간행물
Journal of Biomedical Research
- 발행기관 충북대학교 동물의학연구소
- 자료유형 학술지
- 간기 계간
- ISSN 1976-7447 (Print)2287-7363 (Online)
- 수록기간 2000 ~ 2015
- 주제분류 의약학 > 수의학 의약학 분류의 다른 간행물
- 십진분류KDC 528DDC 636
권호리스트/논문검색
Vol. 10 No. 2 (2009년 6월) 6건
1.
2009.06
구독 인증기관 무료, 개인회원 유료
Flavonoids are a large family of polyphenolic compounds synthesized by plants that have a common chemical structure. Flavonoids may be further divided into subclasses, Anthocyanidins, Flavan-3- ols, Flavanones, Flavonols, Flavones, Isoflavones. Flavonoids have antioxidant and antiradical activities. The antiradical efficacy of flavonoids have established structure-activity relationships (SAR) of the antioxidant activity. Reactivity of flavonoids is highly dependent on the configuration of OH groups on the flavonoid B and C rings, there being little contribution from A ring to antioxidant effectiveness. This short article presents the current knowledge on structural aspects on their free radical reactions of flavonoids.
4,000원
2.
2009.06
구독 인증기관 무료, 개인회원 유료
The Notch signaling pathway regulates cell proliferation, apoptosis and cell fate decision. Recent preclinical and clinical evidence supports a pro-oncogenic function for Notch signaling in several solid tumors including breast and prostate cancer. Consequently, there is increasing interest in targeting Notch signaling therapeutically in cancer patients. Notch inhibitors, particularly gamma-secretase inhibitors, are being investigated as candidate cancer therapeutic agents. However, rational targeting of Notch signaling in cancer will require a systematic exploration of several areas that remain incompletely understood. Therefore, a clear understanding of the Notch signaling and its cross-talk with other signaling cascade will increase our ability to design rational combination regimens for cancer therapy.
4,000원
3.
2009.06
구독 인증기관 무료, 개인회원 유료
The Maillard Reaction Products (MRPs) such as Glucose-tyrosine (Glu-Tyr) and Xylose-arginine (Xyl-Arg) have antioxidant, antimutagenic, and antibacterial effects. However, to date, still little is known about the other biological effects of the MRPs. In this study, we investigated whether the fructose-tyrosine MRP, 2,4-bis(p-hydroxyphenyl)-2-butenal (Fru-Tyr), could modulate cell cycle progression and NF-κB activity, and thereby induce apoptotic cell death of colon cancer cells. Treatment with different concentrations (10-40 μg/ ml) of Fru-Tyr for 24 h inhibited colon cancer cell (SW620 and HCT116) growth followed by induction of G2/M phase cell cycle arrest and apoptosis in a dose-dependent manner. We also found that Fru-Tyr suppressed tumor necrosis factor-alpha (TNF-α)-induced NF-κB transcriptional activity. Moreover, Fru-Tyr induced the expression of apoptotic gene, cleaved caspse-3. These results suggest that Fru-Tyr inhibited colon cancer cell growth through induction of G2/M phase cell cycle arrest and apoptotic cell death by modulating of NF-κB.
4,000원
4.
2009.06
구독 인증기관 무료, 개인회원 유료
A level of dietary iron may play a role in colon carcinogenesis. The effect of dietary iron on colon carcinogenesis was investigated in male ICR mice. Five-week old mice were acclimated for one week and fed on iron-normal diet (35 ppm Fe), iron-deficient diet (3 ppm), or iron-overloaded diet (350 ppm Fe) for 8 weeks. Animals received three (0-2nd weeks after starting experiment) injections of azoxymethane (AOM; 10 mg/kg b.w.) to induce colonic aberrant crypt foci (ACF). There were five experimental groups including normal control without AOM, AOM+iron-normal diet (AOM+NFe), AOM+iron-deficient (AOM+LFe), AOM+ironoverloaded diet (AOM+HFe) groups. The total numbers of ACF and aberrant crypt (AC) were measured in the colonic mucosa after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. The hepatic iron levels were significantly dependent on the presence of iron in the diets. Iron-deficient diet significantly decreased the several hematological values. The values of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) were also significantly decreased in iron-overloaded or iron-deficient diet groups, compared with normal iron diet group. Dietary iron-deficiency decreased the numbers of ACF (64.9) and AC (79.8) per colon by 20.6 and 21.8%, respectively, compared with AOM+NFe group (72.4 ACF/colon and 90.3 AC/colon). However, ironoverloaded diet increased ACF (82.9) and AC (96.0) induction by AOM, compared with normal iron diet. These results suggest that dietary iron can affect the colon carcinogenesis in the animal model of mice.
4,000원
5.
2009.06
구독 인증기관 무료, 개인회원 유료
Jung-Min Yon, Doo Soo Kim, Ji-Hyun Lee, Yong-Jae Ryu, In-Jeoung Baek, Beom Jun Lee, Young Won Yun, Sang-Yoon Nam
Maternal hypoxia induced by a variety of exogenous oxidative stresses such as ethanol intake, diabetes, and cigarette during pregnancy provokes the impaired embryonic gene expression and developmental malformations. We investigated the gene expression patterns of the representative selenium containing antioxidant enzymes (selenoproteins) such as cytosolic GPx (cGPx), gestrointestinal GPx (GI-GPx), plasma GPx (pGPx), phospholipid hydroperoxide GPx (PHGPx), and selenoprotein P (SePP) in the cultured mouse embryos under normal or hypoxic (low oxygen state, 5% O2) condition at embryonic day 8.5 for 2 days using real-time PCR analysis. cGPx, pGPx, and SePP mRNAs were significantly decreased, but GI-GPx and PHGPx mRNAs were remarkably increased in the hypoxic state compared to normal gassing state (p<0.05). These findings indicate that hypoxic condition leads to the unusual expressions of selenoproteins during mouse organogenesis.
4,000원
6.
2009.06
구독 인증기관 무료, 개인회원 유료
Yun-Bae Kim, Dongsun Park, Jiyoung Oh, Tae Kyun Kim, Young Jin Cho, Sun Hee Lee, Dae-Kwon Bae, Yun-Hui Yang, Goeun Yang, Seock-Yeon Hwang
The present study was carried out to establish an animal model, displaying long-term learning and memory dysfunction, since single intracerebroventricular (icv) injection of amyloid β peptide (Aβ) causes a short-term memory impairment. Male ICR mice were fed a high-cholesterol diet (HCD) containing 3% cholesterol, 1% corn oil and 0.5% cholic acid, and 1 week later, icv injected with Aβ1-42 (5 μg/head). Learning/ memory function was assessed via passive avoidance performances 1 day and 2, 4, and 6 weeks after Aβ1-42 injection, in addition to blood biochemical analyses for lipid profiles and hepatic function. Total cholesterol, lowdensity lipoproteins and hepatic dysfunction parameters markedly increased, while high-density lipoproteins were reduced following HCD feeding. Whereas single injection of Aβ induced temporary memory loss 1 day after administration, exhibiting full recovery after 2 weeks, Aβ treatment in combination with HCD feeding lasted the learning/memory impairment up to 6 weeks. Therefore, it is suggested that hypercholesterolemia augments Aβ-induced memory loss, and that Aβ injection plus HCD feeding could be a long-term memorydeficit model suitable for long-term treatment with drugs or stem cells.
4,000원
