Background: Static hamstring stretching exercises have been widely used to improve flexibility of the hamstring muscles. However, few studies have examined the influence of standing static hamstring stretching (e.g., jack-knife stretching) on movements of the lumbopelvic–hip complex. Objectives: To examine the short-term effects of jack-knife stretching on movements of the lumbopelvic–hip complex. Design: Case series. Methods: Fourteen participants with hamstring tightness (8 male, 6 female) were recruited. Participants performed jack-knife stretching for 150 s. Before and after stretching, participants performed the finger-to-floor distance (FFD), sit and reach (SRT), active knee extension (AKE), passive straight leg raising (PSLA), and active straight leg raising (ASLR) tests as well as pelvic tilt while standing to identify the effects of stretching. Results: There were significant improvements in the FFD, SRT, AKE, PSLA, and ASLR tests after stretching. However, pelvic tilt angle while standing did not significantly change. Conclusion: Jack-knife stretching can be a useful exercise to improve flexibility of the hamstring muscles, but not pelvic alignment while standing.

최근에 감에서 떫은맛을 조절하는 AST에 연관된 지역에서 분자 표지들이 개발되었다. 이중에서 sequence characterized amplified region (SCAR) marker는 5R region에 인접한 지역에서 개발되었다. 하지만 이 SCAR마커는 분석 방법이 다소 복잡하고 해석이 어려워 많은 교배실생을 분석할 경우에는 적합하지 않다. 우리는 5R 지역의 sequences에 기반하여 high-resolution melting (HRM)-based 분자 표지를 개발하였다. 개발된 HRM preimer set을 8개 품종의 단감 및 떫은감에 대해 적용한 결과 단감 품종에서는 직선을 나타낸 반면 떫은감 품종에서는 다양한 크기의 곡선으로 나타나서 차이를 확인할 수 있었다. 결과적으로 이번 연구에서 개발된 HRM primer set은 분자 표지를 활용한 감 품종 육성 연구에 매우 효율적으 로 활용될 수 있을 것으로 기대된다.

This study examines whether the lexical pitch accent of the Kyungsang dialect and /wɑ/ monophthongization are imitated by Seoul dialect speakers in an auditory naming task. The goal of the study relates to what is imitated in the phonetic signal. To answer this question, the study examines how relative salience between two linguistic features affects phonetic accommodation. Fifty words as produced by a speaker of the Kyungsang dialect served as stimuli for a shadowing task. The first and second formants of disyllabic words containing the diphthong /wɑ/ and the F0 of disyllabic words with the HL tone were acoustically analyzed for phonetic accommodation. Overall, the results suggest that in terms of the diphthong /wɑ/, participants were more likely to converge toward the Kyungsang model talker, producing their vowel as more monothongized. With respect to the lexical pitch accent, participants were less likely to converge to the model talker, producing the target words with the same tone.

비고츠스키(Vygosky)의 사회문화 이론은 특히 제2외국어 학습에 있어서 중요한 의미를 갖는다. 학생들은 협동적인 학습 활동을 하면서 영어를 더 잘 배우고 성장하며 발전한다. 게다가 쓰기단계는 사회적 상호작용을 통해 복잡한 인식과정을 거쳐 향상되고 발전한다. 본 논문은 쓰기 수업을 하는 학생들로부터 피드백을 도출하기 위해 구글 독스(Google Docs)를 이용하여 사회문화이론이 쓰기수업에 어떻게 적용되었는지를 설명하고자 한다. 본 연구는 한국 모 대학의 영어수업에서 진행되었고, 참가자는 영어교육과 학생 11명이다. 연구자는 반성적 실천(Reflective Practice), 비계설정(Scaffolding), 동료 피드백 촉진(Peer Feedback Facilitation) 등의 과정을 통해 강사가 학생들이 한 문장에서 시작하여 단락까지 씀으로써 결국은 영어로 에세이를 쓸 수 있게 효과적으로 준비할 수 있었다. 이 연구에서 다섯 단락 정도의 에세이를 쓸 수 있을 만큼 학생들의 작문실 력은 향상되었고, 격려를 통해 서로 성장하고 발전할 수 있었다. 또한 이 과정에서 학생들의 사회적 기술과 공감능력이 향상되었고 수업 분위기도 개선되었다. 이러한 기술적인 동료 피드백은 동기부여를 위한 효율적인 방식이며, 학생들에게는 영어쓰기학습에서 자신감을 주는 것으로 나타난다. 사회문화이론의 적용을 통해 학생들은 제2외국어에 대한 지식을 습득 하고 더 발전시킬 수 있으며, 낮은 단계의 이해에서 더 높은 수준의 지식 으로 나아가게 하는 상호작용의 시너지를 만들어 낸다.

감성지능(EQ)은 현대 심리학에서 매우 중요한 주제이다. 전문 분야와 학교에서 이루어진 기존 연구들은 모든 사람을 대상으로 하면서 학교생활에서 학생들의 전반적인 성공을 다루고 있다. 최근 직장과 대학 캠퍼스의 감성지능에 관한 여러 연구들은 감성지능이 한국 교육 연구에 있어 그만큼 중요한 관심사가 되고 있음을 입증한다. 본 연구는 한국에서의 교육 연구와 감성지능에 대한 새로운 통찰을 마련하기 위해 한국 대학교에서 100여명 대학생을 상대로 설문조사 및 데이터분석을 통해 연구하였다. 연구결과로 첫째, 남학생의 감성지능이 여학생보다 더 높았고, 둘째, 다른 초등 및 중학생을 대상으로 한 테스트와 비교해 볼 때, 101명의 대학생 1학년의 감성지능이 초등학생과 매우 유사한 수준으로 나타났다. 그러나 정서조절능력에서는 대학생 1학년이 더 높게 나타난 반면, 정서표현 측면에서는 더 낮은 수준을 보여주었다. 본 연구의 결론은 학생들을 격려, 지지하면서 그들의 긍정적이고 의미있는 경험을 할 수 있도록 하고 정서적 학습을 향상시키는 교육적 실천의 필요성을 보여 줌으로써 한국의 교육 현장에 중요한 영향을 끼친다.

There have been a lot of studies in the past for the method of predicting the failure of a machine, and recently, a lot of researches and applications have been generated to diagnose the physical condition of the machine and the parts and to calculate the remaining life through various methods. Survival models are also used to predict plant failures based on past anomaly cycles. In particular, special machine that reflect the fluid flow and process characteristics of chemical plants are connected to hundreds or thousands of sensors, so there are not many factors that need to be considered, such as process and material data as well as application of derivative variables. In this paper, the data were preprocessed through time series anomaly detection based on unsupervised learning to predict the abnormalities of these special machine. Next, clustering results reflecting clustering-based data characteristics were applied to produce additional variables, and a learning data set was created based on the history of past facility abnormalities. Finally, the prediction methodology based on the supervised learning algorithm was applied, and the model update was confirmed to improve the accuracy of the prediction of facility failure. Through this, it is expected to improve the efficiency of facility operation by flexibly replacing the maintenance time and parts supply and demand by predicting abnormalities of machine and extracting key factors.

The purpose of this study was to examine the characteristics of acetaminophen (APAP)-induced liver damage, using fluorescence bioimaging, serum biochemistry, and histopathology. At six weeks of age, eighteen mice were divided into three groups as group 1 (G1) as control, group 2 (G2) as fluorescence probe control and group 3 (G3) as APAP-treated. G3 mice were orally treated with APAP (800 mg/kg b.w.), while G1 and G2 mice were treated with 0.9% saline. Twenty-two hours after APAP treatment, G2 and G3 mice were intravenously treated with Annexin-Vivo 750 as probe, while G1 mice were treated with saline. Fluorescence bioimaging was performed at two hours after probe treatment. The mice were sacrificed and serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase were analyzed. Liver damage was examined by hematoxylin and eosin (H&E) staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. In vivo bioimaging, fluorescence intensity of the region of interest (ROI) was significantly increased in the livers of G2 and G3 mice compared with those in G1 mice (p<0.05 and p<0.01). In addition, ex vivo bioimaging confirmed that the fluorescence intensity of the ROI was significantly increased in the livers of G2 and G3 mice compared with those in G1 mice (p<0.05 and p<0.01). All examined serum parameters of G3 were significantly increased compared with G1 and G2 (p<0.05 and p<0.01). H&E examination showed acute hepatic cell necrosis in the livers of G3 mice, while there was no cell death in the livers of G1 and G2 mice. TUNEL staining also showed many cell death features in G3 mice, whereas no pathological findings were shown in G1 or G2 mice. In summary, fluorescence bioimaging showed the possibility of cell death detection in the livers of mice treated with APAP, and this was corroborated by serum chemistry and histopathological examination.

Background: Lower trapezius muscle function is important for the prevention and treatment of shoulder injuries. However, scapular posterior tilt movement has been overlooked in lower trapezius strengthening exercise programs. Objective: To examine the effects of prone arm lifting with scapular posterior tilt (PALSPT) on trapezius muscles. Design: Crossover study Methods: 17 healthy males were recruited for participation in this study. Participants performed backward rocking diagonal arm lifting (BRDAL) and PALSPT. To train participants in scapular posterior tilt movements for PALSPT, visual biofeedback of scapular movements was provided using a motion sensor. Electromyography (EMG) activities of the middle and lower trapezius were recorded using a surface EMG system. Differences in middle and lower trapezius muscle activity between BRDAL and PALSPT exercises were analyzed. Results: Lower trapezius muscle activity was significantly greater during PALSPT than during BRDAL (p=.006). Although greater EMG activity was observed in the middle trapezius during PALSPT than during BRDAL, this difference was not significant (p=.055). Conclusions: The results of the present study indicate that scapular posterior tilt movements must be considered in lower trapezius muscle strengthening programs.

Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging.

Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) are major periodontal pathogens. Lipopolysaccharides (LPSs) from periodontal bacteria play an important role in periodontal pathogenesis by stimulating host cells to produce inflammatory cytokines. In this study, highly pure LPSs from the five major periodontopathogens were prepared, and their monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α)-inducing activities were compared in human umbilical vein endothelial cells (HUVECs) and THP-1 macrophagic cells, respectively. In HUVECs, LPSs from Aa and Fn were potent stimulators for MCP-1 induction; however, LPSs from Pg, Pi, and Tf were much weaker MCP-1 inducers. In THP-1 cells, LPSs from Pg, Aa, and Fn were relatively strong inducers of TNF-α, whereas LPSs from Pi and Tf produced little activity. The Toll-like receptor (TLR)2/TLR4 dependency of various LPSs was also determined by measuring NF-κB reporter activity in TLR2- or TLR4-expressing 293 cells. LPSs from Aa, Fn, and Tf stimulated only TLR4; however, LPSs from Pg and Pi stimulated both TLR2 and TLR4. These results suggest that LPSs from major periodontal bacteria differ considerably in their cell-stimulating activity.

The oral care probiotic strain Weissella cibaria CMU (oraCMU) inhibits volatile sulphur compounds associated with halitosis, presumably by inhibiting the growth of associated oral pathogens. In the present study, we investigated whether oraCMU inhibits the production of these compounds by suppressing the expression of mgl . This gene encodes L-methionine-α-deamino-γ-mercaptomethane-lyase (METase) and is involved in the production of methyl mercaptan (CH3SH) by Porphyromonas gingivalis . Therefore, we specifically investigated the effects of oraCMU on the growth, CH3SH production, METase activity, and mgl expression of P. gingivalis . The minimum inhibitory concentrations of cell-free supernatant and secreted proteins from oraCMU were 125 mg/mL and 800 µg/mL, respectively. At sub-minimum inhibitory concentration levels, these metabolites inhibited CH3SH production, but they also reduced P. gingivalis viability. Only heat-killed oraCMU decreased CH3SH production without affecting P. gingivalis viability. Heat-killed oraCMU also inhibited METase activity toward L-methionine and mgl mRNA expression (p < 0.05). In summary, we demonstrated the inhibition of volatile sulphur compounds via the antimicrobial action of oraCMU and, for the first time, the inhibition of such compounds by heat-killed oraCMU, which occurred at the molecular level.

This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histopathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2 in the CND group vs. 3.3 ± 0.34 mm2 in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2 in the CND group vs. 2.0 ± 0.33 mm2 in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.

In this study, steric height variability in the East Asian Seas (EAS) has been analyzed by using ocean reanalysis intercomparison project (ORA-IP) data. Results show that there are significant correlations between ocean reanalysis and satellite data except the phase of annual cycle and interannual signals of the Yellow Sea. Reanalysis ensemble derived from 15-different assimilation systems depicts higher correlation (0.706) than objective analysis ensemble (0.296) in the EAS. This correlation coefficient is also much higher than that of the global ocean (0.441). For the longterm variability of the thermosteric sea level during 1993-2010, a significant warming trend is found in the East/Japan Sea, while cooling trend is shown around the Kuroshio extension area. For the halosteric sea level, a dominant freshening trend is found in the EAS. However, below 300 m depth around this area, the signal-to-noise ratio of the linear trend is generally less than one, which is related to the low density of observation data.