increases. The amount of by-products decreases stepwise as the gas-mixing level increases. The IG/ID ratio increases by a factor of 7 from 10.3 (Case 1) to 71.7 (Case 3) as the gas-mixing level increases; a high ratio indicates high-crystalline CNTs. The radial breathing mode (RBM) peak of Raman spectrograph is the narrowest and sharpest in Case 3; this result suggests that the diameter of the synthesized CNTs is the most uniform in Case 3. This study demonstrates the importance of configuration of the injection part of the reactor for CNT synthesis using FC-CVD.

이 논문의 목적은 현대 영미 시인에게서는 찾아보기 어려운 ‘윤리적 시각’을 히니가 추구하고 있음을 그의 시 전체를 읽어서 증명하는 것이다. 여기서 언급한 ‘윤리적 시각’의 의미는 자신의 부모, 국토 그리고 공동체의 문화라는 그 뿌리와 ‘타자’ 나아가 영혼에 대한 사랑과 책임감인 것이다. 한편 히니의 시적 발전 단계는 겔트, 게일릭 전통을 추구하는 초기 시, 아일랜드와 영국 미국, 유럽적 가치가 공존하는 글로컬리즘을 추구하는 중기 시, 그리고 아일랜드의 정신적 뿌리인 ‘이시누쿠’를 추구하는 후기 시의 세 단계로 구분된다. 그런데 각 시적 발전 단계에다 다음과 같은 이유로 ‘윤리적’이란 말을 적용시킬 수 있다, 초기 시에는 그가 성장한 배경인 민속 문화와 고난의 역사 속에서 생존한 선조와 부모에 대한 작가의 연민과 책임 정신이 표현되었고, 중기 시에는 자신과 자신이 속한 공동체를 객관적으로 비판하고 그 공동체를 대변하지 못 했음에 죄의식을 느끼면서 다른 한편으로는 ‘차이’를 수용하려는 균형 잡힌 정신이 반영되고 있기 때문이다. 그리고 후기 시에서는 화해와 심미 정신을 바탕으로 한 숨겨진 아일랜드의 정신을 추구하기 때문이다.

Objective: The Modified Barthel Index (MBI) measures individuals’ level of independence in performing activities of daily living. The purpose of this study was to examine the internal consistency and construct validity of the MBI for children with rare disorders. Methods: The study participants are children with rare disorders who have muscle weakness including Barth syndrome and congenital muscular dystrophy (N = 113). The MBI was completed by participants in either an online format utilizing the UF Qualtrics system or a pencil-and-paper format. Statistical analysis was conducted to examine the psychometric properties of the MBI. Results: The MBI showed excellent internal consistency for children with Barth syndrome (Cronbach’s α = .91) and congenital muscular dystrophy (Cronbach’s α = .93). Construct validity was supported by a significant difference in MBI scores among participants grouped by diagnoses. MBI score was significantly different between the unaffected group and congenital muscular dystrophy (p < .0001) as well as between the unaffected group and Barth syndrome (p < .0001). Conclusion: The psychometric properties of the MBI present good reliability and construct validity suggesting suitability for use as an outcome measure for children with rare disorders.