본 연구는 한반도 유사 사례 중 하나인 1976년 판문점 도끼 사건에 대 한 한미일 3국의 관점을 역사적인 측면에서 관련 문서를 통해 고찰하였 다. 한국 정부와 국회는 북한과 공산주의에 관한 강렬한 적대감을 나타내 었다. 미국 백악관도 북한의 전적인 책임을 강조하며 북한을 비난하였다. 미국 의회는 판문점 도끼 사건을 규탄하였지만, 동시에 한국의 국내 인권 문제에 대해서도 논하였다. 이에 박정희 정권은 미국 의회의 대응이 매우 모호하다고 판단하여 불편함을 나타내며 미국 국무부에 도움을 요청하였 다. 한편, 일본 정부와 자민당은 판문점 도끼 사건에 대한 미국의 초기 대응에 공감하였다. 그러나 일본 국회에서 다른 정당은 한반도 유사시 미 국의 동맹인 일본이 개입하게 될 가능성을 매우 우려하였다. 본 연구는 한반도 유사 사례 중 하나인 1976년 판문점 도끼 사건이 발생하였던 당 시 한미일 3국의 시각이 모두 협력적이지는 않았음을 강조한다.

본 연구는 담액수경재배(Deep Flow Technique, DFT)로 재배된 잎들깨(Perilla frutescens)의 생장 및 생리 적 반응에 미치는 인산결핍의 영향을 분석하였다. 인산 결핍 처리는 야마자키 표준 배양액을 수정하여 0% (대조 구), 30%, 50%, 70%, 100%의 5 수준으로 달리 조성하였다. 처리 20일부터 80일까지 인산 결핍 수준이 증가함에 따라 초장, 엽수, 마디 수, 경직경이 유의미하게 감소하였다. 80일째에는 100% 인산 결핍 처리에서 초장이 10.1cm, 엽수는 식물체당 2.7장으로 급감하였으며, 이는 대조구의 73.5cm 및 12.8장에 비해 현저한 생장 저해를 나타냈다. 또한, 인산 결핍 조건에서 생체중과 건물중 모두 현저히 감소하였으며, 대조구의 생체중은 93.4g 이었으나 100% 인산결핍 처리구에서는 2.1g으로, 건물중은 11.8g에서 0.4g으로 크게 감소하였다. 인산 결핍 정도가 증가할수록 하 부엽에서 황화(Chlorosis) 및 괴사(Necrosis)와 같은 생리장해 증상이 뚜렷하게 나타났다. 이러한 결과는 인산이 잎 들깨의 영양생장과 건물생산량 증가에 필수적인 역할을 수행함을 나타내었다.

본 논문은 한반도 유사 사례 중 하나인 KAL 858 사건 당시 한미일의 대응을 검토하였다. 본 연구는 KAL 858 사건이 발생했던 전두환 정권 시기와 노태우가 대통령으로 취임했던 1988년 2월 25일 이후 시기를 구 분하여 한국, 미국, 일본에서 생산된 1차 자료들을 중심으로 검토하였다. KAL 858 사건 발생 당시 한국, 미국, 일본은 공통적인 반응을 나타냈 다. 우선 KAL 858 사건이 일어났던 1987년 11월부터 한국, 미국, 일본 모두 협력하여 북한을 규탄하며 제재를 가하였다. 반면, 노태우 대통령 취임 이후 한국, 미국, 일본은 북한을 규탄하면서도 군사적인 보복 등의 강력한 제재와 관련된 고려를 줄였다. 본 연구는 1987년 KAL 858 사건 에서 한국, 미국, 일본이 협력하는 모습을 보였음을 제시한다.

Gentamicin is an aminoglycoside antibiotic effective against aerobic gram-negative bacteria and is also used in veterinary medicine, particularly in the swine and bovine industries. However, no gentamicin product is currently approved for treating equine diseases in Korea. The present study aims to examine the time-dependent residue of gentamicin in horses after intravenous injection (IV) via jugular vein. The test product was injected at 6.6 mg/kg BW via jugular vein in nine horses. Blood was collected from the horse's jugular vein at 15 minutes, 30 minutes, 1, 4, 8, 12, 24 and 48 hours after injection. To purify the gentamicin in serum, 100μL of 20 mM HFBA in DW, 100 μL of 30% trichloroacetic acid and 300 μL of 20 mM heptafluorobutyric acid (HFBA) in acetonitrile (ACN) were added to 500 μL of serum and supernatant was applied to LC-MS/MS after centrifugation. LC-MS/MS-8050 analyzed the level of gentamicin in serum with Electrospray ionization (ESI) and multiple reaction monitoring (MRM) positive mode. Gentamicin C1 was 478 m/z and product ions were 322, 157 m/z. Precursor ion of Gentamicin C1a was 450 m/z and product ions were 322, 160 m/z. Precursor ion of Gentamicin C2 and C2a was 464 m/z and product ions were 322, 160 m/z. The LC column was a C18 and mobile phase composed of 20 mM HFBA in 5% ACN and 20 mM HFBA in 50% ACN. The amount of gentamicin was calculated by adding four components of gentamicin (C1, C1a, C2 and C2a). The pharmacokinetic parameters of gentamicin were calculated by the WinNonlin program. The Cmax of gentamicin in horse serum was 93 ± 17 μg/kg and the Tmax was 0.25 ± 0 hours. The T1/2 was 6.41 ± 2.32 hours and the CLt was 0.05 ± 0.01L/hr/kg. The Vd was shown as 0.44 ± 0.13 L/kg and the MRT was 1.98 ± 0.55 hours. In conclusion, our data provides useful pharmacokinetic parameters for gentamicin in horses following IV injection.

본 연구는 딥러닝 영상 재구성 기법을 적용한 8개의 뇌질환군의 감마나이프 수술 계획용 자기공명영상(magnetic resonance imaging, MRI)의 유용성을 알아보고자 하였다. 연구 방법은 전이성 뇌종양, 뇌동정맥 기형, 수막종, 뇌하수체선종, 삼차신경통, 청신경초종, 맥락얼기 유두종, 해면상 혈관종, 총 8개의 질병을 진단받은 사람들의 T2 강조 영상(T2 weighted imaging, T2WI), 조영증강 T1 강조영상(contrast enhancement T1 weighted imaging, CE-T1WI)의 방법으로 검사한 MRI 영상을 SwiftMR을 이용하여 딥러닝 영상 재구성 기법인 디노이징(denoising)과 초해상도(super resolution)가 적용된 영상을 획득하였다. 이에 대한 성능 평가는 최대 신호대잡음비(peak signal to noise ratio, PSNR), 구조적 유사도(structural similarity index measure, SSIM), 감마나이프 방사선수술(gamma knife radiosurgery, GKRS)의 좌표계로 평가하였다. 그 결과, 원본영상을 기반으로 영상 품질이 개선된 영상의 PSNR과 SSIM은 높은 수치를 나타냄으로써 MRI 영상의 재구성이 문제없이 이루어졌고, GKRS의 수술 좌표계 또한 변화를 보이지 않았다. 결론적으로 딥러닝 영상 재구성 기법은 영상 품질 향상과 영상 보존에서 뛰어난 성능을 보임과 동시에 좌표계도 변화를 보이지 않아서, 딥러닝 영상 재구성 기법은 감마나이프 수술 계획에 유용하게 사용할 수 있는 기법임을 확인하였다.

국내 수박(Citrullus lanatus) 품종의 발아율에 대한 Solid Matrix Priming(SMP)의 영향을 평가하였다. Micro cel-E가 SMP 처리에 가장 이상적인 matrix로 밝혀졌으며, 종자:matix:물의 비율은 10:5:10(w/w/w)로, 25°C 에서 3일 동안 처리했을 때 유근의 돌출없이 발아속도가 촉진되었다. SMP 처리 과정 동안 초기 4시간 동안의 수분 흡수율은 급격하게 증가했으며, 이후 72시간 동안은 더 느린 속도로 흡수되었고, 처리 마지막 시간까지 수분 흡수 율은 41%이었다. 발아 온도와 상관없이, SMP 처리된 종자는 발아 시간이 단축되면서 발아율이 향상되었다. 특히, 최적 발아 온도보다 낮은 온도에서 발아율이 높았다. 품종별 차이는 있었으나, 특히 ‘해찬꿀’과 ‘리코스위트’ 품종 에서 발아율이 유의미하게 증가하였다. 또한 일부 품종에서 SMP 처리 종자의 유묘출현율과 초장, 생체중이 무처 리에 비하여 증가한 값을 보였으며, SMP 처리로 종자의 발아속도 및 유묘활력을 증진시켜 우량 묘 확보가 가능한 것으로 판단되었다.

The demand for secondary batteries is increasing rapidly with the popularization of electric vehicles and the expansion of wireless electronic devices. However, the most widely used lithium-ion batteries are subject to frequent fire incidents, limiting market growth. To avoid flammability, solid electrolyte-based systems are gaining attention for next-generation lithium-ion batteries. However, challenges such as limitations in ionic conductivity and high manufacturing costs require further research and development. In this study, we aim to identify a new nitrogen-based solid electrolyte material that has not yet been widely explored. We propose a methodology for selecting the final material through high-throughput screening (HTS), detailing the methods used for material selection and performance evaluation. In addition, we present ab initio molecular dynamics (AIMD) calculations and results for nitrogen-substituted materials with carbon and oxygen replacements, including Arrhenius plots, activation energy, and the predicted conductivity at 300K for the material with the highest Li-ion conductivity. While the performance does not yet surpass the ionic conductivity and activity of conventional solid-state electrolytes, our results provide a systematic framework for exploring and screening new solid electrolyte materials. This methodology can also be applied to the exploration of different battery materials and is expected to contribute significantly to the innovation of next-generation energy storage technologies.

The purpose of this study is to examine the psychological impact of stroke, particularly post-stroke depression, anxiety, and cognitive impairment, while emphasizing the need for early intervention and personalized care to improve long-term outcomes for survivors. It explores the prevalence of these conditions, which are often underrecognized, and the varying effectiveness of intervention strategies such as pharmacological treatments, psychotherapy, and multidisciplinary rehabilitation. The findings reveal that neurological damage significantly affects mental health, complicating recovery, but highlight that early, individualized care plans tailored to patient needs can improve outcomes. The review underscores the importance of integrating mental health support into stroke rehabilitation to enhance recovery and calls for future research to address gaps in mental health care within these frameworks, advocating for a holistic, multidisciplinary approach to better support stroke survivors and their families.

This study aims to prepare reference data that can be used to improve the size suitability of elderly men’s casual wear. The sizes of men aged 65–84 from the 8th Size Korea were analyzed and compared with those aged 45–54. First, as a result of classifying their body types according to Syzing systems for male adult’s garments (KS K 0050), more than 50% of the drop body types were “a protruding belly type (BB),” and more than 95% of the lower body types were “a thick waist type (B).” Additionally, elderly men with type BB or B were 3–5cm shorter in height, waist height, chest circumference, and hip circumference than middle-aged men. As there are currently only a few brands for elderly men, this means that the following problems may arise: If an elderly man wears a middle-aged man’s top based on his chest size, the chest and hip circumferences are adequate, but the length is insufficient, the waist circumference is insufficient, and the shoulder width is considered to be excessive. Similarly, pants designed to fit a waist size designation for middle-aged individuals will be larger than intended in terms of length, hip circumference, and thigh circumference.

본 연구에서는 국내에서 판매되는 24개 건어포 및 조미 건어포 제품의 종 판별 및 표시사항 준수 여부를 평가했 다. 이러한 수산가공품에 사용된 원재료의 종판별을 위해 cytochrome c oxidase subunit I 및 cytochrome b 유전자 의 염기서열을 분석하여 NCBI GenBank 및 BOLD 데이 터베이스에 등록되어 있는 생물종의 염기서열과 비교 후 계통 분석을 수행했다. 분석 결과 13개 종(Hyporhamphus quoyi, Gadus chalcogrammus, Lophius litulon, Conger myriaster, Paramonacanthus pusillus, Hyporhamphus sajori, Gadus macrocephalus, Hoplobrotula armata, Callionymus meridionalis, Liparis tanakae, Dosidicus gigas, Lagocephalus cheesemanii, and Takifugu vermicularis)이 확인되었다. 일반 명(장어, 오징어 등)을 포함할 경우 16개 제품(66.7%)에서 표시사항과 판별된 종 간에 불일치가 확인되었으며, 일반 명을 제외할 경우 불일치 비율은 41.7%로 감소했다. 식품 유형별로는 조미건어포 제품(n=20, 70%)에서 건어포 제품 (n=4, 50%) 보다 높은 비율의 불일치 비율이 관찰되었다. 원산지별 분석 결과 특정 국가와 불일치 비율과의 상관성 은 확인할 수 없었다. 이러한 연구 결과는 건포류 제품의 주기적 모니터링 수행 및 수산물의 국명 표시 선을 위한 기초자료로 쓰일 수 있을 것이다.

Moringa oleifera, a versatile plant, has been traditionally used to treat various ailments and is gaining scientific attention due to its potential as a medicine. Native to the Indian subcontinent, it is widely grown in tropical and subtropical regions, thriving in Asia, Africa, and South America, especially in arid climates. This study explores the antioxidant potential of Moringa oleifera leaf extract (MOLE), employing a comprehensive screening approach with various solvents to identify the most effective extraction method. Initial experiments assessed antioxidant efficacy and yield using distilled water (D.W.), 95% ethanol, and 95% methanol. Among these, 95% ethanol extract demonstrated superior antioxidant activity, confirmed through assays such as 2,2-diphenyl-1-14 picrylhydrazyl (DPPH) radical scavenging assay, total polyphenol content analysis, and reducing power assay. In addition, with the 95% ethanol MOLE, a higher extraction efficiency was yielded compared to other solvents, making it the most effective for large-scale preparation. HPLC analysis revealed the presence of key bioactive compounds, including ellagic acid, rutin, Q-3-O, quercetin, and kaempferol. Results revealed that MOLE, prepared using 95% ethanol, exhibited remarkable antioxidant properties, attributed to its rich polyphenolic content. This research underscores the therapeutic potential of MOLE as a natural antioxidant source and highlights the importance of solvent optimization in phytochemical extractions.

In this study, an simultaneous LC-MS/MS multi-residue analytical method was developed and validated for the residues of six neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, imidacloprid, thiacloprid, and thiamethoxam) in honey. Sample preparation included a combination of QuEChERS extraction kit and liquid-liquid extraction method to effectively extract pesticide components from the honey matrix and optimized analytical conditions to achieve high sensitivity and selectivity. The limits of detection (LOD) and the limits of quantitation (LOQ) were set in the range of 6-15 ng/mL and 19-44 ng/mL, respectively and the correlation coefficient (R²) was greater than 0.99, confirming good linearity. In addition, the intra-day recoveries for each pesticide were 75-104%, and the coefficient of variation (CV) was less than 20%, which met the guideline recommended by the Ministry of Food and Drug Safety. The LC-MS/MS method developed in this study is expected to be used as a multi-residue analysis method for 6 neonicotinoid pesticides in honey.

Clove (Syzygium aromaticum) is a highly valued medicinal plant native to Aisa. Widely used as a spice, renowned for its medicinal properties, particularly in Ayurveda and traditional Chinese medicine. In this study, clove bud extract (CBE) was prepared at different ethanol concentrations of 50%, 80%, and 90%, respectively. The antioxidant activity of the CBE was evaluated through DPPH, polyphenol, and reducing power assays, revealing its strong antioxidant potential, with 90% ethanol being the most effective extract. HPLC analysis identified eugenol (8.7 mg/g) as the major active compound, known to possess anti-inflammatory and antioxidant properties. Given the role of oxidative stress and inflammation in atopic dermatitis (AD), the therapeutic potential of CBE was explored using a 1-chloro-2, 4-dinitrobenzene (DNCB)-induced AD mouse model. Five-week-old BALB/c mice were induced with AD by topical application of DNCB. CBE was administered topically to the affected skin (back and ear) areas for 4 weeks. The treatment of CBE significantly reduced the severity of clinical dermatitis, decreased epidermal thickness, and lowered mast cell and eosinophil infiltration in skin tissue, as observed through hematoxylin eosin staining and toluidine blue staining. The results demonstrated CBE as a promising therapeutic agent for managing AD through its regulation of skin inflammation and oxidative stress, making it a potential candidate for future treatments of inflammatory skin disorders.

Background: Cisplatin, a chemotherapeutic agent often causes nephrotoxic side effects. Lipopolysaccharide (LPS) is known to induce pro-inflammatory responses, often leading to septic renal injury. We hypothesized that the combination of cisplatin and LPS would amplify renal injury, thereby improving a renal injury model. Therefore, we administered both agents to mice and evaluated renal injury indicators. Methods: Eight-week-old male C57BL/6 mice were injected with cisplatin (8, 10, or 12 mg/kg) and LPS (5 mg/kg) on days 1 and 4 following of each week. Mice were euthanized at specific time points to assess renal injury. Body weight, renal weight, area, and BUN levels were measured to evaluate renal damage. Additionally, hematoxylin and eosin (H&E) and Masson’s trichrome (MT) staining were performed to assess histological changes. Results: The combination of cisplatin and LPS significantly reduced body and renal weight compared to cisplatin alone. A high dose of cisplatin (12 mg/kg) resulted in a 50% mortality, while, lower doses (8 and 10 mg/kg) showed 100% survival. Significant renal injury was observed in the 10 mg/kg cisplatin group administered for two weeks. In the 8 mg/kg cisplatin group, no changes were observed after two weeks, but renal damage appeared after four weeks. Histological evaluations in the 10 mg/kg cisplatin group administered for two weeks showed renal injury features, including tubular damage and fibrosis. Conclusions: Administering cisplatin (10 mg/kg) with LPS for two weeks or cisplatin (8 mg/kg) with LPS for four weeks resulted in a distinct renal injury, effectively establishing a renal injury mouse model.

Following the previous study, which investigated the pharmacological properties of the Technekitty injection (Tc-99m), the toxicity of a single intravenous administration of the Technekitty injection (Tc-99m) and the side effects that may occur at the diagnostic dose were confirmed. The Technekitty injection (Tc-99m) was administered intravenously once at a dose of 0, 0.67, 2.0, and 6.0 mCi/kg to 5 male and female rats per group. Mortality, general symptom observation, and weight measurement were performed for 2 weeks, followed by observation of autopsy findings. There were no deaths, and no statistically significant weight change was observed. No abnormal systemic signs related to the Technekitty injection (Tc-99m) were observed. These results confirmed that Technekitty injection (Tc-99m) can be safely administered intravenously at doses up to 6.0 mCi/kg. Additionally, technetium-99m at an average dose of 2 mCi (74 MBq) has been verified as a diagnostic dose without adverse effects, allowing the Technekitty injection (Tc-99m) to be used safely without side effects at this dosage. This study demonstrates that the Technekitty injection (Tc-99m) has a wide safety margin, supporting its potential for clinical application. Moreover, these findings align with the nonclinical safety standards for radiopharmaceuticals, reinforcing its utility in veterinary medicine. The Technekitty injection (Tc-99m) is expected to be applicable for clinical diagnosis as a veterinary drug in Korea.