간행물
Journal of Biomedical Research
- 발행기관 충북대학교 동물의학연구소
- 자료유형 학술지
- 간기 계간
- ISSN 1976-7447 (Print)2287-7363 (Online)
- 수록기간 2000 ~ 2015
- 주제분류 의약학 > 수의학 의약학 분류의 다른 간행물
- 십진분류KDC 528DDC 636
권호리스트/논문검색
Vol. 11 No. 4 (2010년 12월) 6건
1.
2010.12
구독 인증기관 무료, 개인회원 유료
Influenza virus infection is a zoonosis that results in high mortality in animals and humans. Several recent avian influenza outbreaks have posed a significant public health threat to humans because there have been many cases of direct interspecies transmission from birds to humans. Influenza virus infection causes acute respiratory failure, which is the main cause of death, while chronic influenza virus infection in the central nervous system results in neural dysfunction. Of particular interest, according to one report, a group of patients who recovered from influenza virus infection during pandemics showed neuropsychiatric disorders, including depression, schizophrenia, and Parkinsonism. Thus, study of the etiology of neuropsychiatric disorders caused by influenza virus infection is needed. In order to conduct necessary experiments, it is essential to reproduce neurological phenomena that are manifested by human patients who have recovered from influenza virus infection using laboratory animals. In this review, we will discuss some of the facts that should be considered when establishing an animal model for study of central nervous system responses to influenza virus infection using mice.
4,000원
2.
2010.12
구독 인증기관 무료, 개인회원 유료
The aim of this study was to evaluate the alleviative effects of a nude pack containing black tea water extract (NPBT) on inflammation and skin barrier damage in hairless mice. Skin inflammation and skin barrier damage were induced by UVB irradiation to the backs of hairless mice for five weeks. And, at the same time, saline (C), NPBT (1%: E1, 2%: E2), and 0.01% retinoic acid diluted with polyethylene glycol (PC) were applied topically twice per day, five days per week, for a period of five weeks. The skin erythema indices of the E1 and E2 groups were significantly lower (p<0.05) than those of the C group through one week after the beginning of the experiment. Meanwhile, water contents of the E1 and E2 groups were significantly higher (p<0.05) than those of the C group through two weeks after the beginning of the experiment. Remarkable thickening of epidermis and dermis was observed in the C group, compared with the PC, E1, or E2 groups. In the C group, infiltration of many inflammatory cells, including neutrophils and lymphocytes, was observed in dermis and a large number of mast cells were observed in dermis and hypodermis, and the degree of degranulation was remarkable. However, these phenomena were alleviated in the PC, E1, and E2 groups. Therefore, NPBT could have considerable inhibitory efficacy on inflammation and skin barrier damage induced by UVB irradiation.
4,000원
3.
2010.12
구독 인증기관 무료, 개인회원 유료
Yun-Bae Kim, Tae Myoung Kim, Jae Myun Ryu, Im Kwon Seo, Dongsun Park, Sun Hee Lee, Dae-Kwon Bae, Goeun Yang, Yun-Hui Yang, Tae Kyun Kim, Ehn-Kyoung Choi, Seock-Yeon Hwang
The effects of isotonic saline on corneal penetration, thickness, and injury, as well as lacrimal secretion in a rat model of dry eye were investigated, in comparison with distilled water. Male Sprague-Dawley rats received intraperitoneal administration of atropine sulfate (20 mg/kg) and their eyes were exposed to dry (relative humidity 25-35%) air flow (2.4 m/sec), under Zoletil anesthesia, for 5 hr to induce dry eye. During the period of dry eye induction, distilled water or isotonic saline (5 μl) was instillated onto the cornea every 30 min. Corneal penetration was measured through fluorescein dye quantification, and corneal thickness and injury were examined under a microscope. Lacrimal (tear) secretion and mucin-like glyocoprotein excretion from goblet cells were measured using the Schirmer test and microscopy, respectively. In dry eye rats treated with distilled water, corneal thickness, tear secretion, and mucin-like glycoprotein excretion were decreased to 74.0%, 74.1%, and 46.3% of normal levels, respectively, resulting in marked corneal injury and a significant increase in corneal penetration. In comparison, treatment with isotonic saline resulted in recovery of lacrimal secretion, in spite of a slight improvement of mucin-like glycoprotein excretion, and thereby prevented corneal penetration of fluorescein by 10%. The results indicate that repeated instillation of isotonic saline could provide slightly greater protection from corneal injury, compared with distilled water by facilitating lacrimal secretion, in addition to relief of inconvenience and pain.
4,000원
4.
2010.12
구독 인증기관 무료, 개인회원 유료
For application of nano-sized material in various fields, toxicity evaluation of nano-sized material is important. In the current study, a suspension of 50 nm-sized zinc oxide (ZnO) nanoparticles at a dose of 1 g/kg body weight was injected intraperitonially into mice in order to identify the toxicity of ZnO nanoparticles. After 24 h, the blood and liver were taken and analyzed. According to the results of hematological analysis, white blood cell (p<0.001), mean corpuscular hemoglobin (p<0.001), and mean corpuscular hemoglobin concentration (p<0.05) in the ZnO nanoparticle treated group showed a significant decrease, compared to the control group. In serum biochemistry analysis, alanine aminotransferase (p<0.001) and aspartate amino-transferase (p<0.05) also induced a significant increase in the ZnO nanoparticle treated group, compared with the control group. In the histopathological examination, liver in mice treated with ZnO nanoparticles showed edema and degeneration in hepatocytes. Therefore, it is concluded that the liver is the target organ for 50 nm ZnO intraperitoneal exposure. In the future, greater attention should be paid to the potential toxicity induced by various routes and doses of ZnO nanoparticles.
4,000원
5.
2010.12
구독 인증기관 무료, 개인회원 유료
Sang-Yoon Nam, Ki Youn Jung, Jung-Min Yon, Kyong-Ok No, In-Jeoung Baek, Chunmei Lin, A Young Jung, Jong Geol Lee, Beom Jun Lee, Young Won Yun
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a unique antioxidant enzyme involved in reduction of peroxidized phospholipids within biomembranes. To investigate the expression pattern of the PHGPx gene during fetal development, in situ hybridization analyses were performed using mouse FITC-labeled PHGPx cRNA probes in fetal tissues on embryonic days (Ed) 13.5-18.5. During these periods, PHGPx mRNA appeared in the developing telencephalon, diencephalon, spinal cord, and spinal ganglion. In particular, PHGPx mRNA was strongly expressed in pyramidal cells of the cerebral cortex. On Eds 17.5-18.5, PHGPx mRNA was detected in various tissues including liver, intestinal villi and crypt, pancreas, lung, and olfactory epithelium of the nasal cavity. In addition, PHGPx mRNA was highly expressed in the inner ear on Eds 14.5-18.5, brown fat on Ed 17.5, and adrenal gland on Ed 18.5. It is conceivable that PHGPx may act as an important antioxidant against fetal oxidative stress during mouse organogenesis.
4,000원
6.
2010.12
구독 인증기관 무료, 개인회원 유료
A nine-month-old male Pekingese weighing 5.7 kg was admitted to the Veterinary Medical Center at Chungbuk National University with a history of acute nonambulatory tetraparesis after minor trauma. A diagnosis of atlantoaxial instability with a dens axis fracture was based on examination of survey spinal radiographs and was confirmed during surgery. A modified ventral fixation technique using cortical screws was used for stabilization of the atlantoaxial joint. Serial evaluation based on radiographic and neurologic assessment was performed eight weeks after surgery. Symptoms of tetraparesis disappeared gradually, and arthrodesis of the atlantoaxial joint using a ventral fixation technique has maintained stable fixation.
4,000원
