The blockage rate for three kinds of nets commonly used in agricultural facilities was assessed by using the image acquisition and its relevant processing. By using both empirical relations presented by Idel’chik and Richards and Robinson, and the blockage rate obtained from the image processing, the pressure drop through the nets was predicted and also compared with wind tunnel experiment results. The results of the study showed that the blockage rate of the net was discriminated according to such factors as the magnitude of nets, the existence of inside threads, the thickness and number of threads. In addition, the blockage rate for the incident angle of 0° when the wind blew at the front had the range of 0.22－0.29 (0.22－0.32 when considering whole incident angles from 0° to 45° by 15°). For the nets with the blockage rate of about 30% or below, the prediction by the empirical relations of by Idel’chik and Richards and Robinson showed a little higher pressure drop overall than that of the wind tunnel test, but the use of the empirical relations and the blockage rate could be thought of as providing effectively meaningful guidelines for the safe design of agricultural facilities including nets because the wind tunnel test has been tedious and expensive. Further research and potential application on the prediction technique of the pressure drop, regarding both a subtle deformation by the wind and manufacturing methods with regard to the level of knots and the existence of inside threads, needs to be done for the nets with higher blockage rate.

The change in pressure measurement according to the low pressure tap blockage rate of the Venturi flowmeter used in domestic nuclear power plants was approached numerically. Blockage rates were modeled dividing by 1/10dT to the downstream side of the low pressure tab to identify differential pressure changes. As a result, differential pressure increased in proportion to the blockage rate, and there was no change in differential pressure measurement at 10 to 40 percent with relatively small blockage rate, but the error rate of 50% to 0.3% or higher was shown.

본 논문에서는 풍동에서 수행되는 날개 길이가 0.8m와 1.5m인 두 수직축형 풍력발전기 및 날개 길이가 0.74m인 수평축형 풍력발전기의 성능평가시험으로부터 출력량을 얻기 위하여 수직축형 풍력발전기 및 수평축형 풍력발전기의 폐쇄효과를 고려하였다. 풍속이 증가함에 따라 서로 다른 날개 길이를 갖는 두 수직축형 풍력발전기 및 수평축형 풍력발전기의 출력량을 측정하였고 폐쇄효과에 기인한 폐쇄계수를 사용하여 출력량을 보정하였다. 날개 길이가 0.8m인 수직축형 풍력발전기에 대해 RPM과 폐쇄계수 사이의 관계는 풍속이 5m/s, 8m/s 및 10m/s일 때 거의 동일하였다. 날개 길이가 0.8m인 수직축형 풍력발전기에 대한 폐쇄계수는 RPM이 증가함에 따라 0.91에서 0.88의 범위에 있었고, 날개 길이가 1.5m인 수직축형 풍력발전기에 대한 폐쇄계수는 RPM이 증가함에 따라 0.85에서 0.82의 범위에 있었다. 또한 날개 길이가 0.74m인 수평축형 풍력발전기에 대한 폐쇄계수는 RPM이 증가함에 따라 0.84에서 0.77의 범위에 있었다. 본 연구를 통해 풍동에서 수직축형 풍력발전기의 회전자 면적이 클수록 폐쇄계수는 작아진다는 것을 확인할 수 있었다.

본 연구에서는 시험부 벽면압력을 이용한 폐쇄효과 보정 방법에 대한 연구를 수행하였다. 이를 위해 폐쇄형 시험부내의 원형실린더 주위 유동장에 대한 수치적 해석을 수행하여 폐쇄효과 변화에 따른 유동장 및 벽면압력 변화를 연구하였다. 본 연구에서 제시한 벽면압력측정 방법은 Maskell 방법과 Hackett과 Cooper 방법으로 보정된 결과 및 자유흐름 상태와 비교하여 그 타당성을 검증하였다. 그 결과 폐쇄형 시험부 내의 원형실린더의 경우 Maskell 방법과 Hackett과 Cooper 방법은 과보정의 경향을 보였으며, 본 연구에서 제시한 보정 방법은 자유흐름 결과와 일치되는 우수한 보정결과를 보임을 확인하였다.

Molecular targeting for the altered signaling pathways has been proven to be effective for the treatment of many types of human cancer, including colorectal cancer (CRC). The dual phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor BEZ235 has shown to exhibit potent antitumor activity against solid tumors. Autophagy is a cellular lysosomal catabolic process to maintain metabolic homeostasis, which has been known to be induced in response to many therapeutic agents in cancer cells. This process is negatively regulated by mTOR and often acts as prosurvival or prodeath mechanism following cancer therapeutics. The current study was designed to investigate the antiproliferation activity of BEZ235 and to evaluate the role of autophagy induced by BEZ235 using HCT15 CRC cells bearing ras oncogene mutation. We found that BEZ235 decreases cell viability, which was mostly dependent on G1 arrest of cell cycle via suppression of cyclin A expression. BEZ235 affects PI3K/Akt/mTOR signaling pathway by increasing the phosphorylation of AKT at Ser473 and RAS/RAF/MEK/ERK pathway by decreasing the phosphorylation of ERK at Tyr204. BEZ235 also stimulated autophagy induction as evidenced by the increased expression of LC3-II and abundant acidic vesicular organelles (AVOs) in the cytoplasm. In addition, the combination of BEZ235 with autophagy inhibitor chloroquine, a known antagonist of autophagy, counteracted the antiproliferation effect of BEZ235. Thus, our study indicates that autophagy induced in response to BEZ235 treatment appears to act as cell death mechanism in HCT15 CRC cells.

위성항법시스템의 기술발전이 지속적으로 진행되고 있지만 여전히 신호차폐가 빈번히 발생하는 지역에서는 측위정확도 확보에 어려움을 겪고 있다. 이 연구에서는 통합 GPS/GLONASS 이중차분 상대측위 알고리즘을 구현하고 신호차폐 환경의 시뮬레이션을 수행해 그 성능을 검증하였다. 동쪽, 서쪽, 남쪽 방향으로 고층건물에 의해 신호차폐가 발생하는 환경을 시뮬레이션 하고 시뮬레이션 상황에 따른 GPS와 GPS/GLONASS의 정확도 평가를 수행하였다. 그 결과, 신호차폐 시뮬레이션 환경에서는 GPS/GLONASS가 GPS에 비해 최소 0.3m에서 최대 13m이상의 수평정확도가 향상되었다.