간행물
Journal of Biomedical Research
- 발행기관 충북대학교 동물의학연구소
- 자료유형 학술지
- 간기 계간
- ISSN 1976-7447 (Print)2287-7363 (Online)
- 수록기간 2000 ~ 2015
- 주제분류 의약학 > 수의학 의약학 분류의 다른 간행물
- 십진분류KDC 528DDC 636
권호리스트/논문검색
Vol. 10 No. 1 (2009년 3월) 6건
1.
2009.03
구독 인증기관 무료, 개인회원 유료
Four-week repeated-dose toxicity of Misaengtang (MST) was evaluated according to Toxicity Test Guideline of Korea Food and Drug Administration using 6-week-old Sprague-Dawley rats. Based on the results of preliminary single-dose toxicity study, confirming safety up to an upper-limit dose, MST was dissolved in drinking water and orally administered at doses of 500, 1,000, or 2,000 mg/kg for 28 days. All doses including the upper-limit limited dose (2,000 mg/kg) of MST did not cause any abnormalities of rats, including mortality, clinical signs, body weight gain, feed/water consumption, necropsy findings, organ weights, hematology and blood biochemistry. Rather, high doses (1,000-2,000 mg/kg) of MST reduced the serum levels of alanine transaminase, aspartate transaminase, creatinine phosphokinase, lactate dehydrogenase and triglycerides, in addition to an increase in glucose, indicative of protective effects on hepatic and muscular injuries. Both maximum-tolerable dose and no-observed-adverse-effect level were not determined. The results indicate that long-term intake of high-dose MST might not induce general adverse-effects.
4,000원
2.
2009.03
구독 인증기관 무료, 개인회원 유료
Dyed loess and charcoal fabrics are sold in market as bedding. They have a lot of functions so that people are getting to increase their expenditure for them. Thus we investigated a repellent effect of loess fabrics and charcoal fabrics against house dust mites. The evaluation of the repellent effect of dyed loess fabrics and charcoal fabrics was conducted by using Dermatophagoides farinae and D. pteronyssinus. We compared the repellent effect of dyed loess fabrics at different doses of 0.3, 1.0, 3.2, 10.0 ㎎/㎠ and dyed charcoal fabrics at different doses of 0.3, 0.6, 1.0 ㎎/㎠. Commercial loess fabrics did not have a repellent effect against house dust mites. but commercial charcoal fabrics had the repellent effect by 78% against them. In case of dyed charcoal fabrics added with charcoal powder over 0.6 ㎎/㎠, they showed the repellent effect by over 80%. These results suggest that loess fabrics and charcoal fabrics have a repellent effect of against house dust mites and they can be commercially used for the purpose.
4,000원
3.
2009.03
구독 인증기관 무료, 개인회원 유료
Immunohistochemical localization of vimentin, glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), neuron-specific enolase (NSE) were performed to confirm the canine schwannoma diagnosed histologically. Biopsy samples from skin masses occurred on a 6 year old female dog and a 13 year old female dog were used for immunohistochemical analysis. Histologically, the tumor tissues showed the characteristics of schwannoma mainly composed of predominantly fusiform or spindle cells. The cells are arranged in small interwoven bundles with intervening fibrous and mucinous stroma that imitate a herringbone pattern. The cell nuclei have an elongated, wavy, buckled appearnce and closely bunched together. In high magnification, mitotic figure, nuclear hyperchromatism, pleomorphism and poorly defined cytoplasms were noted. the vimentin was highly expressed in the cytoplasm of all neoplastic cells. Positive reactions against NSE and GFAP, widely used to suggest a neural origin of cell types, are observed in cytoplasms of tumor cells. These results can be used as a reference data for definitive diagnosis of canine schwannoma.
4,000원
4.
2009.03
구독 인증기관 무료, 개인회원 유료
Various acaricidal agents have been used to reduce the dust mite population. On the point of keeping people away from mite allergens, however, repelling mites from the living space of human is more effective than just killing them, because the dead bodies of mites still act as allergen. To examine the potential of Artemisia in controling house dust mites, Artemisia extract was evaluated for its repellency to Dermatophagoides farinae and D. pteronyssinus. Repellency tests were performed using filter-paper circles cut in halves. The Artemisia extract was applied on each half at concentrations of 0, 0.1, 0.2, 0.4 and 0.8㎕/㎠. Proper repellent effects of Artemisia extract on house dust mites were observed at the concentrations of ＞0.4㎕/㎠. As a positive control, lavender essential oil was used at concentrations of 0, 0.0125, 0.025, 0.05 and 0.1㎕/㎠. Lavender oil showed proper repellent effects at concentrations of ＞0.05㎕/㎠. These results suggest that Artemisia extract has potential to control the house dust mites, and might be useful as a dust mite repellent.
4,000원
5.
2009.03
구독 인증기관 무료, 개인회원 유료
Beom Jun Lee, Jin-Joo Hue, Mi-ha Im, Bong Su Kang, Jun-hyeong Kim, Sang Yoon Nam, Young Won Yun, Jong Soo Kim
This study was carried out to investigate effect of herbal extracts mixtures on hair growth in an alopecia model of C57BL/6 mice. There were 4 experimental groups including distilled water (DW, negative control), 25% ethanol(EtOH, vehicle control) and two herbal extract mixtures (HE-1 and HE-2). HE-1 included Polygonum and Brassica campestris extracts and HE-2 included Mulberry root and Gardenia extracts. The 6 weeks-old C57BL/6 male mice were shaved with an electric clipper and the test compounds were topically treated with 0.2 ml per mouse daily for 3 weeks. The hair re-growth was photographically determined at days 0, 4, 7, 10, 14, 17, and 21. The number of mast cells which is an important modulator of hair growth was counted in 1 cm of dorsal skin section of mice. There were no clinical signs in all experimental groups. As the results of photometric analysis, the topical application of the herbal extracts (HE-1 & 2) for 2 weeks to dorsal skin accelerated hair re-growth remarkably faster than that of DW group (p＜0.05). Activity of alkaline phosphatase (ALP) was significantly increased in EtOH group compared to DW group (p＜0.05). Both herbal extract mixtures also increased the ALP activity, but it was not significantly different from DW. Treatment of mice with HE-2 significantly increased mast cell population compared to EtOH. Taken together, these results suggest that herbal extract mixtures used in this study may have hair-growth promoting activities and can be useful for treatment for male pattern baldness or alopecia in humans.
4,000원
6.
2009.03
구독 인증기관 무료, 개인회원 유료
A 14-year-old intact female, mixed dog was presented with hematuria and strangury. Mass in the abdominal cavity was seen on radiographs and ultrasound. On the cytological examination in the urethra, clusters of pleomorphic epithelial cell were found. Tissues of the urethra and the urinary bladder were obtained at the time laparotomy and determined the extent of the mass. Transitional cell carcinoma (TCC) of the urinary bladder was found in histopathologic characteristics. Urinary diversion after removal of a complete full section of the TCC in bladder wall was performed. Piroxicam, as a medical therapy for TCC, was orally administrated. Surgical operation and chemotherapy were selected with the goal of maintaining and improving quality of life.
4,000원
