ZrO2 is a candidate material for hip and knee joint replacements because of its excellent combination of biocompatibility, corrosion resistance and low density. However, the drawback of pure ZrO2 is a low fracture toughness at room temperature. One of the most obvious tactics to cope with this problem is to fabricate a nanostructured composite material. Nanomaterials can be produced with improved mechanical properties(hardness and fracture toughness). The high-frequency induction heated sintering method takes advantage of simultaneously applying induced current and mechanical pressure during sintering. As a result, nanostructured materials can be achieved within very short time. In this study, W and ZrO2 nanopowders are mechanochemically synthesized from WO3 and Zr powders according to the reaction(WO3 + 3/2 Zr→W+ 3/2 ZrO2). The milled powders are then sintered using high-frequency induction heating within two minutes under the uniaxial pressure of 80MPa. The average fracture toughness and hardness of the nanostructured W-3/2 ZrO2 composite sintered at 1300oC are 540 kg/mm2 and 5 MPa·m1/2, respectively. The fracture toughness of the composite is higher than that of monolithic ZrO2. The phase and microstructure of the composite is also investigated by XRD and FE-SEM.

Oxidative stress is one of common cause of fatty changes in the liver. Antioxidant capacity was confirmed in various vegetables including black radish (Raphanus sativus L. var niger). Fermentation of vegetables using Lactobacillus plantarum has been known to generate bioactive components. This study was conducted to determine if fermented black radish (FBR) ameliorates oxidative liver injury induced by CCl4 in rats. To accomplish this, FBR (250 and 500 mg/ kg) was orally administered to rats for 7 consecutive days, single CCl4 (1.5 mL/kg) treatment or no treatment orally. Serum chemistry at 24 hours after CCl4 injury showed that FBR (500 mg/kg) significantly reduced the level of both alanine aminotransferase and aspartate aminotransferase in CCl4 exposed rats. Moreover, FBR treatment significantly increased radical-scavenging effects in livers with the reduction of lipid peroxidation in CCl4 exposed rats. Histopathologic findings including Kupffer cell activation in the liver of each group matched those of serum chemistry. Collectively, black radish, through fermentation, exerts hepatoprotective capacity in CCl4 induced liver injury in rats through anti-oxidation.

In present study, we investigated the antidiabetic effect of Momordica charantia(as well known “bitter melon”). This study was conducted to determine antidiabetic mechanism of Bitter Melon Extract (BME). We measured blood glucose, insulin, glucagon level in a Sprague-Dawley rat model of high-fat diet/streptozotocin(HFD/STZ)-induced diabetes. Five experimental groups were used: normal, HFD/STZ, BME 62.5 mg/kg HFD/STZ, BME 125 mg/kg HFD/STZ and BME 250 mg/kg HFD/STZ. BME was orally administered to the rats every other day for 9 weeks. Results showed that fasting blood glucose levels were significantly lower in the BME 125 mg/kg(150.17 ± 20.22 mg/dL) and 250 mg/kg(124.17 ± 22.17 mg/dL) groups than in the vehicle group(188.83 ± 26.63 mg/dL)(p<0.05). In addition, glucagon levels were lower in the three BME treatment groups than in the vehicle group(p<0.05). Oral glucose tolerance tests revealed that the BME 250 mg/kg group had significantly(p<0.05) reduced 120-minute blood glucose levels and areas under the curve. Our results suggest that BME induces antidiabetic effects via the reduction of glucagon and blood glucose levels.

본 연구는 전단력과 휨을 받는 춤이 작은 중공 SFRC 부재를 대상으로 중공에 따른 웨브폭이 부재의 전단강도에 미치는 영향을 평가하고자 실험 및 해석을 실시하고 기존식과 비교⋅분석하였다. 전체폭에 비하여 웨브폭은 1/2배, 2/3배로 선정하였으며, 전단경간비는 1.5로 계획하였다. 전단실험 결과, 웨브폭이 33% 증가함에 따라 최대전단강도는 10.3~28.0% 증가하였다. 실험체의 전체춤이 1.5배 증가함에 웨브폭이 100mm인 실험체는 전단강도가 29.2% 증가한 반면, 150mm인 실험체는 11.3% 증가에 그쳐, 웨브폭이 적을수록 춤의 증가에 따른 전단강도 증가율이 큰 것으로 나타났다. 이를 볼 때, 웨브폭이 적을수록 강섬유의 기여도가 큰 것으로 사료된다. KCI 기준식이 중공 슬래브의 전단강도를 매우 안전측으로 평가하고 있으며, Shin et al.의 제안식이 실험강도를 비교적 잘 예측하는 것으로 나타났다. 비선형 유한요소 해석으로부터 웨브폭이 2, 3, 6배 증가함에 따라 해석부재의 평균 전단강도는 각각 1.18배, 1.80배, 2.19배로 나타나, 웨브폭의 증가에 비례하여 전단강도가 증가하지 않는 것으로 나타났다.

This study was carried out to compare the major volatile components in essential oil from different origin of Atractylodes spp. which is being traded as a crude herbal drug in Korean herbal markets. From the two Atractylodes of major volatile components were similarly detected such as the β-selinene, β-sesquiphellandrene, germacrene B, 2,7-dimethoxy-2-methylnaphthalene and 9-methoxy-2,3-dihydrofuro3,2-qcoumarin. Among the volatile components, the major components were 2,7-dimethoxy-2-methylnaphthalene (40.98%), 9-methoxy-2,3-dihydrofuro 3,2-q coumarin (15.74%), and β-sesquiphellandrene (1.98%) in both Atractylodes. As a results, It was found that the two Atractylodes were the same species which was being traded in the Korean herbal markets as the A. japonica. not to different species of A. japonica and A. macrocephalla, respectively.