순간증모제는 산화철, 이산화 타이타늄 등의 다양한 금속을 함유하고 있으며 이들은 대체로 금속 인공물을 발생시키 는 원인이 된다. 본원에서 발생한 순간증모제에 의한 자화율 인공물 사례를 공유함으로써 뇌 자기공명영상 검사 전 순간증모제의 사용 여부 확인 및 제거의 필요성을 강조하고자 하였다. 본원의 사례에서 주 자장 세기에 따라 3.0T에 서 검사한 영상에 비해 1.5T에서 검사한 영상에서 자화율 인공물의 강도가 적음을 확인하였다. 시퀀스에 따라서 스핀 에코 기법 영상보다 경사 에코 시퀀스와 EPI에서 큰 자화율 인공물을 발견할 수 있었다. 또한, 순간증모제는 인공물의 원인이 될 뿐만 아니라 영상의 진단적 가치에 영향을 미쳐 뇌 질환을 진단하는데 오진을 초래할 가능성이 있음을 확인하였다. 따라서 자화율 인공물의 발생을 감소시키기 위해서 뇌 자기공명영상 검사 전 순간증모제 사용 여부를 확인하고 되도록 제거한 후 검사를 시행할 것을 권고한다.

본 연구는 코마개의 사용 여부에 따라 MRI 영상을 분석함으로써 숨 참기의 정확도를 향상할 도구로써 코마개가 실 효성이 있는지 검증하고자 하였다. 이를 위해 수검자에게 코마개가 없는 자연 호흡과 코마개를 사용한 구강 호흡 상태에서 호기 후 숨 참기를 지시하고 MRI 영상을 획득하였다. 영상은 2D 경사 자기장 에코 시퀀스로 획득하였고 초당 1장씩, 총 15장을 얻어 숨 참기 상태를 분석하였다. 숨 참기의 상태를 정량적으로 평가하기 위해 우측 폐 면적 을 측정하였다. 그리고 첫 번째 영상의 폐 면적을 기준으로 나머지 영상들에서 폐 면적의 절대 오차값을 구해 비교하 였다. 더불어 첫 번째 영상을 기준으로 나머지 영상들의 기하학적 유사도를 평가하기 위해 SSIM 값을 계산하였다. 실험 결과, 자연 호흡 상태에서 절대 오차는 평균 216.79 ㎟로 나타났다. 반면, 코마개를 사용한 구강 호흡의 경우 평균 55.94 ㎟로 나타나 자연 호흡과 비교하여 약 74.19% 감소하였다. SSIM 값은 자연 호흡 시 평균 0.7, 구강 호흡 시 0.76으로 나타나 기하학적 유사도가 약 6% 향상되었다. 이는 코마개 사용 시 호흡의 초기 상태를 잘 유지함 으로써 숨 참기의 정확도가 향상되어 능동적으로 호흡 상태를 조절할 수 있는 도구로써 충분한 가치가 있음을 증명한 다. 따라서 복부 MRI 검사에서 호흡에 따른 인공물을 개선하는 데 코마개가 도움을 줄 수 있으며 영상 개선 및 업무 효율을 높이는 도구로써 충분히 활용할 수 있다.

Headwater streams provide various microhabitats, resulting in high diversity of macroinvertebrate community. In this study, we compared the differences of communities between two adjacent headwater streams (Jangjeon stream (GRJ; GRJ1-GRJ5) and Haanmi stream (GRH; GRH1-GRH3)) in Jungwang and Gariwang mountains, Gangwon-do and evaluated the effects of habitat condition to the macroinvertebrates community composition. In order to characterize the macroinvertebrate communities and extract influential environmental factors, we applied to Cluster analysis (CA), Indicator species analysis and Non-metric multidimensional scaling (NMDS). Total 33,613 individuals in 3 phyla, 5 classes, 13 orders, 51 families, and 114 taxa (genera or species) were collected. Gammarus sp. was dominant at the upper stream of GRJ, whereas Chironomidae spp. was abundant at GRH and the downstream of GRJ. The CA classified samples into six clusters (1-6) reflecting spatial and temporal variation of benthic macroinvertebrate communities. Benthic macroinvertebrate community composition was significantly different between two adjacent streams. Sweltsa sp. 1, Psilotreta kisoensis, Rhyacophila shikotsuensis and Serratella setigera were identified as representative indicator species for clusters 1, 2, 3 and 5, respectively. Similar to CA results, NMDS revealed the spatial and temporal differences of benthic macroinvertebrate communities, indicating the difference of community composition as well as microhabitat condition. Forest composition, proportion of boulders (>256 mm), and water velocity were main factors affecting the macroinvertebrate community composition.

Although Semisulcospira libertina is generally regarded as a supplement for the alleviation of alcohol hangover, little is known about its effects on cell metabolism. Therefore, this study was conducted to analyze the constituents of the extracts prepared using different extraction methods and to compare their biochemical properties. The amino acid contents were found to be much higher in acidic and enzymatic hydrolysates than hot water extracts from S. libertina. DPPH radical scavenging activities in acidic and enzymatic hydrolysates were higher than those of hot water extracts. Three types of S. libertina hydrolysate was added to HepG2 cells damaged by acetaminophen (AAP), after which the survival rate of HepG2 cell were measured. In addition, lactate dehydrogenase (LDH) activities in the culture media were evaluated. The survival rates of HepG2 cells were 77.0±4.3% and 81.5±1.3% at 3 h and 5h enzymatic hydrolysates, respectively. These cell survival rates were higher compared to those of the negative control group (67.8±4.3%) treated only with acetaminophen. Cellular toxicities induced by treatment with AAP were also significantly alleviated in response to treatment with the extracts of S. libertina. In addition, the activities of 2 key enzymes that metabolize ethanol, alcohol dehydrogenase and aldehyde dehydrogenase, were upregulated by 4.7- and 2.7-fold respectively in response to treatment with a 3 h enzymatic hydrolysate of S. libertina. Taken together, these results provide biochemical evidence of the method by which S. libertina exerts its biological functions, including the alleviation of alcohol hangover and the protection of liver cells against toxic insults.

Although Semisulcospira libertina is generally regarded as a supplement for the alleviation of alcohol hangover, little is known about its effects on cell metabolism. Therefore, this study was conducted to analyze the constituents of the extracts prepared using different extraction methods and to compare their biochemical properties. The amino acid contents were found to be much higher in acidic and enzymatic hydrolysates than hot water extracts from S. libertina. DPPH radical scavenging activities in acidic and enzymatic hydrolysates were higher than those of hot water extracts. Three types of S. libertina hydrolysate was added to HepG2 cells damaged by acetaminophen (AAP), after which the survival rate of HepG2 cell were measured. In addition, lactate dehydrogenase (LDH) activities in the culture media were evaluated. The survival rates of HepG2 cells were 77.0±4.3% and 81.5±1.3% at 3 h and 5h enzymatic hydrolysates, respectively. These cell survival rates were higher compared to those of the negative control group (67.8±4.3%) treated only with acetaminophen. Cellular toxicities induced by treatment with AAP were also significantly alleviated in response to treatment with the extracts of S. libertina. In addition, the activities of 2 key enzymes that metabolize ethanol, alcohol dehydrogenase and aldehyde dehydrogenase, were upregulated by 4.7- and 2.7-fold respectively in response to treatment with a 3 h enzymatic hydrolysate of S. libertina. Taken together, these results provide biochemical evidence of the method by which S. libertina exerts its biological functions, including the alleviation of alcohol hangover and the protection of liver cells against toxic insults.