Primary breast sarcomas are very uncommon. They represent less than 1% of all primary breast malignancies and less than 5 % of all sarcomas. We report a case of a patient with primary breast sarcoma who underwent left breast conserving surgery with sentinel lymph node biopsy.

Background : Insect pests damages are increasing on the field of Lycium chinense under eco-friendly organic management and especially, pest damage of Gelechiidae (Ilseopsis parki Povolny) is serious. Currently, various eco-friendly organic materials are registered, but insecticidal activity against Gelechiidae was not verified. Therefore, this experiment was carried out to select eco-friendly organic materials showing insecticidal activity in Gelechiidae. Methods and Results : To test insecticidal activity, the Gelechiidae lavas were collected from the field and Nine eco-friendly organic materials were collected from the market. method. The insecticidal activity assay method was, putting Gelechiidae lavas on the 90mm petridish then water-diluted eco-friendly organic materials were sprayed onto the laver. Result of insecticidal activity was observed with a microscope 10 minutes, 2 hours and 18 hours after the treatment. Microscopic observation results, insecticidal activity was shown only in 5 out of 9 materials. Conclusion : As a result, Insecticidal activity against Gelechiidae was not effective in all tested materials, but the 5 eco-friendly organic materials showed the same effect in repeated experiments. In this study, we selected 5 materials out of 9 eco-friendly organic materials against Gelechiidae, then future studies are planned to select the most suitable materials by field testing the 5 eco-friendly organic materials.

Background : The most problematic disease in Boxthorn is Anthracnose. New variety with Anthracnose-resistant is good for high yield and Safe fruit production in open field. Therefore it is necessary to develop a New variety with Anthracnose -resistant and high yield. Methods and Results : The new boxthorn line, CB10511-104 was selected from the cross between Cheongun (IT232599) and CB08456-113 to breed new variety with high yield and Anthracnose-resistant in 2011. Its preliminary yield test was performed from 2012 to 2013 and the selected line was named Cheongyang 25. Its regional yield trials were carried out in Cheongyang, Yesan and Jindo for 3 years, from 2014 to 2016. Cheongyang 25 was registered as the new variety, Cheonggeum, in 2016. The specific characteristics were summarized as follows; Tree shape is open type and the leaf is round-lanceolate. The flowers are normal size and purple. The fruit is large size, round oval and yellowish red. The flowering was June 19 with medium flowering. Number of sprout branch by pruning was generated more than the check variety, Cheongmeong. The infection rates on leaves to Eriophys macrodonis Keifer was as strong as 39.6 percent. Anthracnose on fruits in open field was slightly similare compared to the check variety, but check variety was Anthracnose-resistant. The content of betaine and free sugar in dried-fruits were higher than that of the check variety. The dried-fruit yield was decreased about 17 percent in open field. Conclusion : This variety ‘Cheonggeum’ was suitable for cultivation in open field because of Anthracnose-resistant. It is necessary the companion variety, Cheonghong, because of self-incompatible.

Background : Black Non-Woven Fabric Mulch Culture was knowned increased crop Yield and saved weeding labor in Liriope Pilatyphylla Wang et Tang. But to the removal and planting labor is more needed, So some famers are avoidance that culting method. Methods and Results : So this study was experimented in order to selecting optimun removal time in Liriope Pilatyphylla Wang et Tang mulch culture. Removal time were conventional practices (in April next yesr), September, October and November. In early, Plant length, Root length, Leaf number and number of plants was the long and many by the sooner removal time and also, dry weight was heavier. Black non-woven fabric removal labor was saved by the sooner removal time. The main event of weeds were Cyperus serotinus Rottb and Portulaca oleracea L. In harvest time, Plant length and plants of numbers was the longest and heavier at conventional practice (in April next year) and November removed. Tuberous root number was the more in September removal, Because, the tuber was tall and long. Total1y consideration of the including weeds shooting, weeding labor and Growth and development situation, Black non-woven fabric removal optimum time was September or Conventional practices (in April next year). Conclusion : Black non-woven fabric optimum removal time was the september . In this experiment, increased yield 9, income 16 percent than conventional practices (in April next year).

Background : Natural Mortality Vinyl much culture are increased crop yield and saved weeding workforce. But research is insufficient that of Liriope Pilatyphylla Wang et Tang. Black non-woven fabric mulch culture are increased crop yield and superior to occurrence of weeds, but to the removal and planting more labor needed, so, Farmers are avoidance using that. Methods and Results : So this study designed in order to selecting the best covering material. Using in this study, covering materials were Conventional practices (non covering), Natural mortality vinyl and black non-woven fabric. Soil temperature was continued highly after planting from in mid-may to in august a regular. among them natural mortality vinyl mulch was the highest. Natural mortality vinyl mulch was the fastest that humidity of soil change and Growth and development situation by maintaining proper temperature and humidity. Non mulching was little change in temperature and humidity and the slowest in the Growth and development situation. The main event of weeds were Cyperus serotinus Rottb and Portulaca oleracea L. Weeding labor was saved from 43 to 57 percent in the natural mortality vinyl and black non-woven fabric mulch. Plant length was the shortest in the conventional practices and Root length, Leaf number and number of plants were little changed. Yield was increased from 27 to 29 percent in the natural mortality vinyl and black non-woven fabric mulch than conventional practices. Result of comprehensive economic analysis including weeding labor and yield, the natural mortality vinyl mulch culture was income increased 92 percent than conventional practices. Conclusion : Natural mortality vinyl mulch culture were weeds shooting controled and increased yield 39, income 92 percent than conventional practices (non covering).

Background : Acreage of rain-shelter plastic greenhouse to prevent anthrax is being gradually increased according to growing importance of safe Boxthorn production. But When Boxthorn is grown in the hot season in rain-shelter plastic greenhouse, Fertility decreases. The fertilization rate tends to be different according to cultivated variety and ventilation type of rain-shelter plastic greenhouse. Therefore it is necessary to identify cause and look for a solution. Methods and Results : In the experiment, ‘Cheongun’ cultivar was grown in the rain-shelter plastic greenhouses for the tests. Environment of rain-shelter plastic greenhouses, fertilization rate and density of flower visiting insect were investigated according to ventilation type. Pollen germination and pollen tube elongation on stigma were investigated according to temperature. In mid-July, the temperature on a clear day rose to 45℃ in rain-shelter plastic greenhouse of side vents. Pollen germination and pollen tube elongation on stigma were normal for 3 hours on 30, 35℃. Fertilization rate was somewhat reduced on 40℃ but Pollen germination and pollen tube elongation was good. On 45℃, fertilization rate was very poor and There was no pollen germination. Density of flower visiting insect in rain-shelter plastic greenhouse of roof and side vents was higher than that in rain-shelter plastic greenhouse of side vents. The fertilization rate on high temperature did not show any difference regardless of ventilation type. The rate of artificial cross-fertilization and airborne fertilization were high in rain-shelter plastic greenhouse of roof and side vents. It was necessary to improve airborne fertilization rate because airborne fertilization rate was significantly lower than artificial cross-fertilization regardless of ventilation type. Conclusion : When it was cultivated in rain-shelter plastic greenhouse, the reasons for the lowering of the fertilization rate were as follows. Density of flower visiting insect was low. Boxthorn, which was insect pollination crop, was needed sufficient flower visiting insect on flowering period. But it was insufficiency especially in rain-shelter plastic greenhouse of side vents. Another reason was decrease in pollen germination and pollen tube elongation. Pollen germination was suppressed in the high temperature.

Breast specific gamma imaging (BSGI) is a nuclear medicine breast imaging technique. The sensitivity of BSGI is unaffected by post-operative scars or implants, and thus, BSGI is helpful for the differential diagnosis of postoperative recurrence. Here, the authors report a case of diffuse chest wall recurrence on the side of radical mastectomy that was not detected by BSGI, but was detected using other nuclear medicine imaging techniques.

The study aimed to evaluate the usability of sterile bag collection (SBC) urinalysis and urine culture for diagnosing urinary tract infections (UTI). Urine culture is key for diagnosing UTI, and transurethral catheterization (TUC) or suprapubic aspiration is recommended for non-toilet-trained children. Although urine testing using SBC is non-invasive and easy, UTI can be diagnosed only if other criteria including clinical symptoms and positive urinalysis results are met. This study included 228 infants who were hospitalized for unexplained fever from October 2015 to June 2016. TUC culture, SBC urinalysis, and urine culture were performed for all patients. UTI was diagnosed when the TUC culture results met the criterion of ≥104 colony-forming units (CFU)/mL. When UTI diagnosis was made based on SBC urine colony counts ≥105 CFU/mL, the false-positive and false-negative rates were 6.3% and 70.0%, respectively. When the criterion was set as ≥104 CFU/mL, they were 23.7% and 30.0%, respectively. When both the criteria of ≥105 CFU/mL and positive urinalysis results were met, the false-positive rate was 2.4%, and the false-negative rate was 80%. Our results suggest that diagnosing UTI using SBC urinalysis and urine culture is not useful in infants with unexplained fever.

Background : Recently, ginseng (Panax ginseng C.A. Meyer.) berry has been used as a health-promoting supplements. Also, Mulberries (Morus alba L.) fruit have been used in traditional herbal medicine to treat and prevent diabetes. In this study, we measured the cytotoxicity after fermentation of the extracts in Panax Ginseng Berry and Mulberry Fruit. Methods and Results : The extracts were prepared by decoction for 3 hours in distilled water (100 g/L). The dried extract was then dissolved in phosphate-buffered saline (PBS) in preparation for use. Cell viability was examined by an MTT assay. RAW 264.7 cells were seeded at 1 × 104/mL densities in 96-well plates. Each grouping had a non-treated group as the control. The extracts were added to each well and incubated for 24 hours at 37°C and 5% CO2. The MTT solutions (5 mg/mL) were added to each well, and the cells were cultured for another 2 hours. The supernatant was then discarded, and 100 μL of dimethyl sulfoxide was added to each well. The optical density was read at 540 nm. Conclusion : Probiotics and prebiotics modulate the composition of human and domestic animal gut microbiota. The beneficial effects may result from suppression of harmful microorganisms or stimulation of organisms which contribute in a positive way to the nutrition and health of human and domestic animal. Recently, fermentation using microorganisms for the production of more effective compounds has been extensively studied. In particular, the novel pharmacological effects of a new compound generated by fermentation have been reported. Some previous studies have demonstrated that Fermented herbal medicine extract showed better bioactivity than normal herbal Plants extract when used at the same concentration.

Background : To diversify and increase the demend of Boxthorn, it is breeding for medicinal herbs, food and fresh fruit. Therefore Ningxia with the high sugar content and Black Fruit Containing a lot of functional ingredients have been used for cross breeding. As a result, many new lines were developed. Therefore It was carried out to use as a data for new varieties through the characterization of good lines. Methods and Results : 12 varieties and lines were investigated. Diploid boxthorn were Chengmyeong (Lycium chinense Mill.), Ningxia (Lycium barbarum L.) and Black Fruit (Lycium ruthenicum Murray). Tetraploid boxthorn is Whasu. Breeding Lines were CB13593-8, CB13595-4, CB13592-9, CB13596-1, CB13597-37, CB14643-43, CB14622-2 and CB14626-4. The fruit of lines crossed with Black Fruit (Lycium ruthenicum Murray) were round. The various lines were breeded with black fruit, good fruiting and good soil adaptability. Leaves were small and thin in Compared with tetraploid Boxthorn, Whasu. Sugar content was very high in CB14643-43, CB13595-4, CB13597-37 and CB13593-8. So it’s good for fresh fruit. Conclusion : CB14643-43, CB13595-4, CB13597-37 and CB13593-8 lines were good for fresh fruit because of high sugar content of the fruit. CB14622-2 and CB13596-1 lines were good for food because of fruit color, seed weight and number of seeds. But these are required function component analysis.

The optimum concentrations of clove oil as an anesthetic for olive flounder (Paralichthys olivaceus) and the stress response of the fish to clove oil anesthesia were determined over a range of water temperatures, and investigated in a simulated transport experiment using analysis of various water and physiological parameters. While the time for induction of anesthesia decreased significantly as both the concentration of clove oil and water temperature increased, the recovery time increased significantly (P<0.05). The plasma cortisol concentration in fish at each temperature increased significantly up to 12 h following exposure (P<0.05), then decreased to 48 h (P<0.05). The DO dissolved oxygen concentrations, pH values, and the fish respiratory frequencies decreased over 6 h following exposure to clove oil in all experimental groups (P<0.05), whereas the NH4 + and CO2concentrations in all experimental groups increased up to 6 h (P<0.05). The pH values and DO concentrations increased with increasing clove oil concentration (P<0.05) in the 6 h following exposure, and the CO2 and NH4 + concentrations and the respiratory frequencies decreased with increasing clove oil concentration (P<0.05). The results of this experiment suggest that clove oil reduced the metabolic activity of olive flounder, thus reducing NH4 + excretion and O2 consumption. In conclusion, clove oil appears to be a cost-effective and efficient anesthetic that is safe for use and non-toxic to the fish and users. Its use provides the potential for improved transportation of olive flounder.

Backgrounds : Pomelo (Citrus grandis Osbeck) is the kind of citrus fruit which is Dicotyledoneae belongs to Rutaceae and special product in Jeju island. According to the previous researches, coumarin, eliocitrin, naringin are identified and these kinds of constituents revealed to be effective as anticancer, antioxidant, and antidiabetic. Until recently, there are many investigations about its functional properties were reported, but investigation about biological activities depend on extraction conditions are not sufficient. Methods and Results : 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was performed by the method of Blois with minor modification. After adding DPPH radical to each sample solutions, the mixtures were incubated in 30 minutes at aphotic place. Then, the degree of scavenging activity was recorded by microplate reader at 490 nm. The scavenging activity was expressed by RC50, which is the concentration of sample solution necessitated to scavenge 50% DPPH radical against negative control. For α-glucosidase inhibitory activity, the method using p-nitrophenyl-α-D-glucopyranoside (pNPG) was applied. To each samples, α-glucosidase and pNPG were mixed and incubated, consequently, Na2CO3 was added to terminate the reaction. Finally, absorbance was read at 450 nm. The same as DPPH radical scavenging activity, the inhibition was explicitly expressed by the amount of sample solution to inhibit 50% α-glucosidase, IC50. The 80% MeOH extract demonstrated the highest radical scavenging activity with 74.32±8.45 μg/ml. α-Glucosidase inhibitory activity was carried out to evaluate the inhibitory activity of sugar digestion and absorption and 60, 80% MeOH extract exhibited 416.35±11.07 μg/ml and 336.57±2.03 μg/ml, respectively. Conclusion : The DPPH radical scavenging and α-glucosidase inhibitory activity were evaluated in this study. The highest DPPH radical scavenging activity was seen in 80% Citrus grandis Osbeck MeOH extract, following 60% MeOH extract exhibited the second highest scavenging activity. Also, 80% MeOH extract showed 336.57±2.03 μg/ml, which was the highest α-glucosidase inhibition among all extracts.

Background : This study aimed to investigate the antioxidant and anti-inflammatory activities of water chestnut (Trapa japonica Flerow) extract. Methods and Results : The antioxidant and anti-inflammatory activities of 100% methanol extract of water chestnut were investigated. The methanol extract was evaluated for its total phenolic and flavonoid content, DPPH•(1,1-diphenyl-2-picrylhydrazyl) free-radical scavenging activity,reducing power, andeffect on nitric oxide (NO) production and cell viability using real-time polymerase chain reaction (qPCR). The total phenolic content was 438.31 ㎍ allic acid equivalent (GAE)/㎎ extract and the total flavonoid content was 61.40 ㎍ quercetin equivalent (QE)/㎎ extract. In addition, results revealed the extract possessed antioxidant activity (DPPH• free-radical scavenging activity) with IC50 value of 5.28 ㎍㎖ The reducing power of the extract was assayed spectro photometrically and showed Abs of 0.71 at 100 ㎍㎖ Furthermore, extracts of water chestnut exhibited no cytotoxicity in RAW 264.7 cells. In addition, the NO assay revealed that LPS-induced NO production was significantly inhibited following treatment with water chestnut extracts. The expression of pro-inflammatory proteins such as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 decreased in a concentration-dependent manner. The water chestnut extract also decreased tumor necrosis factor α (TNF-α) release. Conclusion : Therefore, the present findings provide scientific evidence for the nutritional potential, chemical composition, and biological activities of Trapa japonica Flerow anddemonstrate its potential use as a functional food forapplication in the pharmaceutical industry

Background : Liriope platyphylla Wang et. Tang is a perennial plant and its tuberous root is used as herbal medicine. Liriope platyphylla is grown throughout a year from April to April of next year. Recently, the production was lowered because of severe drought/rainfall and injury by successive cropping. The ridge height affected the growth of shoots and roots as affected by drought or rainfall. It is necessary to establish the cultivation techniques for stable quantity per unit area and good tuber’s quality. This experiment was carried out to select a cultivar of good tuber quality and to determine the ridge height for high-yielding. Methods and Results : It were investigated the characteristics of roots and tubers depending on different ridge heights in four varieties of Liriope platyphylla Wang et. Tang. There was not significantly different in shoot growth by different ridge heights. The tubers distribution in less than 10cm soil depth at the surface was decreased about 6.6% in the 15cm ridge height compared to 5cm. So, the mean distributed position of tubers was deepened at higher ridge. The cultivars that tubers were mainly distributed in the 10cm depth from surface was Seoungsu and Cheongyang natives’s lines. The no. of tubers per a plant and the ratio of marketable tubers were increased about 13.2% and 20.1% in the 15cm ridge height compared to 5cm. Considering the tuber sizes and ratio of marketable tubers, Cheongshim and Maekmundong 1 has good quality than Seoungsu or Cheongyang natives’s lines. The tuber yield increased about 19.5% in the 15cm ridge height compared to the 5cm. So, high ridge was advantaged to increase the yield. Conclusion : From the above results, the quality and quantity of tubers of Liriope platyphylla Wang et. Tang was good in the higher ridge. We recommended Cheongshim cultivar because of the large tuber sizes and high ratio of marketable tubers.

Background : Liriope platyphylla Wang et. Tang is a species of Liliaceae and its tuber is used as medicinal herbs. This medicinal plant is mainly cultivated in Cheongyang and Buyeo of Chungcheongnam-Do and Miryang of Gyeongsangnam-Do. It is necessary to establish a cultivation techniques for stable production to solve the problems that are found on farms. These farm surveys were carried out to obtain the basic data on soil environment and cultivation conditions at main producing areas of Chungnam-Do in Liriope platyphylla Wang et. Tang. Methods and Results : The surveys were investigated from 37 farmers in Cheongyang and 32 farmers in Buyeo who cultivate Liriope platyphylla Wang et. Tang. There were slightly differences in the local characteristics between Cheongyang and Buyeo. The rate of successive cropping for more than 3 years were 19% at Cheongyang and 41% in Buyeo. The reason may be due to the a small-owned field. It has grown 28% at Cheongyang and 59% at Buyeo in paddy fields. The injury by successive cropping that farmers argued were the increasing pest/disease occurrence, degradation of tuber quality and yield reduction. Crops planted after the harvest of L. platyphylla were mostly Pepper or soybean in upland. It is necessary to reduce the injury of successive cropping. The results of 112 soil analysis data were classified by 8 soil series. There are many acidic soil, lack of organic matter, excess phosphate. However, it did not analyzed the influences on the growth and yield of the crop as affected by different soil conditions. Conclusion : From the above results, it is necessary to develop cultivation techniques on the reduction of injury of successive cropping, such as cropping system, seedling transplanting cultivation, cultivation methods for good agricultural practices(GAP) and soil improvement.

Background : Acreage of rain-shelter plastic greenhouse to prevent anthrax is being gradually increased according to growing importance of safe Boxthorn production. But When Boxthorn is grown in the hot season in rain-shelter plastic greenhouse, quantity of Boxthorn decreases. therefore the research was carried out to investigate Fertilization mode. Methods and Results : Chungwoon was very strong self-incompatibility. Chengyangjaerae, Chengyang18 and CBP11542-206 was self-compatibility. Artificial fertilization rate was slightly higher in roof and side vents than in side vents of rain-shelter plastic greenhouse in hot season. Pollen sterility due to high temperature is not critical because artificial fertilization rate was high in side vents of rain-shelter plastic greenhouse in hot season. Airborne fertilization rate was significantly lower in all varieties. Open fertilization rate was higher in roof and side vents than in side vents of rain-shelter plastic greenhouse Conclusion : Roof and side vents was good in compared to side vents in rain-shelter plastic greenhouse of Boxthorn because of high Airborne and open fertilization rate. Self-compatibility varieties were better than self-incompatibility varieties in rain- shelter plastic greenhouse because of high open fertilization rate.

이 연구는 후기 근대주의와 포스트모더니즘이 혼재되어 있는 지금의 시 대에 어떻게 기독교가 사회 전반과 성도들의 삶에 영향력을 발휘할 수 있 을까에 대한 물음으로부터 시작되었다. 필자는 세속주의, 종교 다원주의, 상대주의, 개인주의, 물질만능주의, 그리고 포스트모더니즘의 도전과 물음 앞에서 현대 기독교가 무기력한 이유들 중에 하나가 신학과 실천, 학문과 사역, 그리고 교회와 세계 사이에서 서로에 대한 깊은 이해와 대화의 부족 에 있다고 확신한다. 근대 이전의 문화와 가치와 함께 근대의 문화와 가치가 혼재 되어 있었 던 영국의 계몽주의 시기에 존 웨슬리는 자신의 신학 방법론을 통해 기독 교의 핵심 가치인 ‘성결과 행복’을 추구 했다. 그는 당시의 세속화 되어가 는 문화와 사회에 함몰되지도 않았고 또한 당시의 문화와 사회를 배척하지 도 않았다. 웨슬리의 신학 방법론은 변화하는 시기였던 그 자신의 시대의 다양한 쟁점들에 대해 적절하게 대응하기 위한 그의 노력의 결과들 중에 하나였다. 그러한 까닭에 필자는 웨슬리의 경우를 통해서 후기 근대주의와 포스트모더니즘 양측의 도전들 속에 있는 현대 기독교의 문제들에 대한 해 결책을 발견하는데 중요한 실마리를 얻을 수 있다고 확신한다.이를 위해서 본 연구는 당시 세속 사회의 문화와 가치체계를 주도했던 영국 계몽주의 사상가들의 대표자 존 로크의 인식론과 그에 대한 대응으로 서의 존 웨슬리 신학의 연구 방법론에 대해 고찰한다. 또한 이 고찰은 행 복에 대한 관점으로 인간의 삶의 궁극적 목적을 설명하고 있는 행복론 (eudemonism)적 측면에서 그들의 인식론 체계들이 궁극적으로 지향하는 행복의 본질에 대한 그들 각자의 관점의 조사도 병행한다. 여기서 특별히 필자는 존 웨슬리의 신학 방법론 속에 있는 공동체 내에서뿐만이 아니라 기독교의 타 전통 그리고 세속 사회와의 대화에 대한 개방성에 독자들이 관심을 가져 줄 것을 요청한다.

This study investigated the association between PM2.5 concentrations obtained with portable real-time monitors and those obtained with gravimetric methods in national urban air-quality monitoring sites in Seoul, South Korea. We used the SidePak AM510 Personal Aerosol Monitor (TSI Inc., 500 Cardigan Road Shoreview, MN) and DustTrak DRX 8533 (TSI Inc., 500 Cardigan Road Shoreview, MN) as portable real-time monitors for measuring PM2.5 concentrations and compared these values with those measured with the PMS-103 or SEQ 47/50 models operated by Federal Reference Method (FRM) or the European Committee for Standardization(ECS), respectively, in national urban air-quality monitoring sites in Seoul. Measurements were conducted every other day in the winter and spring seasons of 2014. The estimated daily mean concentrations of PM2.5 ranged between 13.4 and 161.9 μg/m3 using AM 510 and between 22.0 and 156.0 μg/m3 using DustTrak. The Spearman correlation coefficient for PM2.5 concentrations between AM 510 and gravimetric results was 0.99, and the correlation between DustTrak and gravimetric results was 0.87. The correction factor suggested was 0.42 and 0.29 for AM 510 and DustTrak, respectively. We found that PM2.5 concentrations measured with real-time monitors could overestimate true PM2.5 concentrations and therefore the application of a correction factor (0.43) is strongly suggested for quantification when Real-time monitors were operated of PM2.5 levels at urban atmospheric environment of South Korea.

Rectal melanoma is extremely rare. Its histologic variability and difference in immunohistochemical (IHC) expression may hinder the correct diagnosis. Seventy-three years old Korean woman complained of bloody stool and found a 2cm sized rectal pedunculated polyp on colonoscopy. There was some disparity in IHC expressions as well as cytological morphology between biopsy and surgically resected specimen. When strong immunoreactivity of S-100 is encountered in anorectal lesion with unusual morphology, multiple IHC analysis and high suspicion of anorectal melanoma could lead to correct diagnosis.

New observations for the times of minimum lights of a well-known apsidal motion star CW Cephei were made using a 0.6 m wide field telescope at Jincheon station of Chungbuk National University Observatory, Korea during the 2015 observational season. We determined new times of minimum lights from these observations and analyzed O-C diagrams together with collected times of minima to study both the apsidal motion and the Light Time Effect (LTE) suggested in the system. The new periods of the apsidal motion and the LTE were calculated as 46.6 and 39.3 years, respectively, which were similar but improved accuracy than earlier ones investigated by Han et al. (2002), Erdem et al. (2004) and Wolf et al. (2006).